Literature DB >> 21463460

The dynamin-related protein DRP-1 and the insulin signaling pathway cooperate to modulate Caenorhabditis elegans longevity.

Christine C Yang1, Diana Chen, Siu Sylvia Lee, Ludivine Walter.   

Abstract

Here, we report that inactivation of the Caenorhabditis elegans dynamin-related protein DRP-1, a key component responsible for mitochondrial fission and conserved from yeast to humans, dramatically enhanced the effect of reduced insulin signaling (IIS) to extend lifespan. This represents the first report of a beneficial impact of manipulating mitochondrial dynamics on animal lifespan and suggests that mitochondrial morphology and IIS cooperate to modulate aging.
© 2011 The Authors. Aging Cell © 2011 Blackwell Publishing Ltd/Anatomical Society of Great Britain and Ireland.

Entities:  

Mesh：

Substances：

Year:  2011        PMID： 21463460      PMCID： PMC3135752          DOI： 10.1111/j.1474-9726.2011.00711.x

Source DB:  PubMed          Journal:  Aging Cell        ISSN： 1474-9718            Impact factor:   9.304


  28 in total

Review 1.  Relationship between increased longevity and stress resistance as assessed through gerontogene mutations in Caenorhabditis elegans.

Authors:  T E Johnson; E de Castro; S Hegi de Castro; J Cypser; S Henderson; P Tedesco
Journal:  Exp Gerontol       Date:  2001-11       Impact factor: 4.032

Review 2.  New insights into the role of mitochondria in aging: mitochondrial dynamics and more.

Authors:  Arnold Y Seo; Anna-Maria Joseph; Debapriya Dutta; Judy C Y Hwang; John P Aris; Christiaan Leeuwenburgh
Journal:  J Cell Sci       Date:  2010-08-01       Impact factor: 5.285

Review 3.  Genetics of lifespan in C. elegans: molecular diversity, physiological complexity, mechanistic simplicity.

Authors:  S Hekimi; J Burgess; F Bussière; Y Meng; C Bénard
Journal:  Trends Genet       Date:  2001-12       Impact factor: 11.639

4.  Regulation of C. elegans DAF-16 and its human ortholog FKHRL1 by the daf-2 insulin-like signaling pathway.

Authors:  R Y Lee; J Hench; G Ruvkun
Journal:  Curr Biol       Date:  2001-12-11       Impact factor: 10.834

5.  A C. elegans mutant that lives twice as long as wild type.

Authors:  C Kenyon; J Chang; E Gensch; A Rudner; R Tabtiang
Journal:  Nature       Date:  1993-12-02       Impact factor: 49.962

6.  The age-1 and daf-2 genes function in a common pathway to control the lifespan of Caenorhabditis elegans.

Authors:  J B Dorman; B Albinder; T Shroyer; C Kenyon
Journal:  Genetics       Date:  1995-12       Impact factor: 4.562

7.  Mitochondrial changes in flight muscles of normal and flightless Drosophila melanogaster with age.

Authors:  R D Sohal
Journal:  J Morphol       Date:  1975-03       Impact factor: 1.804

8.  Mitochondrial electron transport is a key determinant of life span in Caenorhabditis elegans.

Authors:  J Feng; F Bussière; S Hekimi
Journal:  Dev Cell       Date:  2001-11       Impact factor: 12.270

Review 9.  Mitochondrial dynamics in model organisms: what yeasts, worms and flies have taught us about fusion and fission of mitochondria.

Authors:  Benedikt Westermann
Journal:  Semin Cell Dev Biol       Date:  2009-12-17       Impact factor: 7.727

10.  A mutation in the age-1 gene in Caenorhabditis elegans lengthens life and reduces hermaphrodite fertility.

Authors:  D B Friedman; T E Johnson
Journal:  Genetics       Date:  1988-01       Impact factor: 4.562
View more
  32 in total

Review 1.  'Inside Out'- a dialogue between mitochondria and bacteria.

