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Literature DB >> 21444075

Type 2 diabetes susceptibility single-nucleotide polymorphisms are not associated with polycystic ovary syndrome.

Kathryn G Ewens¹, Michelle R Jones, Wendy Ankener, Douglas R Stewart, Margrit Urbanek, Andrea Dunaif, Richard S Legro, Angela Chua, Ricardo Azziz, Richard S Spielman, Mark O Goodarzi, Jerome F Strauss.

Abstract

Two cohorts of women with polycystic ovary syndrome (PCOS), comprising 400 probands and affected sisters in 365 families and a case-control group including 395 women with PCOS and 171 healthy women with regular menstrual cycles, were studied to determine whether single-nucleotide polymorphisms (SNPs) identified as susceptibility loci in genomewide association studies of type 2 diabetes are also associated with PCOS. None of the 18 allelic variants in 10 genes previously shown to be associated with type 2 diabetes were found to be associated with PCOS, but some were associated with indices of beta cell function.

Entities: Chemical Disease Gene Mutation Species

Mesh：

Year: 2011 PMID： 21444075 PMCID： PMC3124609 DOI： 10.1016/j.fertnstert.2011.02.050

Source DB: PubMed Journal: Fertil Steril ISSN： 0015-0282 Impact factor: 7.329

28 in total

1. Genetic Power Calculator: design of linkage and association genetic mapping studies of complex traits.

Authors: S Purcell; S S Cherny; P C Sham
Journal: Bioinformatics Date: 2003-01 Impact factor: 6.937

Review 2. Insulin resistance in polycystic ovary syndrome: progress and paradoxes.

Authors: A M Venkatesan; A Dunaif; A Corbould
Journal: Recent Prog Horm Res Date: 2001

3. Association studies of genetic variation in the WFS1 gene and type 2 diabetes in U.K. populations.

Authors: Jayne A L Minton; Andrew T Hattersley; Katharine Owen; Mark I McCarthy; Mark Walker; Farida Latif; Timothy Barrett; Timothy M Frayling
Journal: Diabetes Date: 2002-04 Impact factor: 9.461

4. The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes.

Authors: D Altshuler; J N Hirschhorn; M Klannemark; C M Lindgren; M C Vohl; J Nemesh; C R Lane; S F Schaffner; S Bolk; C Brewer; T Tuomi; D Gaudet; T J Hudson; M Daly; L Groop; E S Lander
Journal: Nat Genet Date: 2000-09 Impact factor: 38.330

5. Heritability of insulin secretion and insulin action in women with polycystic ovary syndrome and their first degree relatives.

Authors: S Colilla; N J Cox; D A Ehrmann
Journal: J Clin Endocrinol Metab Date: 2001-05 Impact factor: 5.958

6. Genetic contributions to glucose intolerance in polycystic ovary syndrome.

Authors: David A Ehrmann
Journal: Reprod Biomed Online Date: 2004-07 Impact factor: 3.828

Review 7. Type 2 diabetes and the polycystic ovary syndrome.

Authors: B Pelusi; A Gambineri; R Pasquali
Journal: Minerva Ginecol Date: 2004-02

8. Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia.

Authors: Johan Rung; Stéphane Cauchi; Anders Albrechtsen; Lishuang Shen; Ghislain Rocheleau; Christine Cavalcanti-Proença; François Bacot; Beverley Balkau; Alexandre Belisle; Knut Borch-Johnsen; Guillaume Charpentier; Christian Dina; Emmanuelle Durand; Paul Elliott; Samy Hadjadj; Marjo-Riitta Järvelin; Jaana Laitinen; Torsten Lauritzen; Michel Marre; Alexander Mazur; David Meyre; Alexandre Montpetit; Charlotta Pisinger; Barry Posner; Pernille Poulsen; Anneli Pouta; Marc Prentki; Rasmus Ribel-Madsen; Aimo Ruokonen; Anelli Sandbaek; David Serre; Jean Tichet; Martine Vaxillaire; Jørgen F P Wojtaszewski; Allan Vaag; Torben Hansen; Constantin Polychronakos; Oluf Pedersen; Philippe Froguel; Robert Sladek
Journal: Nat Genet Date: 2009-09-06 Impact factor: 38.330

9. The prevalence and features of the polycystic ovary syndrome in an unselected population.

Authors: Ricardo Azziz; Keslie S Woods; Rosario Reyna; Timothy J Key; Eric S Knochenhauer; Bulent O Yildiz
Journal: J Clin Endocrinol Metab Date: 2004-06 Impact factor: 5.958

10. Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM).

Authors: R S Spielman; R E McGinnis; W J Ewens
Journal: Am J Hum Genet Date: 1993-03 Impact factor: 11.025

12 in total

1. Genetic variations in SREBP-1 and LXRα are not directly associated to PCOS but contribute to the physiological specifics of the syndrome.

Authors: Birgit Knebel; Onno E Janssen; Susanne Hahn; Sylvia Jacob; Ulrike Nitzgen; Jutta Haas; Dirk Muller-Wieland; Jorg Kotzka
Journal: Mol Biol Rep Date: 2012-02-04 Impact factor: 2.316

2. Perspectives in Polycystic Ovary Syndrome: From Hair to Eternity.

Authors: Andrea Dunaif
Journal: J Clin Endocrinol Metab Date: 2016-02-23 Impact factor: 5.958

3. Polycystic ovary syndrome is not associated with genetic variants that mark risk of type 2 diabetes.

Authors: R Saxena; C K Welt
Journal: Acta Diabetol Date: 2012-03-03 Impact factor: 4.280

Review 4. Genetics of polycystic ovary syndrome.

Authors: Corrine K Welt; Jessica M Duran
Journal: Semin Reprod Med Date: 2014-04-08 Impact factor: 1.303

Review 5. Association between rs7903146 and rs12255372 polymorphisms of transcription factor 7-like 2 gene and polycystic ovary syndrome: a systematic review and meta-analysis.

Authors: Ramon Bossardi Ramos; Vitor Costa Fabris; Letícia de Almeida Brondani; Poli Mara Spritzer
Journal: Endocrine Date: 2015-02-13 Impact factor: 3.633