BACKGROUND: A liquid meal tolerance test (LMTT) has been proposed as a useful alternative to more labor-intensive methods of assessing insulin sensitivity and secretion. OBJECTIVE: This substudy, conducted at the conclusion of a randomized, double-blind crossover trial, compared insulin sensitivity indices from a LMTT (Matsuda insulin sensitivity index [MISI] and LMTT disposition index [LMTT-DI]) with indices derived from minimal model analysis of results from the insulin-modified intravenous glucose tolerance test (IVGTT) (insulin sensitivity index [S(I)] and disposition index [DI]). RESULTS:Participants included men (n = 16) and women (n = 8) without diabetes but with increased abdominal adiposity (waist circumference ≥102 cm and ≥89 cm, respectively) and mean age of 48.9 years. The correlation between S(I) and the MISI was 0.776 (P < 0.0001). The respective associations between S(I) and MISI with waist circumference (r = -0.445 and -0.554, both P < 0.05) and body mass index were similar (r = -0.500 and -0.539, P < 0.05). The correlation between DI and LMTT-DI was 0.604 (P = 0.002). CONCLUSIONS: These results indicate that indices of insulin sensitivity and secretion derived from the LMTT correlate well with those from the insulin-modified IVGTT with minimal model analysis, suggesting that they may be useful for application in clinical and population studies of glucose homeostasis.
RCT Entities:
BACKGROUND: A liquid meal tolerance test (LMTT) has been proposed as a useful alternative to more labor-intensive methods of assessing insulin sensitivity and secretion. OBJECTIVE: This substudy, conducted at the conclusion of a randomized, double-blind crossover trial, compared insulin sensitivity indices from a LMTT (Matsuda insulin sensitivity index [MISI] and LMTT disposition index [LMTT-DI]) with indices derived from minimal model analysis of results from the insulin-modified intravenous glucose tolerance test (IVGTT) (insulin sensitivity index [S(I)] and disposition index [DI]). RESULTS:Participants included men (n = 16) and women (n = 8) without diabetes but with increased abdominal adiposity (waist circumference ≥102 cm and ≥89 cm, respectively) and mean age of 48.9 years. The correlation between S(I) and the MISI was 0.776 (P < 0.0001). The respective associations between S(I) and MISI with waist circumference (r = -0.445 and -0.554, both P < 0.05) and body mass index were similar (r = -0.500 and -0.539, P < 0.05). The correlation between DI and LMTT-DI was 0.604 (P = 0.002). CONCLUSIONS: These results indicate that indices of insulin sensitivity and secretion derived from the LMTT correlate well with those from the insulin-modified IVGTT with minimal model analysis, suggesting that they may be useful for application in clinical and population studies of glucose homeostasis.
Authors: A J Wanders; M Alssema; E J P de Koning; S le Cessie; J H de Vries; P L Zock; F R Rosendaal; M den Heijer; R de Mutsert Journal: Eur J Clin Nutr Date: 2016-11-09 Impact factor: 4.016
Authors: Chioma Izzi-Engbeaya; Alexander N Comninos; Sophie A Clarke; Anne Jomard; Lisa Yang; Sophie Jones; Ali Abbara; Shakunthala Narayanaswamy; Pei Chia Eng; Deborah Papadopoulou; Julia K Prague; Paul Bech; Ian F Godsland; Paul Bassett; Caroline Sands; Stephane Camuzeaux; Maria Gomez-Romero; Jake T M Pearce; Matthew R Lewis; Elaine Holmes; Jeremy K Nicholson; Tricia Tan; Risheka Ratnasabapathy; Ming Hu; Gaelle Carrat; Lorenzo Piemonti; Marco Bugliani; Piero Marchetti; Paul R Johnson; Stephen J Hughes; A M James Shapiro; Guy A Rutter; Waljit S Dhillo Journal: Diabetes Obes Metab Date: 2018-08-16 Impact factor: 6.577
Authors: Marion L Vetter; Thomas A Wadden; Karen L Teff; Zahra F Khan; Raymond Carvajal; Scott Ritter; Reneé H Moore; Jesse L Chittams; Alex Iagnocco; Kenric Murayama; Gary Korus; Noel N Williams; Michael R Rickels Journal: Diabetes Date: 2014-09-09 Impact factor: 9.461