Literature DB >> 11252747

Use of population isolates for mapping complex traits.

L Peltonen1, A Palotie, K Lange.   

Abstract

Geneticists have repeatedly turned to population isolates for mapping and cloning Mendelian disease genes. Population isolates possess many advantages in this regard. Foremost among these is the tendency for affected individuals to share ancestral haplotypes derived from a handful of founders. These haplotype signatures have guided scientists in the fine mapping of scores of rare disease genes. The past successes with Mendelian disorders using population isolates have prompted unprecedented interest among medical researchers in both the public and private sectors. Despite the obvious genetic and environmental complications, geneticists have targeted several population isolates for mapping genes for complex diseases.

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Year:  2000        PMID： 11252747     DOI： 10.1038/35042049

Source DB:  PubMed          Journal:  Nat Rev Genet        ISSN： 1471-0056            Impact factor:   53.242


  142 in total

1.  Extensive linkage disequilibrium in small human populations in Eurasia.

Authors:  Henrik Kaessmann; Sebastian Zöllner; Anna C Gustafsson; Victor Wiebe; Maris Laan; Joakim Lundeberg; Mathias Uhlén; Svante Pääbo
Journal:  Am J Hum Genet       Date:  2002-01-28       Impact factor: 11.025

2.  Susceptibility loci for preeclampsia on chromosomes 2p25 and 9p13 in Finnish families.

Authors:  Hannele Laivuori; Päivi Lahermo; Vesa Ollikainen; Elisabeth Widen; Leena Häivä-Mällinen; Helena Sundström; Tarja Laitinen; Risto Kaaja; Olavi Ylikorkala; Juha Kere
Journal:  Am J Hum Genet       Date:  2002-12-09       Impact factor: 11.025

3.  Targeted sequencing of NOTCH signaling pathway genes and association analysis of variants correlated with mandibular prognathism.

Authors:  Xianzhuo Han; Xueyan Xiong; Xiujuan Shi; Fengshan Chen; Yongming Li
Journal:  Head Face Med       Date:  2021-05-26       Impact factor: 2.151

4.  Genomewide linkage disequilibrium mapping of severe bipolar disorder in a population isolate.

Authors:  Roel A Ophoff; Michael A Escamilla; Susan K Service; Mitzi Spesny; Dar B Meshi; Wingman Poon; Julio Molina; Eduardo Fournier; Alvaro Gallegos; Carol Mathews; Thomas Neylan; Steven L Batki; Erin Roche; Margarita Ramirez; Sandra Silva; Melissa C De Mille; Penny Dong; Pedro E Leon; Victor I Reus; Lodewijk A Sandkuijl; Nelson B Freimer
Journal:  Am J Hum Genet       Date:  2002-07-15       Impact factor: 11.025

5.  Testing for population subdivision and association in four case-control studies.

Authors:  Kristin G Ardlie; Kathryn L Lunetta; Mark Seielstad
Journal:  Am J Hum Genet       Date:  2002-07-02       Impact factor: 11.025

6.  Minimum description length block finder, a method to identify haplotype blocks and to compare the strength of block boundaries.

Authors:  H Mannila; M Koivisto; M Perola; T Varilo; W Hennah; J Ekelund; M Lukk; L Peltonen; E Ukkonen
Journal:  Am J Hum Genet       Date:  2003-05-20       Impact factor: 11.025

7.  Combined analysis of genome scans of dutch and finnish families reveals a susceptibility locus for high-density lipoprotein cholesterol on chromosome 16q.

Authors:  Päivi Pajukanta; Hooman Allayee; Kelly L Krass; Ali Kuraishy; Aino Soro; Heidi E Lilja; Rebecca Mar; Marja-Riitta Taskinen; Ilpo Nuotio; Markku Laakso; Jerome I Rotter; Tjerk W A de Bruin; Rita M Cantor; Aldons J Lusis; Leena Peltonen
Journal:  Am J Hum Genet       Date:  2003-03-12       Impact factor: 11.025

8.  Genomewide linkage scan for schizophrenia susceptibility loci among Ashkenazi Jewish families shows evidence of linkage on chromosome 10q22.

Authors:  M Daniele Fallin; Virginia K Lasseter; Paula S Wolyniec; John A McGrath; Gerald Nestadt; David Valle; Kung-Yee Liang; Ann E Pulver
Journal:  Am J Hum Genet       Date:  2003-08-15       Impact factor: 11.025

9.  Striking differentiation of sub-populations within a genetically homogeneous isolate (Ogliastra) in Sardinia as revealed by mtDNA analysis.

Authors:  Cristina Fraumene; Enrico Petretto; Andrea Angius; Mario Pirastu
Journal:  Hum Genet       Date:  2003-09-16       Impact factor: 4.132

10.  Susceptibility loci for adiposity phenotypes on 8p, 9p, and 16q in American Samoa and Samoa.

Authors:  Karolina Aberg; Feng Dai; Guangyun Sun; Ember D Keighley; Subba R Indugula; Sarah T Roberts; Qi Zhang; Diane Smelser; Satupaitea Viali; John Tuitele; Li Jin; Ranjan Deka; Daniel E Weeks; Stephen T McGarvey
Journal:  Obesity (Silver Spring)       Date:  2008-12-18       Impact factor: 5.002
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