| Literature DB >> 21439689 |
Marijana Hranjec1, Kristina Starčević, Sandra Kraljević Pavelić, Pero Lučin, Krešimir Pavelić, Grace Karminski Zamola.
Abstract
A series of novel benzimidazole substituted Schiff bases were synthesized by reaction of aromatic aldehydes with corresponding 2-aminobenzimidazoles. Their structure has been studied by 1H and 13C NMR, IR and UV/Vis spectroscopy. Majority of prepared Schiff bases were tested on their antiproliferative activity in vitro and exerted non-specific antiproliferative activity on the tested cell lines at the highest tested concentration. Compounds 18 and 19 exerted the strongest non-specific antiproliferative effect on all cell lines and a concentration-dependent effect on HeLa and MCF-7 cell lines at micromolar concentrations but simultaneously being highly cytotoxic on human fibroblasts as well.Entities:
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Year: 2011 PMID： 21439689 DOI： 10.1016/j.ejmech.2011.03.008
Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514