Literature DB >> 21458804

Prevalence of hypospadias in grandsons of women exposed to diethylstilbestrol during pregnancy: a multigenerational national cohort study.

Nicolas Kalfa1, Françoise Paris, Marie-Odile Soyer-Gobillard, Jean-Pierre Daures, Charles Sultan.   

Abstract

Prenatal diethylstilbestrol (DES)-exposed mice have raised the suspicion of a transgenerational effect in the occurrence of genital malformation in males. This nationwide cohort study in collaboration with a French association of DES-exposed women studied 529 families and showed that a significant proportion of boys born to DES daughters exhibited hypospadias with no other molecular defects identified.
Copyright © 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.

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Year:  2011        PMID： 21458804     DOI： 10.1016/j.fertnstert.2011.02.047

Source DB:  PubMed          Journal:  Fertil Steril        ISSN： 0015-0282            Impact factor:   7.329


  25 in total

Review 1.  Pharmacologic and Environmental Endocrine Disruptors in the Pathogenesis of Hypospadias: a Review.

Authors:  Rajiv Raghavan; Megan E Romano; Margaret R Karagas; Frank J Penna
Journal:  Curr Environ Health Rep       Date:  2018-12

2.  Association of Exposure to Diethylstilbestrol During Pregnancy With Multigenerational Neurodevelopmental Deficits.

Authors:  Marianthi-Anna Kioumourtzoglou; Brent A Coull; Éilis J O'Reilly; Alberto Ascherio; Marc G Weisskopf
Journal:  JAMA Pediatr       Date:  2018-07-01       Impact factor: 16.193

3.  Prenatal diethylstilbestrol induces malformation of the external genitalia of male and female mice and persistent second-generation developmental abnormalities of the external genitalia in two mouse strains.

Authors:  Phitsanu Mahawong; Adriane Sinclair; Yi Li; Bruce Schlomer; Esequiel Rodriguez; Max M Ferretti; Baomei Liu; Laurence S Baskin; Gerald R Cunha
Journal:  Differentiation       Date:  2014-10-14       Impact factor: 3.880

4.  No difference in congenital anomalies prevalence irrespective of insemination methods and freezing procedure: cohort study over fourteen years of an ART population in the south of France.

Authors:  Any Beltran Anzola; Vanessa Pauly; Debbie Montjean; Line Meddeb; Cendrine Geoffroy-Siraudin; Roland Sambuc; Pierre Boyer; Marie-José Gervoise-Boyer
Journal:  J Assist Reprod Genet       Date:  2017-03-23       Impact factor: 3.412

Review 5.  Minireview: transgenerational epigenetic inheritance: focus on endocrine disrupting compounds.

Authors:  Emilie F Rissman; Mazhar Adli
Journal:  Endocrinology       Date:  2014-06-02       Impact factor: 4.736

6.  Transgenerational effects of di-(2-ethylhexyl) phthalate on testicular germ cell associations and spermatogonial stem cells in mice.

Authors:  Timothy J Doyle; Jennifer L Bowman; Veronica L Windell; Derek J McLean; Kwan Hee Kim
Journal:  Biol Reprod       Date:  2013-05-02       Impact factor: 4.285

7.  Genome-wide DNA methylation profiling of CpG islands in hypospadias.

Authors:  Shweta Choudhry; Archana Deshpande; Liang Qiao; Kenneth Beckman; Saunak Sen; Laurence S Baskin
Journal:  J Urol       Date:  2012-08-17       Impact factor: 7.450

Review 8.  Endocrine disruptor induction of epigenetic transgenerational inheritance of disease.

Authors:  Michael K Skinner
Journal:  Mol Cell Endocrinol       Date:  2014-07-31       Impact factor: 4.102

Review 9.  Exposure to diethylstilbestrol during sensitive life stages: a legacy of heritable health effects.

Authors:  Casey E Reed; Suzanne E Fenton
Journal:  Birth Defects Res C Embryo Today       Date:  2013-06

Review 10.  Obesogenic Endocrine Disrupting Chemicals: Identifying Knowledge Gaps.

Authors:  Almudena Veiga-Lopez; Yong Pu; Jeremy Gingrich; Vasantha Padmanabhan
Journal:  Trends Endocrinol Metab       Date:  2018-07-13       Impact factor: 12.015
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