Literature DB >> 21447162

The self-organizing fractal theory as a universal discovery method: the phenomenon of life.

Alexei Kurakin1.   

Abstract

A universal discovery method potentially applicable to all disciplines studying organizational phenomena has been developed. This method takes advantage of a new form of global symmetry, namely, scale-invariance of self-organizational dynamics of energy/matter at all levels of organizational hierarchy, from elementary particles through cells and organisms to the Universe as a whole. The method is based on an alternative conceptualization of physical reality postulating that the energy/matter comprising the Universe is far from equilibrium, that it exists as a flow, and that it develops via self-organization in accordance with the empirical laws of nonequilibrium thermodynamics. It is postulated that the energy/matter flowing through and comprising the Universe evolves as a multiscale, self-similar structure-process, i.e., as a self-organizing fractal. This means that certain organizational structures and processes are scale-invariant and are reproduced at all levels of the organizational hierarchy. Being a form of symmetry, scale-invariance naturally lends itself to a new discovery method that allows for the deduction of missing information by comparing scale-invariant organizational patterns across different levels of the organizational hierarchy.An application of the new discovery method to life sciences reveals that moving electrons represent a keystone physical force (flux) that powers, animates, informs, and binds all living structures-processes into a planetary-wide, multiscale system of electron flow/circulation, and that all living organisms and their larger-scale organizations emerge to function as electron transport networks that are supported by and, at the same time, support the flow of electrons down the Earth's redox gradient maintained along the core-mantle-crust-ocean-atmosphere axis of the planet. The presented findings lead to a radically new perspective on the nature and origin of life, suggesting that living matter is an organizational state/phase of nonliving matter and a natural consequence of the evolution and self-organization of nonliving matter.The presented paradigm opens doors for explosive advances in many disciplines, by uniting them within a single conceptual framework and providing a discovery method that allows for the systematic generation of knowledge through comparison and complementation of empirical data across different sciences and disciplines.

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Year:  2011        PMID: 21447162      PMCID: PMC3080324          DOI: 10.1186/1742-4682-8-4

Source DB:  PubMed          Journal:  Theor Biol Med Model        ISSN: 1742-4682            Impact factor:   2.432


  212 in total

1.  Evolutionarily conserved pathways of energetic connectivity in protein families.

Authors:  S W Lockless; R Ranganathan
Journal:  Science       Date:  1999-10-08       Impact factor: 47.728

2.  Long-distance charge transport in duplex DNA: the phonon-assisted polaron-like hopping mechanism.

Authors:  P T Henderson; D Jones; G Hampikian; Y Kan; G B Schuster
Journal:  Proc Natl Acad Sci U S A       Date:  1999-07-20       Impact factor: 11.205

3.  Translation of chloroplast psbA mRNA is modulated in the light by counteracting oxidizing and reducing activities.

Authors:  T Trebitsh; A Levitan; A Sofer; A Danon
Journal:  Mol Cell Biol       Date:  2000-02       Impact factor: 4.272

Review 4.  The metabolic implications of intracellular circulation.

Authors:  P W Hochachka
Journal:  Proc Natl Acad Sci U S A       Date:  1999-10-26       Impact factor: 11.205

Review 5.  Catalytic promiscuity and the evolution of new enzymatic activities.

Authors:  P J O'Brien; D Herschlag
Journal:  Chem Biol       Date:  1999-04

6.  Proton transfer from the bulk to the bound ubiquinone Q(B) of the reaction center in chromatophores of Rhodobacter sphaeroides: retarded conveyance by neutral water.

Authors:  O A Gopta; D A Cherepanov; W Junge; A Y Mulkidjanian
Journal:  Proc Natl Acad Sci U S A       Date:  1999-11-09       Impact factor: 11.205

Review 7.  Cytoarchitecture and physical properties of cytoplasm: volume, viscosity, diffusion, intracellular surface area.

Authors:  K Luby-Phelps
Journal:  Int Rev Cytol       Date:  2000

8.  Diminished aqueous microviscosity of tumors in murine models measured with in vivo radiofrequency electron paramagnetic resonance.

Authors:  H J Halpern; G V Chandramouli; E D Barth; C Yu; M Peric; D J Grdina; B A Teicher
Journal:  Cancer Res       Date:  1999-11-15       Impact factor: 12.701

9.  Regulation of the OxyR transcription factor by hydrogen peroxide and the cellular thiol-disulfide status.

Authors:  F Aslund; M Zheng; J Beckwith; G Storz
Journal:  Proc Natl Acad Sci U S A       Date:  1999-05-25       Impact factor: 11.205

Review 10.  Biologic and pharmacologic regulation of mammalian glutathione synthesis.

Authors:  O W Griffith
Journal:  Free Radic Biol Med       Date:  1999-11       Impact factor: 7.376

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  8 in total

1.  Computational inference of mRNA stability from histone modification and transcriptome profiles.

Authors:  Chengyang Wang; Rui Tian; Qian Zhao; Han Xu; Clifford A Meyer; Cheng Li; Yong Zhang; X Shirley Liu
Journal:  Nucleic Acids Res       Date:  2012-04-10       Impact factor: 16.971

2.  Melatonin and abeta, macular degeneration and alzheimers disease: same disease, different outcomes?

Authors:  Bajic Vladan; Isabella Panfoli
Journal:  Med Hypothesis Discov Innov Ophthalmol       Date:  2012

3.  Primal eukaryogenesis: on the communal nature of precellular States, ancestral to modern life.

Authors:  Richard Egel
Journal:  Life (Basel)       Date:  2012-01-23

Review 4.  Fundamental awareness: A framework for integrating science, philosophy and metaphysics.

Authors:  Neil D Theise; Menas C Kafatos
Journal:  Commun Integr Biol       Date:  2016-05-12

Review 5.  Heterogeneous Heat Absorption Is Complementary to Radiotherapy.

Authors:  Andras Szasz
Journal:  Cancers (Basel)       Date:  2022-02-11       Impact factor: 6.639

6.  Soft Tissue Hybrid Model for Real-Time Simulations.

Authors:  Mario R Moreno-Guerra; Oscar Martínez-Romero; Luis Manuel Palacios-Pineda; Daniel Olvera-Trejo; José A Diaz-Elizondo; Eduardo Flores-Villalba; Jorge V L da Silva; Alex Elías-Zúñiga; Ciro A Rodriguez
Journal:  Polymers (Basel)       Date:  2022-03-30       Impact factor: 4.329

7.  Perspectives on Complexity, Chaos and Thermodynamics in Environmental Pathology.

Authors:  Maurizio Manera
Journal:  Int J Environ Res Public Health       Date:  2021-05-27       Impact factor: 3.390

Review 8.  Fractal dimension of chromatin: potential molecular diagnostic applications for cancer prognosis.

Authors:  Konradin Metze
Journal:  Expert Rev Mol Diagn       Date:  2013-09       Impact factor: 5.225

  8 in total

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