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Literature DB >> 10099128

Catalytic promiscuity and the evolution of new enzymatic activities.

Abstract

Several contemporary enzymes catalyze alternative reactions distinct from their normal biological reactions. In some cases the alternative reaction is similar to a reaction that is efficiently catalyzed by an evolutionary related enzyme. Alternative activities could have played an important role in the diversification of enzymes by providing a duplicated gene a head start towards being captured by adaptive evolution.

Mesh：

Substances：
Enzymes

Year: 1999 PMID： 10099128 DOI： 10.1016/S1074-5521(99)80033-7

Source DB: PubMed Journal: Chem Biol ISSN： 1074-5521

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Cited

209 in total

1. Catalytic and binding poly-reactivities shared by two unrelated proteins: The potential role of promiscuity in enzyme evolution.

Authors: L C James; D S Tawfik
Journal: Protein Sci Date: 2001-12 Impact factor: 6.725

2. One site fits both: a model for the ternary complex of folate + NADPH in R67 dihydrofolate reductase, a D2 symmetric enzyme.

Authors: E E Howell; U Shukla; S N Hicks; R D Smiley; L A Kuhn; M I Zavodszky
Journal: J Comput Aided Mol Des Date: 2001-11 Impact factor: 3.686

3. Mimicking natural evolution in vitro: an N-acetylneuraminate lyase mutant with an increased dihydrodipicolinate synthase activity.

Authors: Andreas C Joerger; Sebastian Mayer; Alan R Fersht
Journal: Proc Natl Acad Sci U S A Date: 2003-04-23 Impact factor: 11.205

10. Structure and mechanism of a bacterial haloalcohol dehalogenase: a new variation of the short-chain dehydrogenase/reductase fold without an NAD(P)H binding site.

Authors: R M de Jong; J J W Tiesinga; H J Rozeboom; K H Kalk; L Tang; D B Janssen; B W Dijkstra
Journal: EMBO J Date: 2003-10-01 Impact factor: 11.598

Catalytic promiscuity and the evolution of new enzymatic activities.

1. Catalytic and binding poly-reactivities shared by two unrelated proteins: The potential role of promiscuity in enzyme evolution.

2. One site fits both: a model for the ternary complex of folate + NADPH in R67 dihydrofolate reductase, a D2 symmetric enzyme.

3. Mimicking natural evolution in vitro: an N-acetylneuraminate lyase mutant with an increased dihydrodipicolinate synthase activity.

4. Cryptic genetic variation promotes rapid evolutionary adaptation in an RNA enzyme.

5. The Streptomyces-produced antibiotic fosfomycin is a promiscuous substrate for archaeal isopentenyl phosphate kinase.

Review 6. Biological phosphoryl-transfer reactions: understanding mechanism and catalysis.

Review 7. Many paths to methyltransfer: a chronicle of convergence.

Review 8. Target selection and determination of function in structural genomics.

Review 9. Enzyme (re)design: lessons from natural evolution and computation.

10. Structure and mechanism of a bacterial haloalcohol dehalogenase: a new variation of the short-chain dehydrogenase/reductase fold without an NAD(P)H binding site.