Francesca Letizia Rocca1, Elena Finotti2, Fabio Pizza3,4, Francesca Ingravallo5, Michela Gatta6, Oliviero Bruni7, Giuseppe Plazzi3,4. 1. Department of Clinical and Experimental Medicine, University of Sassari, Sassari, Italy. 2. Department of Rehabilitation, Child and Adolescent Neuropsychiatry Unit, ULSS 6 Vicenza, Italy. 3. Department of Biomedical and Neuromotor Sciences (DIBINEM), University of Bologna, Bologna, Italy. 4. IRCCS Institute of Neurological Sciences, ASL di Bologna, Bologna, Italy. 5. Department of Medical and Surgical Sciences (DIMEC), University of Bologna, Bologna, Italy. 6. Department of Woman and Child Health, University of Padua, Italy. 7. Department of Developmental Neurology and Psychiatry, Centre for Pediatric Sleep Disorders, Sapienza University, Rome, Italy.
Abstract
STUDY OBJECTIVES: To investigate behavioral aspects and quality of life in children and adolescents with type 1 narcolepsy (NT1). METHODS: We performed a case-control study comparing 29 patients with NT1 versus sex- and age-matched patients with idiopathic epilepsy (n = 39) and healthy controls (n = 39). Behavior and quality of life were evaluated by self-administered questionnaires (Child Behavior Checklist, Pediatric Quality of Life Inventory). Patient groups were contrasted and scale results were correlated with clinical and polysomnographic parameters, and cerebrospinal fluid hypocretin-1 levels. RESULTS: Young patients with NT1 showed increased internalizing problems associated with aggressive behavior. Emotional profile in patients with NT1 positively correlated with age at onset, diagnostic delay, and subjective sleepiness, whereas treatment and disease duration were associated with fewer behavioral problems (attention problems, aggressive behavior, and attention deficit/hyperactivity disorder). Psychosocial health domains of pediatric NT1 were worse than in healthy controls, whereas the physical health domains were comparable. CONCLUSIONS: Young NT1 patients show a discrete pattern of altered behavioral, thought, and mood profile in comparison with healthy controls and with idiopathic epilepsy patients thus suggesting a direct link with sleepiness. Further studies investigating behavior in patients with idiopathic hypersomnia or type 2 narcolepsy are needed to disentangle the role of REM sleep dysfunction and hypocretin deficiency in psychiatric disorders. Symptoms of withdrawal, depression, somatic complaints, thought problems, and aggressiveness were common, NT1 children perceived lower school competencies than healthy children, and their parents also reported worse psychosocial health. Our data suggest that early effective treatment and disease self-awareness should be promoted in NT1 children for their positive effect on behavior and psychosocial health.
STUDY OBJECTIVES: To investigate behavioral aspects and quality of life in children and adolescents with type 1 narcolepsy (NT1). METHODS: We performed a case-control study comparing 29 patients with NT1 versus sex- and age-matched patients with idiopathic epilepsy (n = 39) and healthy controls (n = 39). Behavior and quality of life were evaluated by self-administered questionnaires (Child Behavior Checklist, Pediatric Quality of Life Inventory). Patient groups were contrasted and scale results were correlated with clinical and polysomnographic parameters, and cerebrospinal fluid hypocretin-1 levels. RESULTS: Young patients with NT1 showed increased internalizing problems associated with aggressive behavior. Emotional profile in patients with NT1 positively correlated with age at onset, diagnostic delay, and subjective sleepiness, whereas treatment and disease duration were associated with fewer behavioral problems (attention problems, aggressive behavior, and attention deficit/hyperactivity disorder). Psychosocial health domains of pediatric NT1 were worse than in healthy controls, whereas the physical health domains were comparable. CONCLUSIONS: Young NT1 patients show a discrete pattern of altered behavioral, thought, and mood profile in comparison with healthy controls and with idiopathic epilepsypatients thus suggesting a direct link with sleepiness. Further studies investigating behavior in patients with idiopathic hypersomnia or type 2 narcolepsy are needed to disentangle the role of REM sleep dysfunction and hypocretin deficiency in psychiatric disorders. Symptoms of withdrawal, depression, somatic complaints, thought problems, and aggressiveness were common, NT1 children perceived lower school competencies than healthy children, and their parents also reported worse psychosocial health. Our data suggest that early effective treatment and disease self-awareness should be promoted in NT1 children for their positive effect on behavior and psychosocial health.
Authors: Rosa Peraita-Adrados; Juan J García-Peñas; Luz Ruiz-Falcó; Luis Gutiérrez-Solana; Pilar López-Esteban; José L Vicario; Silvia Miano; Manuel Aparicio-Meix; María-José Martinez-Sopena Journal: Sleep Med Date: 2010-11-02 Impact factor: 3.492
Authors: Zhongxing Zhang; Yves Dauvilliers; Giuseppe Plazzi; Geert Mayer; Gert Jan Lammers; Joan Santamaria; Markku Partinen; Sebastiaan Overeem; Rafael Del Rio Villegas; Karel Sonka; Rosa Peraita-Adrados; Raphaël Heinzer; Aleksandra Wierzbicka; Birgit Högl; Mauro Manconi; Eva Feketeova; Antonio Martins da Silva; Jitka Bušková; Claudio L A Bassetti; Lucie Barateau; Fabio Pizza; Elena Antelmi; Jari K Gool; Rolf Fronczek; Carles Gaig; Ramin Khatami Journal: Nat Sci Sleep Date: 2022-05-31