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Literature DB >> 25162776

Anxiety and Depression Are Better Correlates of Parkinson's Disease Quality of Life Than Apathy.

Jacob D Jones¹, London C Butterfield¹, Woojin Song¹, Jacob Lafo¹, Paul Mangal¹, Michael S Okun¹, Dawn Bowers¹.

Abstract

Due to controversy regarding the influence of apathy on quality of life (QoL), the authors examined the independent influence of apathy, depression, and trait anxiety in a nondemented sample of patients with Parkinson disease (PD). Participants (N=107) completed standard self-report measures of QoL and mood/motivation. Analyses investigated the contribution of these measures and empirically derived factor scores on QoL. QoL was predicted by trait anxiety, dysphoria, and decreased interest, with no independent contribution of apathy. Different patterns emerged with respect to domain-specific QoL, with trait anxiety being the strongest predictor across most domains. Anxiety was most widely related to QoL in PD, with minimal contribution of apathy. Future studies should examine different roles of PD mood/motivation symptoms on caregiver QoL.

Entities: Chemical Disease Gene Species

Mesh：

Year: 2014 PMID： 25162776 PMCID： PMC4344415 DOI： 10.1176/appi.neuropsych.13120380

Source DB: PubMed Journal: J Neuropsychiatry Clin Neurosci ISSN： 0895-0172 Impact factor: 2.198

35 in total

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Journal: Mov Disord Date: 2008-07-15 Impact factor: 10.338

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Journal: Mov Disord Date: 2000-11 Impact factor: 10.338

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Journal: Neurology Date: 2006-07-11 Impact factor: 9.910

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Journal: Mov Disord Date: 2002-03 Impact factor: 10.338

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Journal: Neurol Sci Date: 2009-02-03 Impact factor: 3.307

9. Clinical findings, functional abilities and caregiver distress in the early stage of dementia with Lewy bodies (DLB) and Alzheimer's disease (AD).

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Journal: Arch Gerontol Geriatr Date: 2008-12-11 Impact factor: 3.250

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15 in total

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Authors: Jacob D Jones; Michael Marsiske; Michael S Okun; Dawn Bowers
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2. Depressive symptoms precede cognitive impairment in de novo Parkinson's disease patients: Analysis of the PPMI cohort.

Authors: Jacob D Jones; Natalie E Kurniadi; Taylor P Kuhn; Sarah M Szymkowicz; Joseph Bunch; Elizabeth Rahmani
Journal: Neuropsychology Date: 2019-07-25 Impact factor: 3.295

3. Symptom Dimensions of Depression and Apathy and Their Relationship With Cognition in Parkinson's Disease.

Authors: Sarah M Szymkowicz; Vonetta M Dotson; Jacob D Jones; Michael S Okun; Dawn Bowers
Journal: J Int Neuropsychol Soc Date: 2017-10-16 Impact factor: 2.892

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Authors: Jacob D Jones; Paul Mangal; Jacob Lafo; Michael S Okun; Dawn Bowers
Journal: J Neuropsychiatry Clin Neurosci Date: 2016-01-21 Impact factor: 2.198

5. Changes in cognition precede changes in HRQoL among HIV+ males: Longitudinal analysis of the multicenter AIDS cohort study.

Authors: Jacob D Jones; Taylor Kuhn; Andrew Levine; Ned Sacktor; Cynthia A Munro; Linda A Teplin; Gypsyamber D'Souza; Eileen M Martin; James T Becker; Eric N Miller; Charles H Hinkin
Journal: Neuropsychology Date: 2019-03 Impact factor: 3.424

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Authors: Limin Wang; Zhuoyuan Zhong; Jingyang Hu; Xiaoming Rong; Jun Liu; Songhua Xiao; Zhonglin Liu
Journal: BMC Psychiatry Date: 2015-04-14 Impact factor: 3.630