Literature DB >> 2146514

Sympathetic denervation causes atrial natriuretic peptide-storing granules to appear in the ventricular myocardium of the rat.

A Albino-Teixeira1, J J Polónia, I Azevedo.   

Abstract

Sympathetic denervation of the rat heart was produced by 6-hydroxydopamine. In denervated ventricles abundant "atrial" granules were observed whereas in controls no such granules were seen. Denervated ventricles and atria showed a very high content of atrial natriuretic peptide-like immunoreactivity (greater than 10 times higher than in control animals). We suggest that the sympathetic nervous system exerts a repressive effect upon synthesis of atrial natriuretic peptide-like material and upon the formation of atrial natriuretic peptide-storing granules in the ventricular myocardium.

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Year:  1990        PMID： 2146514     DOI： 10.1007/bf00166971

Source DB:  PubMed          Journal:  Naunyn Schmiedebergs Arch Pharmacol        ISSN： 0028-1298            Impact factor:   3.000


  17 in total

1.  Extra-atrial expression of the gene for atrial natriuretic factor.

Authors:  D G Gardner; C F Deschepper; W F Ganong; S Hane; J Fiddes; J D Baxter; J Lewicki
Journal:  Proc Natl Acad Sci U S A       Date:  1986-09       Impact factor: 11.205

2.  Identification of atrial natriuretic factor within ventricular tissue in hamsters and humans with congestive heart failure.

Authors:  B S Edwards; D M Ackermann; M E Lee; G S Reeder; L E Wold; J C Burnett
Journal:  J Clin Invest       Date:  1988-01       Impact factor: 14.808

3.  Ontogenesis of peripheral adrenergic neurons in the rat: pre- and postnatal observations.

Authors:  J De Champlain; T Malmfors; L Olson; C Sachs
Journal:  Acta Physiol Scand       Date:  1970-10

4.  Evidence for alpha-1 adrenergic receptor regulation of atriopeptin release from the isolated rat heart.

Authors:  M G Currie; W H Newman
Journal:  Biochem Biophys Res Commun       Date:  1986-05-29       Impact factor: 3.575

5.  Ultrastructural changes in blood vessels of perinephritic hypertensive dogs.

Authors:  I Azevedo; J Castro-Tavares; J Garrett
Journal:  Blood Vessels       Date:  1981

6.  Effects of denervation induced by 6-hydroxydopamine on cell nucleus activity of arterial and cardiac cells of the dog.

Authors:  A Sarmento; P Soares-da-Silva; A A Teixeira; I Azevedo
Journal:  J Auton Pharmacol       Date:  1987-06

7.  Immunocytochemical localization of atrial natriuretic factor in the heart and salivary glands.

Authors:  M Cantin; J Gutkowska; G Thibault; R W Milne; S Ledoux; S MinLi; C Chapeau; R Garcia; P Hamet; J Genest
Journal:  Histochemistry       Date:  1984

8.  Structural and functional alterations caused at the extraneuronal level by sympathetic denervation of blood vessels.

Authors:  D Branco; A A Teixeira; I Azevedo; W Osswald
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1984-07       Impact factor: 3.000

9.  Radioimmunoassay of alpha rat atrial natriuretic peptide.

Authors:  J V Anderson; N D Christofides; P Vinas; J Wharton; I M Varndell; J M Polak; S R Bloom
Journal:  Neuropeptides       Date:  1986 Feb-Mar       Impact factor: 3.286

10.  Molecular forms of atrial natriuretic polypeptides in mammalian tissues and plasma.

Authors:  A Miyata; K Kangawa; T Toshimori; T Hatoh; H Matsuo
Journal:  Biochem Biophys Res Commun       Date:  1985-05-31       Impact factor: 3.575
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