Literature DB >> 21460823

A more efficient method to generate integration-free human iPS cells.

Keisuke Okita1, Yasuko Matsumura, Yoshiko Sato, Aki Okada, Asuka Morizane, Satoshi Okamoto, Hyenjong Hong, Masato Nakagawa, Koji Tanabe, Ken-ichi Tezuka, Toshiyuki Shibata, Takahiro Kunisada, Masayo Takahashi, Jun Takahashi, Hiroh Saji, Shinya Yamanaka.   

Abstract

We report a simple method, using p53 suppression and nontransforming L-Myc, to generate human induced pluripotent stem cells (iPSCs) with episomal plasmid vectors. We generated human iPSCs from multiple donors, including two putative human leukocyte antigen (HLA)-homozygous donors who match ∼20% of the Japanese population at major HLA loci; most iPSCs are integrated transgene-free. This method may provide iPSCs suitable for autologous and allologous stem-cell therapy in the future.

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Year:  2011        PMID： 21460823     DOI： 10.1038/nmeth.1591

Source DB:  PubMed          Journal:  Nat Methods        ISSN： 1548-7091            Impact factor:   28.547


  23 in total

1.  Twelve years' experience with national sharing of HLA-matched cadaveric kidneys for transplantation.

Authors:  S K Takemoto; P I Terasaki; D W Gjertson; J M Cecka
Journal:  N Engl J Med       Date:  2000-10-12       Impact factor: 91.245

2.  Generation of dopaminergic neurons and pigmented epithelia from primate ES cells by stromal cell-derived inducing activity.

Authors:  Hiroshi Kawasaki; Hirofumi Suemori; Kenji Mizuseki; Kiichi Watanabe; Fumi Urano; Hiroshi Ichinose; Masatoshi Haruta; Masayo Takahashi; Kanako Yoshikawa; Shin-Ichi Nishikawa; Norio Nakatsuji; Yoshiki Sasai
Journal:  Proc Natl Acad Sci U S A       Date:  2002-01-29       Impact factor: 11.205

3.  Dental pulp cells for induced pluripotent stem cell banking.

Authors:  N Tamaoki; K Takahashi; T Tanaka; T Ichisaka; H Aoki; T Takeda-Kawaguchi; K Iida; T Kunisada; T Shibata; S Yamanaka; K Tezuka
Journal:  J Dent Res       Date:  2010-06-16       Impact factor: 6.116

4.  HLA-haplotype banking and iPS cells.

Authors:  Norio Nakatsuji; Fumiaki Nakajima; Katsushi Tokunaga
Journal:  Nat Biotechnol       Date:  2008-07       Impact factor: 54.908

5.  In vitro differentiation of retinal cells from human pluripotent stem cells by small-molecule induction.

Authors:  Fumitaka Osakada; Zi-Bing Jin; Yasuhiko Hirami; Hanako Ikeda; Teruko Danjyo; Kiichi Watanabe; Yoshiki Sasai; Masayo Takahashi
Journal:  J Cell Sci       Date:  2009-08-11       Impact factor: 5.285

6.  Efficient selection for high-expression transfectants with a novel eukaryotic vector.

Authors:  H Niwa; K Yamamura; J Miyazaki
Journal:  Gene       Date:  1991-12-15       Impact factor: 3.688

7.  Suppression of induced pluripotent stem cell generation by the p53-p21 pathway.

Authors:  Hyenjong Hong; Kazutoshi Takahashi; Tomoko Ichisaka; Takashi Aoi; Osami Kanagawa; Masato Nakagawa; Keisuke Okita; Shinya Yamanaka
Journal:  Nature       Date:  2009-08-09       Impact factor: 49.962

8.  Generation of germline-competent induced pluripotent stem cells.

Authors:  Keisuke Okita; Tomoko Ichisaka; Shinya Yamanaka
Journal:  Nature       Date:  2007-06-06       Impact factor: 49.962

9.  The impact of human leukocyte antigen matching on transplant complications and immunosuppression dosage.

Authors:  Selda Emre Aydingoz; Steven K Takemoto; Brett W Pinsky; Paolo R Salvalaggio; Krista L Lentine; Lisa Willoughby; Beverly Hoover; Thomas A Burroughs; Mark A Schnitzler; Ralph Graff
Journal:  Hum Immunol       Date:  2007-03-15       Impact factor: 2.850

10.  piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells.

