OBJECTIVE: To investigate the human primary motor cortex (M1) excitability changes induced by momentary reward. METHODS: To test the changes in excitatory and inhibitory functions of M1, motor-evoked potentials (MEPs), short-interval intracortical inhibition (SICI) and short-latency afferent inhibition (SAI) were tested in the abductor pollicis brevis (APB) muscle of non-dominant hand in 14 healthy volunteers by transcranial magnetic stimulation (TMS) during a behavioral task in which subjects were pseudorandomly received either reward target or non-target stimuli in response to a cue. To control sensorimotor and attention effects, a sensorimotor control task was done replacing the reward target with non-reward target. RESULTS: The SICI was increased, and the SAI was decreased significantly during the presentation of the reward target stimuli. Those changes were not evident during non-reward target stimuli in the sensorimotor control task, indicating that this change is specific to momentary reward. CONCLUSIONS: Momentary rewarding is associated with change in intracortical inhibitory circuits of M1. SIGNIFICANCE: TMS may be a useful probe to study the reward system in health and in many diseases in which its dysfunction is suspected.
OBJECTIVE: To investigate the human primary motor cortex (M1) excitability changes induced by momentary reward. METHODS: To test the changes in excitatory and inhibitory functions of M1, motor-evoked potentials (MEPs), short-interval intracortical inhibition (SICI) and short-latency afferent inhibition (SAI) were tested in the abductor pollicis brevis (APB) muscle of non-dominant hand in 14 healthy volunteers by transcranial magnetic stimulation (TMS) during a behavioral task in which subjects were pseudorandomly received either reward target or non-target stimuli in response to a cue. To control sensorimotor and attention effects, a sensorimotor control task was done replacing the reward target with non-reward target. RESULTS: The SICI was increased, and the SAI was decreased significantly during the presentation of the reward target stimuli. Those changes were not evident during non-reward target stimuli in the sensorimotor control task, indicating that this change is specific to momentary reward. CONCLUSIONS: Momentary rewarding is associated with change in intracortical inhibitory circuits of M1. SIGNIFICANCE: TMS may be a useful probe to study the reward system in health and in many diseases in which its dysfunction is suspected.
Authors: Marc R Kamke; Michelle G Hall; Hayley F Lye; Martin V Sale; Laura R Fenlon; Timothy J Carroll; Stephan Riek; Jason B Mattingley Journal: J Neurosci Date: 2012-05-16 Impact factor: 6.167
Authors: Eric Mooshagian; Aysha Keisler; Trelawny Zimmermann; Janell M Schweickert; Eric M Wassermann Journal: Neuropsychologia Date: 2014-12-24 Impact factor: 3.139
Authors: Donald L Gilbert; David A Huddleston; Steve W Wu; Ernest V Pedapati; Paul S Horn; Kathryn Hirabayashi; Deanna Crocetti; Eric M Wassermann; Stewart H Mostofsky Journal: Neurology Date: 2019-07-17 Impact factor: 9.910