Authors:  Bing Han; Chih-Chun Janet Lin; Guo Hu; Meng C Wang
Journal:  FEBS J       Date:  2018-11-21       Impact factor: 5.542

2.  A uvs-5 strain is deficient for a mitofusin gene homologue, fzo1, involved in maintenance of long life span in Neurospora crassa.

Authors:  Kiminori Kurashima; Michael Chae; Hirokazu Inoue; Shin Hatakeyama; Shuuitsu Tanaka
Journal:  Eukaryot Cell       Date:  2012-12-07

Review 3.  Mitochondrial fusion, fission, and mitochondrial toxicity.

Authors:  Joel N Meyer; Tess C Leuthner; Anthony L Luz
Journal:  Toxicology       Date:  2017-08-05       Impact factor: 4.221

4.  A novel role of the mitochondrial iron-sulfur cluster assembly protein ISCU-1/ISCU in longevity and stress response.

Authors:  Yi Sheng; Guang Yang; Kaitlyn Casey; Shayla Curry; Mason Oliver; Sung Min Han; Christiaan Leeuwenburgh; Rui Xiao
Journal:  Geroscience       Date:  2021-02-01       Impact factor: 7.713

5.  Metabolic alterations caused by the mutation and overexpression of the Tmem135 gene.

Authors:  Wei-Hua Lee; Vijesh J Bhute; Hitoshi Higuchi; Sakae Ikeda; Sean P Palecek; Akihiro Ikeda
Journal:  Exp Biol Med (Maywood)       Date:  2020-06-09

6.  Drp-1-Dependent Mitochondrial Fragmentation Contributes to Cobalt Chloride-Induced Toxicity in Caenorhabditis elegans.

Authors:  Fuli Zheng; Pan Chen; Huangyuan Li; Michael Aschner
Journal:  Toxicol Sci       Date:  2020-09-01       Impact factor: 4.849

Review 7.  In vivo functions of Drp1: lessons learned from yeast genetics and mouse knockouts.

Authors:  Hiromi Sesaki; Yoshihiro Adachi; Yusuke Kageyama; Kie Itoh; Miho Iijima
Journal:  Biochim Biophys Acta       Date:  2013-12-08

Review 8.  Mitochondria and Reactive Oxygen Species in Aging and Age-Related Diseases.

Authors:  Carlotta Giorgi; Saverio Marchi; Ines C M Simoes; Ziyu Ren; Giampaolo Morciano; Mariasole Perrone; Paulina Patalas-Krawczyk; Sabine Borchard; Paulina Jędrak; Karolina Pierzynowska; Jędrzej Szymański; David Q Wang; Piero Portincasa; Grzegorz Węgrzyn; Hans Zischka; Pawel Dobrzyn; Massimo Bonora; Jerzy Duszynski; Alessandro Rimessi; Agnieszka Karkucinska-Wieckowska; Agnieszka Dobrzyn; Gyorgy Szabadkai; Barbara Zavan; Paulo J Oliveira; Vilma A Sardao; Paolo Pinton; Mariusz R Wieckowski
Journal:  Int Rev Cell Mol Biol       Date:  2018-06-22       Impact factor: 6.813

9.  Mfn2 deficiency links age-related sarcopenia and impaired autophagy to activation of an adaptive mitophagy pathway.

Authors:  David Sebastián; Eleonora Sorianello; Jessica Segalés; Andrea Irazoki; Vanessa Ruiz-Bonilla; David Sala; Evarist Planet; Antoni Berenguer-Llergo; Juan Pablo Muñoz; Manuela Sánchez-Feutrie; Natàlia Plana; María Isabel Hernández-Álvarez; Antonio L Serrano; Manuel Palacín; Antonio Zorzano
Journal:  EMBO J       Date:  2016-06-22       Impact factor: 11.598

Review 10.  Interplay of mitochondrial fission-fusion with cell cycle regulation: Possible impacts on stem cell and organismal aging.

Authors:  B Spurlock; Jma Tullet; J L Hartman; K Mitra
Journal:  Exp Gerontol       Date:  2020-03-24       Impact factor: 4.032
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.