BACKGROUND: The neuropsychiatric complications of Parkinson's disease (PD), which include behaviour disturbances such as apathy and the impulse control disorders (ICDs), may have a significant effect on patients with PD and their carers. The contribution of these behaviour disorders to carer burden is less understood. Therefore, the aim of this study was to explore the relationship that apathy and ICDs have with carer burden. METHODS: Non-demented (n = 71) PD-carer dyads (spouse or adult child) participated in the study. The PD participants were divided into three behavioural groups: ICD (n = 21), apathy (n = 22) and controls (n = 28). The three groups were compared for level of burden in their carers by using the Zarit Burden Interview. The PD participants were rated for levels of apathy, impulsivity and motor and psychiatric symptoms. Using a multivariate analysis, we sought the PD-related predictors of carer burden. RESULTS: Significantly, greater burden was seen in carers of PD participants with ICDs (p = 0.002) or apathy (p = 0.004), compared with carers of PD participants without such behavioural disturbances. Linear regression models revealed that attentional ability accounted for burden in carers of the group with apathy, whereas dopaminergic load and depression accounted for burden in carers of the group with impulsivity. CONCLUSION: PD-related behaviour disturbances, such as apathy and ICDs, as well as psychiatric complications, have significant negative implications for burden of care.
BACKGROUND: The neuropsychiatric complications of Parkinson's disease (PD), which include behaviour disturbances such as apathy and the impulse control disorders (ICDs), may have a significant effect on patients with PD and their carers. The contribution of these behaviour disorders to carer burden is less understood. Therefore, the aim of this study was to explore the relationship that apathy and ICDs have with carer burden. METHODS: Non-demented (n = 71) PD-carer dyads (spouse or adult child) participated in the study. The PDparticipants were divided into three behavioural groups: ICD (n = 21), apathy (n = 22) and controls (n = 28). The three groups were compared for level of burden in their carers by using the Zarit Burden Interview. The PDparticipants were rated for levels of apathy, impulsivity and motor and psychiatric symptoms. Using a multivariate analysis, we sought the PD-related predictors of carer burden. RESULTS: Significantly, greater burden was seen in carers of PDparticipants with ICDs (p = 0.002) or apathy (p = 0.004), compared with carers of PDparticipants without such behavioural disturbances. Linear regression models revealed that attentional ability accounted for burden in carers of the group with apathy, whereas dopaminergic load and depression accounted for burden in carers of the group with impulsivity. CONCLUSION:PD-related behaviour disturbances, such as apathy and ICDs, as well as psychiatric complications, have significant negative implications for burden of care.
Authors: David Okai; Sally Askey-Jones; Michael Samuel; Sean S O'Sullivan; K Ray Chaudhuri; Anne Martin; Joel Mack; Richard G Brown; Anthony S David Journal: Neurology Date: 2013-01-16 Impact factor: 9.910
Authors: Maria Jose Catalan; Jose Antonio Molina-Arjona; Pablo Mir; Esther Cubo; Jose Matias Arbelo; Pablo Martinez-Martin Journal: J Neurol Date: 2018-03-20 Impact factor: 4.849
Authors: Kimberly Papay; Sharon X Xie; Matthew Stern; Howard Hurtig; Andrew Siderowf; John E Duda; James Minger; Daniel Weintraub Journal: Neurology Date: 2014-07-18 Impact factor: 9.910
Authors: Jacob D Jones; London C Butterfield; Woojin Song; Jacob Lafo; Paul Mangal; Michael S Okun; Dawn Bowers Journal: J Neuropsychiatry Clin Neurosci Date: 2014-10-31 Impact factor: 2.198
Authors: Emke Maréchal; Benjamin Denoiseux; Ellen Thys; David Crosiers; Barbara Pickut; Patrick Cras Journal: J Neurol Date: 2014-05-14 Impact factor: 4.849