Literature DB >> 21962484

New developments on the role of NMDA receptors in Alzheimer's disease.

Roberto Malinow1.   

Abstract

Since the initial findings that NMDA receptors play important roles in cellular models of learning as well as neurotoxicity, abnormal function of this receptor has been considered a potential mechanism in the pathophysiology underlying Alzheimer's disease. Treatment of Alzheimer's disease with an NMDA receptor antagonist began several years ago, with some limited success. More recent mechanistic studies have examined the role of NMDA receptors in the synaptic effects of beta amyloid (Aβ).
Copyright © 2011 Elsevier Ltd. All rights reserved.

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Year:  2011        PMID： 21962484      PMCID： PMC3405538          DOI： 10.1016/j.conb.2011.09.001

Source DB:  PubMed          Journal:  Curr Opin Neurobiol        ISSN： 0959-4388            Impact factor:   6.627


  52 in total

Review 1.  Nicotinic acetylcholine receptor interaction with beta-amyloid: molecular, cellular, and physiological consequences.

Authors:  R H Parri; T K Dineley
Journal:  Curr Alzheimer Res       Date:  2010-02       Impact factor: 3.498

2.  Early neuronal dysfunction by amyloid β oligomers depends on activation of NR2B-containing NMDA receptors.

Authors:  Raik Rönicke; Marina Mikhaylova; Sabine Rönicke; Jessica Meinhardt; Ulrich H Schröder; Marcus Fändrich; Georg Reiser; Michael R Kreutz; Klaus G Reymann
Journal:  Neurobiol Aging       Date:  2010-02-04       Impact factor: 4.673

3.  Many neuronal and behavioral impairments in transgenic mouse models of Alzheimer's disease are independent of caspase cleavage of the amyloid precursor protein.

Authors:  Julie A Harris; Nino Devidze; Brian Halabisky; Iris Lo; Myo T Thwin; Gui-Qiu Yu; Dale E Bredesen; Eliezer Masliah; Lennart Mucke
Journal:  J Neurosci       Date:  2010-01-06       Impact factor: 6.167

Review 4.  Signaling of the neurotrophin receptor p75 in relation to Alzheimer's disease.

Authors:  Adama Diarra; Thangiah Geetha; Pamella Potter; Jeganathan Ramesh Babu
Journal:  Biochem Biophys Res Commun       Date:  2009-10-07       Impact factor: 3.575

5.  Rapid, concurrent alterations in pre- and postsynaptic structure induced by naturally-secreted amyloid-beta protein.

Authors:  Barbara Calabrese; Gideon M Shaked; Iustin V Tabarean; Julia Braga; Edward H Koo; Shelley Halpain
Journal:  Mol Cell Neurosci       Date:  2007-02-12       Impact factor: 4.314

6.  GluN2B subunit-containing NMDA receptor antagonists prevent Abeta-mediated synaptic plasticity disruption in vivo.

Authors:  Neng-Wei Hu; Igor Klyubin; Roger Anwyl; Roger Anwy; Michael J Rowan
Journal:  Proc Natl Acad Sci U S A       Date:  2009-11-16       Impact factor: 11.205

7.  Soluble oligomers of amyloid Beta protein facilitate hippocampal long-term depression by disrupting neuronal glutamate uptake.

Authors:  Shaomin Li; Soyon Hong; Nina E Shepardson; Dominic M Walsh; Ganesh M Shankar; Dennis Selkoe
Journal:  Neuron       Date:  2009-06-25       Impact factor: 17.173

8.  Amyloid beta from axons and dendrites reduces local spine number and plasticity.

Authors:  Wei Wei; Louis N Nguyen; Helmut W Kessels; Hiroaki Hagiwara; Sangram Sisodia; Roberto Malinow
Journal:  Nat Neurosci       Date:  2009-12-27       Impact factor: 24.884

9.  Caspase-3 activation via mitochondria is required for long-term depression and AMPA receptor internalization.

Authors:  Zheng Li; Jihoon Jo; Jie-Min Jia; Shih-Ching Lo; Daniel J Whitcomb; Song Jiao; Kwangwook Cho; Morgan Sheng
Journal:  Cell       Date:  2010-05-28       Impact factor: 41.582

