Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Antiepileptic drugs and neurodevelopment: an update.

Literature DB >> 21465150

Antiepileptic drugs and neurodevelopment: an update.

Abstract

In utero exposure to some antiepileptic drugs (AEDs) is associated with an increased risk of impaired cognitive development. Specifically, valproate and polytherapy exposure are each associated with an increased risk of cognitive impairment in children compared with other antiepileptic medications. The data regarding the risk to neurocognitive development imposed by maternal use of other AEDs are conflicting or insufficient at this time to draw definitive conclusions. Behavioral dysfunction including autistic spectrum disorder is also associated with maternal use of AEDs during pregnancy. Whether treatment with AEDs during childhood permanently affects cognitive neurodevelopment is yet to be determined.

Entities: Chemical Disease Species

Mesh：

Substances：
Anticonvulsants

Year: 2011 PMID： 21465150 PMCID： PMC6339508 DOI： 10.1007/s11910-011-0194-y

Source DB: PubMed Journal: Curr Neurol Neurosci Rep ISSN： 1528-4042 Impact factor: 5.081

46 in total

1. Changing specificity of neurotransmitter regulation of rapid dendritic remodeling during synaptogenesis.

Authors: W T Wong; R O Wong
Journal: Nat Neurosci Date: 2001-04 Impact factor: 24.884

2. Long-term neuropsychological consequences of maternal epilepsy and anticonvulsant treatment during pregnancy for school-age children and adolescents.

Authors: S Koch; K Titze; R B Zimmermann; M Schröder; U Lehmkuhl; H Rauh
Journal: Epilepsia Date: 1999-09 Impact factor: 5.864

3. Long term health and neurodevelopment in children exposed to antiepileptic drugs before birth.

Authors: J C S Dean; H Hailey; S J Moore; D J Lloyd; P D Turnpenny; J Little
Journal: J Med Genet Date: 2002-04 Impact factor: 6.318

4. Late cognitive effects of early treatment with phenobarbital.

Authors: S Sulzbacher; J R Farwell; N Temkin; A S Lu; D G Hirtz
Journal: Clin Pediatr (Phila) Date: 1999-07 Impact factor: 1.168

5. The impact of childhood epilepsy on neurocognitive and behavioral performance: a prospective longitudinal study.

Authors: L L Bailet; W R Turk
Journal: Epilepsia Date: 2000-04 Impact factor: 5.864

6. In utero exposure to phenobarbital and intelligence deficits in adult men.

Authors: J M Reinisch; S A Sanders; E L Mortensen; D B Rubin
Journal: JAMA Date: 1995-11-15 Impact factor: 56.272

7. The behavioral consequences of exposure to antiepileptic drugs in utero.

Authors: J Vinten; R L Bromley; J Taylor; N Adab; U Kini; G A Baker
Journal: Epilepsy Behav Date: 2008-12-02 Impact factor: 2.937

Review 8. Pregnancy outcomes in women with epilepsy: a systematic review and meta-analysis of published pregnancy registries and cohorts.

Authors: Kimford Meador; Matthew W Reynolds; Sheila Crean; Kyle Fahrbach; Corey Probst
Journal: Epilepsy Res Date: 2008-06-18 Impact factor: 3.045

9. Neurocognitive effects of adjunctive levetiracetam in children with partial-onset seizures: a randomized, double-blind, placebo-controlled, noninferiority trial.

Authors: Paul M Levisohn; Mark Mintz; Scott J Hunter; Haichen Yang; John Jones
Journal: Epilepsia Date: 2009-08-21 Impact factor: 5.864

10. Antiepileptic drug-induced neuronal cell death in the immature brain: effects of carbamazepine, topiramate, and levetiracetam as monotherapy versus polytherapy.

Authors: Jinsook Kim; Alexei Kondratyev; Karen Gale
Journal: J Pharmacol Exp Ther Date: 2007-07-16 Impact factor: 4.030

7 in total

Antiepileptic drugs and neurodevelopment: an update.

1. Changing specificity of neurotransmitter regulation of rapid dendritic remodeling during synaptogenesis.

2. Long-term neuropsychological consequences of maternal epilepsy and anticonvulsant treatment during pregnancy for school-age children and adolescents.

3. Long term health and neurodevelopment in children exposed to antiepileptic drugs before birth.

4. Late cognitive effects of early treatment with phenobarbital.

5. The impact of childhood epilepsy on neurocognitive and behavioral performance: a prospective longitudinal study.

6. In utero exposure to phenobarbital and intelligence deficits in adult men.

7. The behavioral consequences of exposure to antiepileptic drugs in utero.

Review 8. Pregnancy outcomes in women with epilepsy: a systematic review and meta-analysis of published pregnancy registries and cohorts.

9. Neurocognitive effects of adjunctive levetiracetam in children with partial-onset seizures: a randomized, double-blind, placebo-controlled, noninferiority trial.

10. Antiepileptic drug-induced neuronal cell death in the immature brain: effects of carbamazepine, topiramate, and levetiracetam as monotherapy versus polytherapy.

1. Psychosocial Profile and Quality of Life in Children With Type 1 Narcolepsy: A Case-Control Study.

2. Comments on Motamedi G, Meador K. Epilepsy and cognition. Epilepsy & behavior 2003;4:S25-S28.

Review 3. Neurodevelopmental effects of fetal antiepileptic drug exposure.

Review 4. Neurocognitive Effects of Antiseizure Medications in Children and Adolescents with Epilepsy.

Review 5. Antiepileptic drugs in women with epilepsy during pregnancy.

6. Neurological and psychiatric sequelae of developmental exposure to antiepileptic drugs.

Review 7. Gene Environment Interactions in the Etiology of Neural Tube Defects.