Literature DB >> 21461611

Expression of a novel gene FAM43B repressing cell proliferation is regulated by DNA methylation in hepatocellular carcinoma cell lines.

Xiao Xu1, Rui-Fang Liu, Bing-Bing Wan, Wen-Ming Xing, Jian Huang, Ze-Guang Han.   

Abstract

The epigenetic dysregulation of tumor suppressor genes plays an important role in many cancers, including hepatocellular carcinoma (HCC). In this study, we identified a new gene, family with sequence similarity 43, member B (FAM43B), based on a previous genome-wide approach. FAM43B was significantly downregulated in 60% (24/40) HCC specimens as compared to non-HCC livers. Enforced FAM43B overexpression could suppress cell growth and colony formation in vitro, and induce cell cycle delay, whereas FAM43B knockdown enhanced cell growth. The expression level of FAM43B was found related to the methylation level of FAM43B promoter in HCC cell lines and HCC specimens. The collective data suggest that the expression of FAM43B was regulated by methylation and the epigenetic silencing of FAM43B could contribute to HCC tumorigenesis by regulating cell proliferation.

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Mesh：

Year:  2011        PMID： 21461611     DOI： 10.1007/s11010-011-0800-y

Source DB:  PubMed          Journal:  Mol Cell Biochem        ISSN： 0300-8177            Impact factor:   3.396


  19 in total

1.  Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method.

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Journal:  Methods       Date:  2001-12       Impact factor: 3.608

2.  Complete sequencing and characterization of 21,243 full-length human cDNAs.

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Journal:  Nat Genet       Date:  2003-12-21       Impact factor: 38.330

3.  Promoter methylation of the secreted frizzled-related protein 1 gene SFRP1 is frequent in hepatocellular carcinoma.

Authors:  Yu-Lueng Shih; Rong-Yuan Shyu; Chung-Bao Hsieh; Hung-Cheng Lai; Kuo-Yu Liu; Tang-Yuan Chu; Ya-Wen Lin
Journal:  Cancer       Date:  2006-08-01       Impact factor: 6.860

4.  Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.

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5.  Inactivation of the CDKN2/p16/MTS1 gene is frequently associated with aberrant DNA methylation in all common human cancers.

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6.  Pharmacologic unmasking of epigenetically silenced tumor suppressor genes in esophageal squamous cell carcinoma.

Authors:  Keishi Yamashita; Sunil Upadhyay; Motonobu Osada; Mohammad O Hoque; Yan Xiao; Masaki Mori; Fumiaki Sato; Stephen J Meltzer; David Sidransky
Journal:  Cancer Cell       Date:  2002-12       Impact factor: 31.743

7.  Apoptotic speck protein-like, a highly homologous protein to apoptotic speck protein in the pyrin domain, is silenced by DNA methylation and induces apoptosis in human hepatocellular carcinoma.

Authors:  Takahiko Kubo; Junji Yamamoto; Yuko Shikauchi; Yasuharu Niwa; Kenichi Matsubara; Hirohide Yoshikawa
Journal:  Cancer Res       Date:  2004-08-01       Impact factor: 12.701

8.  p16(INK4) is inactivated by extensive CpG methylation in human hepatocellular carcinoma.

Authors:  Y Matsuda; T Ichida; J Matsuzawa; K Sugimura; H Asakura
Journal:  Gastroenterology       Date:  1999-02       Impact factor: 22.682

9.  Genetic and epigenetic silencing of SCARA5 may contribute to human hepatocellular carcinoma by activating FAK signaling.

Authors:  Jian Huang; Da-Li Zheng; Feng-Song Qin; Na Cheng; Hui Chen; Bing-Bing Wan; Yu-Ping Wang; Hua-Sheng Xiao; Ze-Guang Han
Journal:  J Clin Invest       Date:  2009-12-14       Impact factor: 14.808

