Literature DB >> 21455637

Expression of tankyrase 1 in gastric cancer and its correlation with telomerase activity.

Jinbo Gao1, Jinghui Zhang, Yaoping Long, Yuan Tian, Xiaoming Lu.   

Abstract

Tankyrase 1, which enhances telomerase access to telomeres, plays an important role in telomere maintenance. The aim of this study was to determine the expression and potential role of tankyrase 1 in gastric cancer development and progression. We examined the expression of tankyrase 1 by RT-PCR and Western blotting, and assessed telomerase activity by TRAP-ELISA method in gastric cancer and adjacent normal tissues. We found that tankyrase 1 expression was significantly up-regulated in gastric cancer tissues compared to normal corresponding tissues. Tankyrase 1 over-expression by gastric cancerous tissue was significantly associated with tumor histology differentiation and tumor stage. Moreover, tankyrase 1 expression was significantly correlation with telomerase activity. Our results indicate that tankyrase 1 over-expression may play an important role in gastric cancer development and progression. Tankyrase 1 may be used as a biomarker of gastric cancer and may serve as a target for cancer therapy.

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Year:  2011        PMID： 21455637     DOI： 10.1007/s12253-011-9369-8

Source DB:  PubMed          Journal:  Pathol Oncol Res        ISSN： 1219-4956            Impact factor:   3.201


  26 in total

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  14 in total

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Journal:  J Gastrointest Oncol       Date:  2022-04

3.  Unravelling the Mechanistic Role of Quinazolinone Pharmacophore in the Inhibitory Activity of Bis-quinazolinone Derivative on Tankyrase-1 in the Treatment of Colorectal Cancer (CRC) and Non-small Cell Lung Cancer (NSCLC): A Computational Approach.

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Authors:  Wenshu Xu; Yu Heng Lau; Gerhard Fischer; Yaw Sing Tan; Anasuya Chattopadhyay; Marc de la Roche; Marko Hyvönen; Chandra Verma; David R Spring; Laura S Itzhaki
Journal:  J Am Chem Soc       Date:  2017-02-07       Impact factor: 16.383
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