Literature DB >> 21468229

The core human mitochondrial transcription initiation complex: It only takes two to tango.

Timothy E Shutt1, Megan Bestwick, Gerald S Shadel.   

Abstract

We recently demonstrated that the core transcription initiation complex in human mitochondria is a two-component system (POLRMT and h-mtTFB2). Human mtTFA/TFAM, previously proposed to be a requisite initiation complex member, is dispensable for promoter-specific initiation in vitro. We propose that it instead regulates relative promoter activity and/or overall nucleoid transcription and replication potential.

Entities:  

Year:  2011        PMID： 21468229      PMCID： PMC3062394          DOI： 10.4161/trns.2.2.14296

Source DB:  PubMed          Journal:  Transcription        ISSN： 2154-1272


  30 in total

1.  Similarity of human mitochondrial transcription factor 1 to high mobility group proteins.

Authors:  M A Parisi; D A Clayton
Journal:  Science       Date:  1991-05-17       Impact factor: 47.728

Review 2.  Initiation and beyond: multiple functions of the human mitochondrial transcription machinery.

Authors:  Nicholas D Bonawitz; David A Clayton; Gerald S Shadel
Journal:  Mol Cell       Date:  2006-12-28       Impact factor: 17.970

3.  The mitochondrial DNA genetic bottleneck results from replication of a subpopulation of genomes.

Authors:  Timothy Wai; Daniella Teoli; Eric A Shoubridge
Journal:  Nat Genet       Date:  2008-12       Impact factor: 38.330

4.  Elucidation of separate, but collaborative functions of the rRNA methyltransferase-related human mitochondrial transcription factors B1 and B2 in mitochondrial biogenesis reveals new insight into maternally inherited deafness.

Authors:  Justin Cotney; Sharen E McKay; Gerald S Shadel
Journal:  Hum Mol Genet       Date:  2009-05-05       Impact factor: 6.150

5.  Composition and dynamics of human mitochondrial nucleoids.

Authors:  Nuria Garrido; Lorena Griparic; Eija Jokitalo; Jorma Wartiovaara; Alexander M van der Bliek; Johannes N Spelbrink
Journal:  Mol Biol Cell       Date:  2003-04       Impact factor: 4.138

Review 6.  Mitochondrial transcription initiation. Variation and conservation.

Authors:  G S Shadel; D A Clayton
Journal:  J Biol Chem       Date:  1993-08-05       Impact factor: 5.157

7.  Evidence for an early gene duplication event in the evolution of the mitochondrial transcription factor B family and maintenance of rRNA methyltransferase activity in human mtTFB1 and mtTFB2.

Authors:  Justin Cotney; Gerald S Shadel
Journal:  J Mol Evol       Date:  2006-10-06       Impact factor: 2.395

8.  Drosophila mitochondrial transcription factor A (d-TFAM) is dispensable for the transcription of mitochondrial DNA in Kc167 cells.

Authors:  A Goto; Y Matsushima; T Kadowaki; Y Kitagawa
Journal:  Biochem J       Date:  2001-03-01       Impact factor: 3.857

9.  Methylation of 12S rRNA is necessary for in vivo stability of the small subunit of the mammalian mitochondrial ribosome.

Authors:  Metodi D Metodiev; Nicole Lesko; Chan Bae Park; Yolanda Cámara; Yonghong Shi; Rolf Wibom; Kjell Hultenby; Claes M Gustafsson; Nils-Göran Larsson
Journal:  Cell Metab       Date:  2009-04       Impact factor: 27.287

10.  Organization and dynamics of human mitochondrial DNA.

Authors:  Frédéric Legros; Florence Malka; Paule Frachon; Anne Lombès; Manuel Rojo
Journal:  J Cell Sci       Date:  2004-05-11       Impact factor: 5.285
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  22 in total

1.  Transcriptional requirements of the distal heavy-strand promoter of mtDNA.

Authors:  Ornella Zollo; Valeria Tiranti; Neal Sondheimer
Journal:  Proc Natl Acad Sci U S A       Date:  2012-03-27       Impact factor: 11.205

2.  The C-terminal tails of the mitochondrial transcription factors Mtf1 and TFB2M are part of an autoinhibitory mechanism that regulates DNA binding.

Authors:  Urmimala Basu; Nandini Mishra; Mohammed Farooqui; Jiayu Shen; Laura C Johnson; Smita S Patel
Journal:  J Biol Chem       Date:  2020-04-02       Impact factor: 5.157

Review 3.  Mitochondrial transcription: lessons from mouse models.

Authors:  Susana Peralta; Xiao Wang; Carlos T Moraes
Journal:  Biochim Biophys Acta       Date:  2011-11-18

4.  Mitochondrial genome-maintaining activity of mouse mitochondrial transcription factor A and its transcript isoform in Saccharomyces cerevisiae.

Authors:  Young Geol Yoon; Michael D Koob; Young Hyun Yoo
Journal:  Gene       Date:  2011-06-12       Impact factor: 3.688

5.  Human mitochondrial transcription factors TFAM and TFB2M work synergistically in promoter melting during transcription initiation.

Authors:  Aparna Ramachandran; Urmimala Basu; Shemaila Sultana; Divya Nandakumar; Smita S Patel
Journal:  Nucleic Acids Res       Date:  2016-11-29       Impact factor: 16.971

Review 6.  Mechanisms of mammalian mitochondrial transcription.

Authors:  Emilie Bouda; Anthony Stapon; Miguel Garcia-Diaz
Journal:  Protein Sci       Date:  2019-07-31       Impact factor: 6.725

Review 7.  Matrix proteases in mitochondrial DNA function.

Authors:  Yuichi Matsushima; Laurie S Kaguni
Journal:  Biochim Biophys Acta       Date:  2011-12-08

Review 8.  Mechanism of transcription initiation by the yeast mitochondrial RNA polymerase.

Authors:  Aishwarya P Deshpande; Smita S Patel
Journal:  Biochim Biophys Acta       Date:  2012-02-14

Review 9.  The mitochondrial nucleoid: integrating mitochondrial DNA into cellular homeostasis.

Authors:  Robert Gilkerson; Liliana Bravo; Iraselia Garcia; Norma Gaytan; Alan Herrera; Alicia Maldonado; Brandi Quintanilla
Journal:  Cold Spring Harb Perspect Biol       Date:  2013-05-01       Impact factor: 10.005

Review 10.  Accessorizing the human mitochondrial transcription machinery.

Authors:  Megan L Bestwick; Gerald S Shadel
Journal:  Trends Biochem Sci       Date:  2013-04-27       Impact factor: 13.807
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