10.  Cellular prion protein mediates impairment of synaptic plasticity by amyloid-beta oligomers.

Authors:  Juha Laurén; David A Gimbel; Haakon B Nygaard; John W Gilbert; Stephen M Strittmatter
Journal:  Nature       Date:  2009-02-26       Impact factor: 49.962
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  44 in total

1.  Glycolytic flux controls D-serine synthesis through glyceraldehyde-3-phosphate dehydrogenase in astrocytes.

Authors:  Masataka Suzuki; Jumpei Sasabe; Yurika Miyoshi; Kanako Kuwasako; Yutaka Muto; Kenji Hamase; Masaaki Matsuoka; Nobuaki Imanishi; Sadakazu Aiso
Journal:  Proc Natl Acad Sci U S A       Date:  2015-04-13       Impact factor: 11.205

2.  Hippocampal Mossy Fibers Synapses in CA3 Pyramidal Cells Are Altered at an Early Stage in a Mouse Model of Alzheimer's Disease.

Authors:  Silvia Viana da Silva; Pei Zhang; Matthias Georg Haberl; Virginie Labrousse; Noëlle Grosjean; Christophe Blanchet; Andreas Frick; Christophe Mulle
Journal:  J Neurosci       Date:  2019-03-18       Impact factor: 6.167

3.  Posttranslational modification impact on the mechanism by which amyloid-β induces synaptic dysfunction.

Authors:  Katarzyna M Grochowska; PingAn Yuanxiang; Julia Bär; Rajeev Raman; Gemma Brugal; Giriraj Sahu; Michaela Schweizer; Arthur Bikbaev; Stephan Schilling; Hans-Ulrich Demuth; Michael R Kreutz
Journal:  EMBO Rep       Date:  2017-04-18       Impact factor: 8.807

Review 4.  NMDA receptor subunit diversity: impact on receptor properties, synaptic plasticity and disease.

Authors:  Pierre Paoletti; Camilla Bellone; Qiang Zhou
Journal:  Nat Rev Neurosci       Date:  2013-06       Impact factor: 34.870

5.  Hydrogen sulfide induced disruption of Na+ homeostasis in the cortex.

Authors:  Dongman Chao; Xiaozhou He; Yilin Yang; Gianfranco Balboni; Severo Salvadori; Dong H Kim; Ying Xia
Journal:  Toxicol Sci       Date:  2012-04-02       Impact factor: 4.849

6.  Impairments in experience-dependent scaling and stability of hippocampal place fields limit spatial learning in a mouse model of Alzheimer's disease.

Authors:  Rong Zhao; Stephanie W Fowler; Angie C A Chiang; Daoyun Ji; Joanna L Jankowsky
Journal:  Hippocampus       Date:  2014-05-05       Impact factor: 3.899

7.  Cooperative Dynamics of Intact AMPA and NMDA Glutamate Receptors: Similarities and Subfamily-Specific Differences.

Authors:  Anindita Dutta; James Krieger; Ji Young Lee; Javier Garcia-Nafria; Ingo H Greger; Ivet Bahar
Journal:  Structure       Date:  2015-08-06       Impact factor: 5.006

8.  Isotope-edited FTIR reveals distinct aggregation and structural behaviors of unmodified and pyroglutamylated amyloid β peptides.

Authors:  Greg Goldblatt; Jason O Matos; Jeremy Gornto; Suren A Tatulian
Journal:  Phys Chem Chem Phys       Date:  2015-12-28       Impact factor: 3.676

9.  Evidence for Alzheimer's disease-linked synapse loss and compensation in mouse and human hippocampal CA1 pyramidal neurons.

Authors:  Krystina M Neuman; Elizabeth Molina-Campos; Timothy F Musial; Andrea L Price; Kwang-Jin Oh; Malerie L Wolke; Eric W Buss; Stephen W Scheff; Elliott J Mufson; Daniel A Nicholson
Journal:  Brain Struct Funct       Date:  2014-07-17       Impact factor: 3.270

Review 10.  Vascular mTOR-dependent mechanisms linking the control of aging to Alzheimer's disease.

Authors:  Veronica Galvan; Matthew J Hart
Journal:  Biochim Biophys Acta       Date:  2015-11-27
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