OBJECTIVE: Diabetic ketoacidosis (DKA) remains a major cause of hospitalization and death in children and adolescents with established type 1 diabetes despite DKA preventing strategies. The aim of the study was to determine incidence and risk factors for DKA in a large cohort of young diabetic patients. METHODS: This investigation uses the dpv-wiss base containing data on 28 770 patients with type 1 diabetes <20yr, from Germany and Austria. For each patient the most recent year of follow-up was evaluated. DKA was defined as pH < 7.3 and/or hospital admission as a result of DKA, excluding onset DKA. RESULTS: Mean age of the study cohort was 13.96 ± 4.0 yr (47.9% females). A total of 94.1% presented with no episode, 4.9% with 1 episode, and 1.0% with recurrent DKA (≥2). When comparing these three groups, age (p < 0.01), HbA1c (p < 0.01), and insulin dose (p < 0.01) were significantly higher in patients with recurre nt DKA. Incidence of DKA was significantly higher in females (7.3 ± 0.5 vs. 5.8 ± 0.2; p = 0.03) and in patients with migration background (7.8 ± 0.6 vs. 6.3 ± 0.3; p = 0.02). No significant association was found with treatment type and diabetes duration. CONCLUSION: In a cohort of European paediatric diabetic patients, the rate of DKA was significantly higher in females and in children with migration background and early teenage years.
OBJECTIVE:Diabetic ketoacidosis (DKA) remains a major cause of hospitalization and death in children and adolescents with established type 1 diabetes despite DKA preventing strategies. The aim of the study was to determine incidence and risk factors for DKA in a large cohort of young diabeticpatients. METHODS: This investigation uses the dpv-wiss base containing data on 28 770 patients with type 1 diabetes <20yr, from Germany and Austria. For each patient the most recent year of follow-up was evaluated. DKA was defined as pH < 7.3 and/or hospital admission as a result of DKA, excluding onset DKA. RESULTS: Mean age of the study cohort was 13.96 ± 4.0 yr (47.9% females). A total of 94.1% presented with no episode, 4.9% with 1 episode, and 1.0% with recurrent DKA (≥2). When comparing these three groups, age (p < 0.01), HbA1c (p < 0.01), and insulin dose (p < 0.01) were significantly higher in patients with recurre nt DKA. Incidence of DKA was significantly higher in females (7.3 ± 0.5 vs. 5.8 ± 0.2; p = 0.03) and in patients with migration background (7.8 ± 0.6 vs. 6.3 ± 0.3; p = 0.02). No significant association was found with treatment type and diabetes duration. CONCLUSION: In a cohort of European paediatric diabeticpatients, the rate of DKA was significantly higher in females and in children with migration background and early teenage years.
Authors: David D Schwartz; Rosa Banuelos; Serife Uysal; Mili Vakharia; Kristen R Hendrix; Kelly Fegan-Bohm; Sarah K Lyons; Rona Sonabend; Sheila K Gunn; Selorm Dei-Tutu Journal: Clin Diabetes Date: 2022-04-15
Authors: Eda Cengiz; Dongyuan Xing; Jenise C Wong; Joseph I Wolfsdorf; Morey W Haymond; Arleta Rewers; Satya Shanmugham; William V Tamborlane; Steven M Willi; Diane L Seiple; Kellee M Miller; Stephanie N DuBose; Roy W Beck Journal: Pediatr Diabetes Date: 2013-03-08 Impact factor: 4.866
Authors: Mustafa Tosur; Mario A Cleves; Jay M Sosenko; Ingrid Libman; David A Baidal; Ashok Balasubramanyam; Maria J Redondo Journal: J Clin Endocrinol Metab Date: 2020-12-01 Impact factor: 5.958
Authors: Wojciech Fendler; Anna Iza Baranowska; Beata Mianowska; Agnieszka Szadkowska; Wojciech Mlynarski Journal: Acta Diabetol Date: 2011-10-01 Impact factor: 4.280