| Literature DB >> 21458255 |
Zhijuan Wang1, Juan Zhang1, Peng Chen6, Xiaozhu Zhou1, Yanli Yang2, Shixin Wu1, Li Niu3, Yu Han4, Lianhui Wang5, Peng Chen6, Freddy Boey2, Qichun Zhang1, Bo Liedberg2, Hua Zhang2.
Abstract
Reduced graphene oxide (rGO)-modified glassy carbon electrode is used to detect the methicillin-resistant Staphylococcus aureus (MRSA) DNA by using electrochemical impedance spectroscopy. Our experiments confirm that ssDNA, before and after hybridization with target DNA, are successfully anchored on the rGO surface. After the probe DNA, pre-adsorbed on rGO electrode, hybridizes with target DNA, the measured impedance increases dramatically. It provides a new method to detect DNA with high sensitivity (10(-13)M, i.e., 100 fM) and selectivity.Entities:
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Year: 2011 PMID： 21458255 DOI： 10.1016/j.bios.2011.03.002
Source DB: PubMed Journal: Biosens Bioelectron ISSN： 0956-5663 Impact factor: 10.618