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Literature DB >> 21445070

Next-generation association studies for complex traits.

Abstract

A new study successfully applies complementary whole-genome sequencing and imputation approaches to establish robust disease associations in an isolated population. This strategy is poised to help elucidate the role of variants at the low end of the allele frequency spectrum in the genetic architecture of complex traits.

Entities: Disease Gene Mutation Species

Mesh：

Substances：

Year: 2011 PMID： 21445070 PMCID： PMC3435533 DOI： 10.1038/ng0411-287

Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330

5 in total

Review 1. Use of population isolates for mapping complex traits.

Authors: L Peltonen; A Palotie; K Lange
Journal: Nat Rev Genet Date: 2000-12 Impact factor: 53.242

Review 2. Rare variant association analysis methods for complex traits.

Authors: Jennifer Asimit; Eleftheria Zeggini
Journal: Annu Rev Genet Date: 2010 Impact factor: 16.830

3. A rare variant in MYH6 is associated with high risk of sick sinus syndrome.

Authors: Hilma Holm; Daniel F Gudbjartsson; Patrick Sulem; Gisli Masson; Hafdis Th Helgadottir; Carlo Zanon; Olafur Th Magnusson; Agnar Helgason; Jona Saemundsdottir; Arnaldur Gylfason; Hrafnhildur Stefansdottir; Solveig Gretarsdottir; Stefan E Matthiasson; Gu Mundur Thorgeirsson; Aslaug Jonasdottir; Asgeir Sigurdsson; Hreinn Stefansson; Thomas Werge; Thorunn Rafnar; Lambertus A Kiemeney; Babar Parvez; Raafia Muhammad; Dan M Roden; Dawood Darbar; Gudmar Thorleifsson; G Bragi Walters; Augustine Kong; Unnur Thorsteinsdottir; David O Arnar; Kari Stefansson
Journal: Nat Genet Date: 2011-03-06 Impact factor: 38.330

4. A map of human genome variation from population-scale sequencing.

Authors: Gonçalo R Abecasis; David Altshuler; Adam Auton; Lisa D Brooks; Richard M Durbin; Richard A Gibbs; Matt E Hurles; Gil A McVean
Journal: Nature Date: 2010-10-28 Impact factor: 49.962

5. Detection of sharing by descent, long-range phasing and haplotype imputation.

Authors: Augustine Kong; Gisli Masson; Michael L Frigge; Arnaldur Gylfason; Pasha Zusmanovich; Gudmar Thorleifsson; Pall I Olason; Andres Ingason; Stacy Steinberg; Thorunn Rafnar; Patrick Sulem; Magali Mouy; Frosti Jonsson; Unnur Thorsteinsdottir; Daniel F Gudbjartsson; Hreinn Stefansson; Kari Stefansson
Journal: Nat Genet Date: 2008-09 Impact factor: 38.330

5 in total

33 in total

Review 1. Between candidate genes and whole genomes: time for alternative approaches in blood pressure genetics.

Authors: Jacob Basson; Jeannette Simino; D C Rao
Journal: Curr Hypertens Rep Date: 2012-02 Impact factor: 5.369

2. Next generation analytic tools for large scale genetic epidemiology studies of complex diseases.

Authors: Leah E Mechanic; Huann-Sheng Chen; Christopher I Amos; Nilanjan Chatterjee; Nancy J Cox; Rao L Divi; Ruzong Fan; Emily L Harris; Kevin Jacobs; Peter Kraft; Suzanne M Leal; Kimberly McAllister; Jason H Moore; Dina N Paltoo; Michael A Province; Erin M Ramos; Marylyn D Ritchie; Kathryn Roeder; Daniel J Schaid; Matthew Stephens; Duncan C Thomas; Clarice R Weinberg; John S Witte; Shunpu Zhang; Sebastian Zöllner; Eric J Feuer; Elizabeth M Gillanders
Journal: Genet Epidemiol Date: 2011-12-06 Impact factor: 2.135

Review 3. Suppression Subtractive Hybridization Versus Next-Generation Sequencing in Plant Genetic Engineering: Challenges and Perspectives.

Authors: Mahbod Sahebi; Mohamed M Hanafi; Parisa Azizi; Abdul Hakim; Sadegh Ashkani; Rambod Abiri
Journal: Mol Biotechnol Date: 2015-10 Impact factor: 2.695

Review 4. Unraveling genetic origin of aging-related traits: evolving concepts.

Authors: Alexander M Kulminski
Journal: Rejuvenation Res Date: 2013-08 Impact factor: 4.663

5. A large-scale screen for coding variants predisposing to psoriasis.

Authors: Huayang Tang; Xin Jin; Yang Li; Hui Jiang; Xianfa Tang; Xu Yang; Hui Cheng; Ying Qiu; Gang Chen; Junpu Mei; Fusheng Zhou; Renhua Wu; Xianbo Zuo; Yong Zhang; Xiaodong Zheng; Qi Cai; Xianyong Yin; Cheng Quan; Haojing Shao; Yong Cui; Fangzhen Tian; Xia Zhao; Hong Liu; Fengli Xiao; Fengping Xu; Jianwen Han; Dongmei Shi; Anping Zhang; Cheng Zhou; Qibin Li; Xing Fan; Liya Lin; Hongqing Tian; Zaixing Wang; Huiling Fu; Fang Wang; Baoqi Yang; Shaowei Huang; Bo Liang; Xuefeng Xie; Yunqing Ren; Qingquan Gu; Guangdong Wen; Yulin Sun; Xueli Wu; Lin Dang; Min Xia; Junjun Shan; Tianhang Li; Lin Yang; Xiuyun Zhang; Yuzhen Li; Chundi He; Aie Xu; Liping Wei; Xiaohang Zhao; Xinghua Gao; Jinhua Xu; Furen Zhang; Jianzhong Zhang; Yingrui Li; Liangdan Sun; Jianjun Liu; Runsheng Chen; Sen Yang; Jun Wang; Xuejun Zhang
Journal: Nat Genet Date: 2013-11-10 Impact factor: 38.330

6. A study of Kibbutzim in Israel reveals risk factors for cardiometabolic traits and subtle population structure.

Authors: Einat Granot-Hershkovitz; David Karasik; Yechiel Friedlander; Laura Rodriguez-Murillo; Rajkumar Dorajoo; Jianjun Liu; Anshuman Sewda; Inga Peter; Shai Carmi; Hagit Hochner
Journal: Eur J Hum Genet Date: 2018-08-14 Impact factor: 4.246

7. Inference of identity by descent in population isolates and optimal sequencing studies.

Authors: Dominik Glodzik; Pau Navarro; Veronique Vitart; Caroline Hayward; Ruth McQuillan; Sarah H Wild; Malcolm G Dunlop; Igor Rudan; Harry Campbell; Chris Haley; Alan F Wright; James F Wilson; Paul McKeigue
Journal: Eur J Hum Genet Date: 2013-01-30 Impact factor: 4.246