| Literature DB >> 2144188 |
B P Rosen1, C M Hsu, C E Karkaria, P Kaur, J B Owolabi, L S Tisa.
Abstract
An anion-translocating ATPase has been identified as the product of the arsenical resistance operon of resistance plasmid R773. When expressed in Escherichia coli this ATP-driven oxyanion pump catalyzes extrusion of the oxyanions arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces resistance to the toxic agents. The pump is composed of two polypeptides, the products of the arsA and arsB genes. This two-subunit enzyme produces resistance to arsenite and antimonite. A third gene, arsC, expands the substrate specificity to allow for arsenate pumping and resistance.Entities:
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Year: 1990 PMID： 2144188 DOI： 10.1016/0005-2728(90)90249-4
Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002