Literature DB >> 21441921

Aβ(1-42) inhibition of LTP is mediated by a signaling pathway involving caspase-3, Akt1 and GSK-3β.

Jihoon Jo1, Daniel J Whitcomb, Kimberly Moore Olsen, Talitha L Kerrigan, Shih-Ching Lo, Gilles Bru-Mercier, Bryony Dickinson, Sarah Scullion, Morgan Sheng, Graham Collingridge, Kwangwook Cho.   

Abstract

Amyloid-β(1-42) (Aβ) is thought to be a major mediator of the cognitive deficits in Alzheimer's disease. The ability of Aβ to inhibit hippocampal long-term potentiation provides a cellular correlate of this action, but the underlying molecular mechanism is only partially understood. We found that a signaling pathway involving caspase-3, Akt1 and glycogen synthase kinase-3β is an important mediator of this effect in rats and mice.

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Year:  2011        PMID： 21441921     DOI： 10.1038/nn.2785

Source DB:  PubMed          Journal:  Nat Neurosci        ISSN： 1097-6256            Impact factor:   24.884


  15 in total

Review 1.  Amyloid-beta-induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks.

Authors:  Jorge J Palop; Lennart Mucke
Journal:  Nat Neurosci       Date:  2010-07       Impact factor: 24.884

2.  Multiple caspases are involved in beta-amyloid-induced neuronal apoptosis.

Authors:  J W Allen; B A Eldadah; X Huang; S M Knoblach; A I Faden
Journal:  J Neurosci Res       Date:  2001-07-01       Impact factor: 4.164

3.  ERK1/2 activation mediates Abeta oligomer-induced neurotoxicity via caspase-3 activation and tau cleavage in rat organotypic hippocampal slice cultures.

Authors:  Young Hae Chong; Yoo Jeong Shin; Eun Ok Lee; Rakez Kayed; Charles G Glabe; Andrea J Tenner
Journal:  J Biol Chem       Date:  2006-05-18       Impact factor: 5.157

4.  Glycogen synthase kinase 3 beta induces caspase-cleaved tau aggregation in situ.

Authors:  Jae-Hyeon Cho; Gail V W Johnson
Journal:  J Biol Chem       Date:  2004-10-19       Impact factor: 5.157

5.  Block of long-term potentiation by naturally secreted and synthetic amyloid beta-peptide in hippocampal slices is mediated via activation of the kinases c-Jun N-terminal kinase, cyclin-dependent kinase 5, and p38 mitogen-activated protein kinase as well as metabotropic glutamate receptor type 5.

Authors:  Qinwen Wang; Dominic M Walsh; Michael J Rowan; Dennis J Selkoe; Roger Anwyl
Journal:  J Neurosci       Date:  2004-03-31       Impact factor: 6.167

6.  GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides.

Authors:  Christopher J Phiel; Christina A Wilson; Virginia M-Y Lee; Peter S Klein
Journal:  Nature       Date:  2003-05-22       Impact factor: 49.962

7.  Soluble oligomers of amyloid Beta protein facilitate hippocampal long-term depression by disrupting neuronal glutamate uptake.

Authors:  Shaomin Li; Soyon Hong; Nina E Shepardson; Dominic M Walsh; Ganesh M Shankar; Dennis Selkoe
Journal:  Neuron       Date:  2009-06-25       Impact factor: 17.173

8.  Caspase-3 activation via mitochondria is required for long-term depression and AMPA receptor internalization.

Authors:  Zheng Li; Jihoon Jo; Jie-Min Jia; Shih-Ching Lo; Daniel J Whitcomb; Song Jiao; Kwangwook Cho; Morgan Sheng
Journal:  Cell       Date:  2010-05-28       Impact factor: 41.582

9.  LTP inhibits LTD in the hippocampus via regulation of GSK3beta.

Authors:  Stéphane Peineau; Changiz Taghibiglou; Clarrisa Bradley; Tak Pan Wong; Lidong Liu; Jie Lu; Edmond Lo; Dongchuan Wu; Emilia Saule; Tristan Bouschet; Paul Matthews; John T R Isaac; Zuner A Bortolotto; Yu Tian Wang; Graham L Collingridge
Journal:  Neuron       Date:  2007-03-01       Impact factor: 17.173

10.  The selectivity of protein kinase inhibitors: a further update.

Authors:  Jenny Bain; Lorna Plater; Matt Elliott; Natalia Shpiro; C James Hastie; Hilary McLauchlan; Iva Klevernic; J Simon C Arthur; Dario R Alessi; Philip Cohen
Journal:  Biochem J       Date:  2007-12-15       Impact factor: 3.857
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  138 in total

1.  Combination therapy targeting Akt and mammalian target of rapamycin improves functional outcome after controlled cortical impact in mice.

