OBJECTIVE: To examine associations between early-life sun exposure and risk of invasive cutaneous melanoma diagnosed between ages 18 and 39 years. METHODS: Data were analysed from 606 cases and 481 controls from the Australian Melanoma Family Study, a population-based, case-control-family study. Self- and parent-reported sun exposure was collected by interview. Odds ratios (OR) were estimated using unconditional logistic regression, adjusted for potential confounders. RESULTS: Self-reported childhood total sun exposure was not associated with melanoma overall, but was positively associated with melanoma diagnosed at 18-29 years of age (OR for highest vs. lowest quartile: 3.21, 95% confidence intervals (CI) 1.38-7.44; P (trend) 0.02; P (interaction) by age group 0.09). Analyses restricted to participants whose self-reported sun exposure was concordant with that recalled by their parents gave an OR for the highest versus lowest tertile of childhood total sun exposure of 2.28 (95% CI 1.03-5.04; P (trend) 0.05), and for any versus no severe childhood sunburn of 2.36 (95% CI 1.05-5.31). The association of self-reported severe sunburn with melanoma was evident only in people who tended to tan rather than burn and in people who had few nevi. CONCLUSION: The association of early-life sun exposure with early-onset melanoma is influenced by host factors.
OBJECTIVE: To examine associations between early-life sun exposure and risk of invasive cutaneous melanoma diagnosed between ages 18 and 39 years. METHODS: Data were analysed from 606 cases and 481 controls from the Australian Melanoma Family Study, a population-based, case-control-family study. Self- and parent-reported sun exposure was collected by interview. Odds ratios (OR) were estimated using unconditional logistic regression, adjusted for potential confounders. RESULTS: Self-reported childhood total sun exposure was not associated with melanoma overall, but was positively associated with melanoma diagnosed at 18-29 years of age (OR for highest vs. lowest quartile: 3.21, 95% confidence intervals (CI) 1.38-7.44; P (trend) 0.02; P (interaction) by age group 0.09). Analyses restricted to participants whose self-reported sun exposure was concordant with that recalled by their parents gave an OR for the highest versus lowest tertile of childhood total sun exposure of 2.28 (95% CI 1.03-5.04; P (trend) 0.05), and for any versus no severe childhood sunburn of 2.36 (95% CI 1.05-5.31). The association of self-reported severe sunburn with melanoma was evident only in people who tended to tan rather than burn and in people who had few nevi. CONCLUSION: The association of early-life sun exposure with early-onset melanoma is influenced by host factors.
Authors: Wei-Yin Lim; Rachael L Morton; Robin M Turner; Marisa C Jenkins; Pascale Guitera; Les Irwig; Angela C Webster; Mbathio Dieng; Robyn P M Saw; Donald Low; Cynthia Low; Katy J L Bell Journal: JAMA Dermatol Date: 2018-04-01 Impact factor: 10.282
Authors: Caroline G Watts; Martin Drummond; Chris Goumas; Helen Schmid; Bruce K Armstrong; Joanne F Aitken; Mark A Jenkins; Graham G Giles; John L Hopper; Graham J Mann; Anne E Cust Journal: JAMA Dermatol Date: 2018-09-01 Impact factor: 10.282
Authors: Katherine Y Wojcik; Loraine A Escobedo; Ashley Wysong; Julia E Heck; Beate Ritz; Ann S Hamilton; Joel Milam; Myles G Cockburn Journal: Epidemiology Date: 2019-03 Impact factor: 4.860
Authors: Anne E Cust; Chris Goumas; Kylie Vuong; John R Davies; Jennifer H Barrett; Elizabeth A Holland; Helen Schmid; Chantelle Agha-Hamilton; Bruce K Armstrong; Richard F Kefford; Joanne F Aitken; Graham G Giles; D Bishop; Julia A Newton-Bishop; John L Hopper; Graham J Mann; Mark A Jenkins Journal: BMC Cancer Date: 2013-09-04 Impact factor: 4.430