10.  The DNA sequence and biological annotation of human chromosome 1.

Authors:  S G Gregory; K F Barlow; K E McLay; R Kaul; D Swarbreck; A Dunham; C E Scott; K L Howe; K Woodfine; C C A Spencer; M C Jones; C Gillson; S Searle; Y Zhou; F Kokocinski; L McDonald; R Evans; K Phillips; A Atkinson; R Cooper; C Jones; R E Hall; T D Andrews; C Lloyd; R Ainscough; J P Almeida; K D Ambrose; F Anderson; R W Andrew; R I S Ashwell; K Aubin; A K Babbage; C L Bagguley; J Bailey; H Beasley; G Bethel; C P Bird; S Bray-Allen; J Y Brown; A J Brown; D Buckley; J Burton; J Bye; C Carder; J C Chapman; S Y Clark; G Clarke; C Clee; V Cobley; R E Collier; N Corby; G J Coville; J Davies; R Deadman; M Dunn; M Earthrowl; A G Ellington; H Errington; A Frankish; J Frankland; L French; P Garner; J Garnett; L Gay; M R J Ghori; R Gibson; L M Gilby; W Gillett; R J Glithero; D V Grafham; C Griffiths; S Griffiths-Jones; R Grocock; S Hammond; E S I Harrison; E Hart; E Haugen; P D Heath; S Holmes; K Holt; P J Howden; A R Hunt; S E Hunt; G Hunter; J Isherwood; R James; C Johnson; D Johnson; A Joy; M Kay; J K Kershaw; M Kibukawa; A M Kimberley; A King; A J Knights; H Lad; G Laird; S Lawlor; D A Leongamornlert; D M Lloyd; J Loveland; J Lovell; M J Lush; R Lyne; S Martin; M Mashreghi-Mohammadi; L Matthews; N S W Matthews; S McLaren; S Milne; S Mistry; M J F Moore; T Nickerson; C N O'Dell; K Oliver; A Palmeiri; S A Palmer; A Parker; D Patel; A V Pearce; A I Peck; S Pelan; K Phelps; B J Phillimore; R Plumb; J Rajan; C Raymond; G Rouse; C Saenphimmachak; H K Sehra; E Sheridan; R Shownkeen; S Sims; C D Skuce; M Smith; C Steward; S Subramanian; N Sycamore; A Tracey; A Tromans; Z Van Helmond; M Wall; J M Wallis; S White; S L Whitehead; J E Wilkinson; D L Willey; H Williams; L Wilming; P W Wray; Z Wu; A Coulson; M Vaudin; J E Sulston; R Durbin; T Hubbard; R Wooster; I Dunham; N P Carter; G McVean; M T Ross; J Harrow; M V Olson; S Beck; J Rogers; D R Bentley; R Banerjee; S P Bryant; D C Burford; W D H Burrill; S M Clegg; P Dhami; O Dovey; L M Faulkner; S M Gribble; C F Langford; R D Pandian; K M Porter; E Prigmore
Journal:  Nature       Date:  2006-05-18       Impact factor: 49.962
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  5 in total

Review 1.  DNA methylation, microRNAs, and their crosstalk as potential biomarkers in hepatocellular carcinoma.

Authors:  Sumadi Lukman Anwar; Ulrich Lehmann
Journal:  World J Gastroenterol       Date:  2014-06-28       Impact factor: 5.742

2.  LHX6 acts as a novel potential tumour suppressor with epigenetic inactivation in lung cancer.

Authors:  W-b Liu; X Jiang; F Han; Y-h Li; H-q Chen; Y Liu; J Cao; J-y Liu
Journal:  Cell Death Dis       Date:  2013-10-24       Impact factor: 8.469

3.  Aberrant DNA methylation in hepatocellular carcinoma tumor suppression (Review).

Authors:  Youhong Dong; Anping Wang
Journal:  Oncol Lett       Date:  2014-07-01       Impact factor: 2.967

4.  Family with sequence similarity 13C (FAM13C) overexpression is an independent prognostic marker in prostate cancer.

Authors:  Christoph Burdelski; Laura Borcherding; Martina Kluth; Claudia Hube-Magg; Nathaniel Melling; Ronald Simon; Christina Möller-Koop; Philipp Weigand; Sarah Minner; Alexander Haese; Hans Uwe Michl; Maria Christina Tsourlakis; Frank Jacobsen; Andrea Hinsch; Corinna Wittmer; Patrick Lebok; Stefan Steurer; Jakob R Izbicki; Guido Sauter; Till Krech; Franziska Büscheck; Till Clauditz; Thorsten Schlomm; Waldemar Wilczak
Journal:  Oncotarget       Date:  2017-05-09

5.  Transcriptome Related to Avoiding Immune Destruction in Nasopharyngeal Cancer in Indonesian Patients Using Next-Generation Sequencing.

Authors:  Risky Hiskia Poluan; Digdo Sudigyo; Gisti Rahmawati; Dicka Wahyu Setiasari; Salsabila Luthfi Sesotyosari; Tirta Wardana; Indwiani Astuti; Didik Setyo Heriyanto; Sagung Rai Indrasari; Cita Herawati; - Afiahayati; Sofia Mubarika Haryana
Journal:  Asian Pac J Cancer Prev       Date:  2020-09-01
  5 in total

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