Authors:  Juyeon Park; Jimmy Zhang; Jianhua Qiu; Xiaoxia Zhu; Alexei Degterev; Eng H Lo; Michael J Whalen
Journal:  J Cereb Blood Flow Metab       Date:  2011-09-21       Impact factor: 6.200

Review 2.  NMDA receptors and metaplasticity: mechanisms and possible roles in neuropsychiatric disorders.

Authors:  Charles F Zorumski; Yukitoshi Izumi
Journal:  Neurosci Biobehav Rev       Date:  2012-01-02       Impact factor: 8.989

Review 3.  Synapses and Alzheimer's disease.

Authors:  Morgan Sheng; Bernardo L Sabatini; Thomas C Südhof
Journal:  Cold Spring Harb Perspect Biol       Date:  2012-05-01       Impact factor: 10.005

Review 4.  New developments on the role of NMDA receptors in Alzheimer's disease.

Authors:  Roberto Malinow
Journal:  Curr Opin Neurobiol       Date:  2011-09-29       Impact factor: 6.627

Review 5.  Driving apoptosis-relevant proteins toward neural differentiation.

Authors:  Susana Solá; Márcia M Aranha; Cecília M P Rodrigues
Journal:  Mol Neurobiol       Date:  2012-07-01       Impact factor: 5.590

6.  PTEN recruitment controls synaptic and cognitive function in Alzheimer's models.

Authors:  Shira Knafo; Cristina Sánchez-Puelles; Ernest Palomer; Igotz Delgado; Jonathan E Draffin; Janire Mingo; Tina Wahle; Kanwardeep Kaleka; Liping Mou; Inmaculada Pereda-Perez; Edvin Klosi; Erik B Faber; Heidi M Chapman; Laura Lozano-Montes; Ana Ortega-Molina; Lara Ordóñez-Gutiérrez; Francisco Wandosell; Jose Viña; Carlos G Dotti; Randy A Hall; Rafael Pulido; Nashaat Z Gerges; Andrew M Chan; Mark R Spaller; Manuel Serrano; César Venero; José A Esteban
Journal:  Nat Neurosci       Date:  2016-01-18       Impact factor: 24.884

Review 7.  Mitochondrial dysfunction and cell death in neurodegenerative diseases through nitroxidative stress.

Authors:  Mohammed Akbar; Musthafa Mohamed Essa; Ghazi Daradkeh; Mohamed A Abdelmegeed; Youngshim Choi; Lubna Mahmood; Byoung-Joon Song
Journal:  Brain Res       Date:  2016-02-13       Impact factor: 3.252

8.  Activated caspase detection in living tissue combined with subsequent retrograde labeling, immunohistochemistry or in situ hybridization in whole-mounted lamprey brains.

Authors:  Jianli Hu; Guixin Zhang; Michael E Selzer
Journal:  J Neurosci Methods       Date:  2013-09-08       Impact factor: 2.390

9.  Glucagon-like peptide-1 cleavage product GLP-1(9-36) amide rescues synaptic plasticity and memory deficits in Alzheimer's disease model mice.

Authors:  Tao Ma; Xueliang Du; Joseph E Pick; Guangzhi Sui; Michael Brownlee; Eric Klann
Journal:  J Neurosci       Date:  2012-10-03       Impact factor: 6.167

Review 10.  "Boomerang Neuropathology" of Late-Onset Alzheimer's Disease is Shrouded in Harmful "BDDS": Breathing, Diet, Drinking, and Sleep During Aging.

Authors:  Mak Adam Daulatzai
Journal:  Neurotox Res       Date:  2015-04-25       Impact factor: 3.911
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