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Literature DB >> 11672983

Relationship between increased longevity and stress resistance as assessed through gerontogene mutations in Caenorhabditis elegans.

T E Johnson¹, E de Castro, S Hegi de Castro, J Cypser, S Henderson, P Tedesco.

Abstract

We review the status of the hypothesis that interventions that increase the resistance to stress offer the potential for effective life prolongation and increased health. The work focuses on research in the nematode worm Caenorhabditis elegans and describes both published and unpublished results consistent with this hypothesis. Correlation between stress resistance and longevity among many gerontogene mutants is provided.

Entities: Species

Mesh：

Year: 2001 PMID： 11672983 DOI： 10.1016/s0531-5565(01)00144-9

Source DB: PubMed Journal: Exp Gerontol ISSN： 0531-5565 Impact factor: 4.032

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Cited

42 in total

Review 1. Longevity genes in the nematode Caenorhabditis elegans also mediate increased resistance to stress and prevent disease.

Authors: T E Johnson; S Henderson; S Murakami; E de Castro; S H de Castro; J Cypser; B Rikke; P Tedesco; C Link
Journal: J Inherit Metab Dis Date: 2002-05 Impact factor: 4.982

Review 2. Gadd45 proteins: relevance to aging, longevity and age-related pathologies.

Authors: Alexey A Moskalev; Zeljka Smit-McBride; Mikhail V Shaposhnikov; Ekaterina N Plyusnina; Alex Zhavoronkov; Arie Budovsky; Robi Tacutu; Vadim E Fraifeld
Journal: Ageing Res Rev Date: 2011-10-05 Impact factor: 10.895

3. Molecular characterization of numr-1 and numr-2: genes that increase both resistance to metal-induced stress and lifespan in Caenorhabditis elegans.

Authors: Brooke E Tvermoes; Windy A Boyd; Jonathan H Freedman
Journal: J Cell Sci Date: 2010-05-25 Impact factor: 5.285

Relationship between increased longevity and stress resistance as assessed through gerontogene mutations in Caenorhabditis elegans.

Review 1. Longevity genes in the nematode Caenorhabditis elegans also mediate increased resistance to stress and prevent disease.

Review 2. Gadd45 proteins: relevance to aging, longevity and age-related pathologies.

3. Molecular characterization of numr-1 and numr-2: genes that increase both resistance to metal-induced stress and lifespan in Caenorhabditis elegans.

Review 4. Hormesis and aging in Caenorhabditis elegans.

5. Sex differences in oxidative stress resistance in relation to longevity in Drosophila melanogaster.

6. Hormetic modulation of aging and longevity by mild heat stress.

7. Molecular mechanisms of anti-aging hormetic effects of mild heat stress on human cells.

8. Regulation of aging by unc-13 and sbt-1 in Caenorhabditis elegans is temperature-dependent.

9. Genetic suppression of cryoprotectant toxicity.

10. SLR-2 and JMJC-1 regulate an evolutionarily conserved stress-response network.