Authors:  Knut Woltjen; Iacovos P Michael; Paria Mohseni; Ridham Desai; Maria Mileikovsky; Riikka Hämäläinen; Rebecca Cowling; Wei Wang; Pentao Liu; Marina Gertsenstein; Keisuke Kaji; Hoon-Ki Sung; Andras Nagy
Journal:  Nature       Date:  2009-03-01       Impact factor: 49.962
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  742 in total

Review 1.  Induced pluripotent stem cells--opportunities for disease modelling and drug discovery.

Authors:  Marica Grskovic; Ashkan Javaherian; Berta Strulovici; George Q Daley
Journal:  Nat Rev Drug Discov       Date:  2011-11-11       Impact factor: 84.694

2.  Efficient correction of hemoglobinopathy-causing mutations by homologous recombination in integration-free patient iPSCs.

Authors:  Mo Li; Keiichiro Suzuki; Jing Qu; Preeti Saini; Ilir Dubova; Fei Yi; Jungmin Lee; Ignacio Sancho-Martinez; Guang-Hui Liu; Juan Carlos Izpisua Belmonte
Journal:  Cell Res       Date:  2011-11-22       Impact factor: 25.617

3.  Non-viral iPSCs: a safe way for therapy?

Authors:  Weiqi Zhang; Di Guan; Jing Qu; Weizhou Zhang; Guang-Hui Liu
Journal:  Protein Cell       Date:  2012-04       Impact factor: 14.870

4.  Induced neural stem cells: a new tool for studying neural development and neurological disorders.

Authors:  Guang-Hui Liu; Fei Yi; Keiichiro Suzuki; Jing Qu; Juan Carlos Izpisua Belmonte
Journal:  Cell Res       Date:  2012-05-01       Impact factor: 25.617

5.  A BAG3 chaperone complex maintains cardiomyocyte function during proteotoxic stress.

Authors:  Luke M Judge; Juan A Perez-Bermejo; Annie Truong; Alexandre Js Ribeiro; Jennie C Yoo; Christina L Jensen; Mohammad A Mandegar; Nathaniel Huebsch; Robyn M Kaake; Po-Lin So; Deepak Srivastava; Beth L Pruitt; Nevan J Krogan; Bruce R Conklin
Journal:  JCI Insight       Date:  2017-07-20

6.  Impaired mitochondrial dynamics underlie axonal defects in hereditary spastic paraplegias.

Authors:  Kyle Denton; Yongchao Mou; Chong-Chong Xu; Dhruvi Shah; Jaerak Chang; Craig Blackstone; Xue-Jun Li
Journal:  Hum Mol Genet       Date:  2018-07-15       Impact factor: 6.150

7.  Genetic risk for Parkinson's disease correlates with alterations in neuronal manganese sensitivity between two human subjects.

Authors:  Asad A Aboud; Andrew M Tidball; Kevin K Kumar; M Diana Neely; Kevin C Ess; Keith M Erikson; Aaron B Bowman
Journal:  Neurotoxicology       Date:  2012-10-22       Impact factor: 4.294

8.  Patient-derived skeletal dysplasia induced pluripotent stem cells display abnormal chondrogenic marker expression and regulation by BMP2 and TGFβ1.

Authors:  Biagio Saitta; Jenna Passarini; Dhruv Sareen; Loren Ornelas; Anais Sahabian; Shilpa Argade; Deborah Krakow; Daniel H Cohn; Clive N Svendsen; David L Rimoin
Journal:  Stem Cells Dev       Date:  2014-04-01       Impact factor: 3.272

Review 9.  Chromosome therapy. Correction of large chromosomal aberrations by inducing ring chromosomes in induced pluripotent stem cells (iPSCs).

Authors:  Taehyun Kim; Marina Bershteyn; Anthony Wynshaw-Boris
Journal:  Nucleus       Date:  2014 Sep-Oct       Impact factor: 4.197

10.  Biallelic truncating mutations in FMN2, encoding the actin-regulatory protein Formin 2, cause nonsyndromic autosomal-recessive intellectual disability.

Authors:  Rosalind Law; Tracy Dixon-Salazar; Julie Jerber; Na Cai; Ansar A Abbasi; Maha S Zaki; Kirti Mittal; Stacey B Gabriel; Muhammad Arshad Rafiq; Valeed Khan; Maria Nguyen; Ghazanfar Ali; Brett Copeland; Eric Scott; Nasim Vasli; Anna Mikhailov; Muhammad Nasim Khan; Danielle M Andrade; Muhammad Ayaz; Muhammad Ansar; Muhammad Ayub; John B Vincent; Joseph G Gleeson
Journal:  Am J Hum Genet       Date:  2014-12-04       Impact factor: 11.025
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