OBJECTIVE: The objective of the study was to describe neurodevelopmental outcome at the age of 4.5 years in 216 children, born after expectant management of severe early-onset hypertensive complications of pregnancy. STUDY DESIGN: This was a prospective follow-up study until age 4.5 years from maternal admission onward. Developmental outcome measurements included child intelligence quotient and behavioral, motor, and neurological outcome. Abnormal composite outcome (perinatal mortality or abnormal developmental outcome) was studied in relation to gestational age (GA), birthweight (BW), and perinatal variables. RESULTS: Fetal and neonatal mortality was 9% and 8%, respectively. Of the 178 survivors, 149 (84%) were seen for follow-up. Mean GA was 31.4 weeks and 90% were born growth restricted. Abnormal developmental outcome occurred in 20% and abnormal composite outcome in 37%. CONCLUSION: Perinatal mortality or abnormal child development occurs in one third of pregnancies with early-onset and severe hypertensive complications and is highest in the lowest GA and BW ranges.
OBJECTIVE: The objective of the study was to describe neurodevelopmental outcome at the age of 4.5 years in 216 children, born after expectant management of severe early-onset hypertensive complications of pregnancy. STUDY DESIGN: This was a prospective follow-up study until age 4.5 years from maternal admission onward. Developmental outcome measurements included child intelligence quotient and behavioral, motor, and neurological outcome. Abnormal composite outcome (perinatal mortality or abnormal developmental outcome) was studied in relation to gestational age (GA), birthweight (BW), and perinatal variables. RESULTS: Fetal and neonatal mortality was 9% and 8%, respectively. Of the 178 survivors, 149 (84%) were seen for follow-up. Mean GA was 31.4 weeks and 90% were born growth restricted. Abnormal developmental outcome occurred in 20% and abnormal composite outcome in 37%. CONCLUSION: Perinatal mortality or abnormal child development occurs in one third of pregnancies with early-onset and severe hypertensive complications and is highest in the lowest GA and BW ranges.
Authors: Vanessa R Kay; Matthew T Rätsep; Lindsay S Cahill; Andrew F Hickman; Bruno Zavan; Margaret E Newport; Jacob Ellegood; Christine L Laliberte; James N Reynolds; Peter Carmeliet; Chandrakant Tayade; John G Sled; B Anne Croy Journal: Physiol Genomics Date: 2018-08-17 Impact factor: 3.107
Authors: Serena B Gumusoglu; Akanksha S S Chilukuri; Donna A Santillan; Mark K Santillan; Hanna E Stevens Journal: Trends Neurosci Date: 2020-03-06 Impact factor: 13.837
Authors: Alissa R Carver; Maria Andrikopoulou; Jun Lei; Esther Tamayo; Phyllis Gamble; Zhipeng Hou; Jiangyang Zhang; Susumu Mori; George R Saade; Maged M Costantine; Irina Burd Journal: PLoS One Date: 2014-06-25 Impact factor: 3.240