OBJECTIVE: The aim of this study was to evaluate fetal hemoglobin (HbF) and α(1)-microglobulin (A1M) in maternal serum as first-trimester biomarkers for preeclampsia (PE). STUDY DESIGN: The design was a case-control study. We included 96 patients in the first trimester of pregnancy (60 with PE and 36 controls). Venous serum samples were analyzed for HbF and total hemoglobin (Hb) by enzyme-linked immunosorbent assay and for A1M by radioimmunoassay. Sensitivity and specificity was calculated by logistic regression and receiver operating characteristic curve analysis. RESULTS: The HbF/Hb ratio and A1M concentration were significantly elevated in serum from women with subsequent development of PE (P < .0001). The optimal sensitivity and specificity was obtained using the biomarkers in combination; 69% sensitivity for a 5% screen positive rate and 90% sensitivity for a 23% screen positive rate. CONCLUSION: The study suggests that HbF/Hb ratio in combination with A1M is predictive biomarkers for PE.
OBJECTIVE: The aim of this study was to evaluate fetal hemoglobin (HbF) and α(1)-microglobulin (A1M) in maternal serum as first-trimester biomarkers for preeclampsia (PE). STUDY DESIGN: The design was a case-control study. We included 96 patients in the first trimester of pregnancy (60 with PE and 36 controls). Venous serum samples were analyzed for HbF and total hemoglobin (Hb) by enzyme-linked immunosorbent assay and for A1M by radioimmunoassay. Sensitivity and specificity was calculated by logistic regression and receiver operating characteristic curve analysis. RESULTS: The HbF/Hb ratio and A1M concentration were significantly elevated in serum from women with subsequent development of PE (P < .0001). The optimal sensitivity and specificity was obtained using the biomarkers in combination; 69% sensitivity for a 5% screen positive rate and 90% sensitivity for a 23% screen positive rate. CONCLUSION: The study suggests that HbF/Hb ratio in combination with A1M is predictive biomarkers for PE.
Authors: Sarwat I Gilani; Ulrik Dolberg Anderson; Muthuvel Jayachandran; Tracey L Weissgerber; Ladan Zand; Wendy M White; Natasa Milic; Maria Lourdes Gonzalez Suarez; Rangit Reddy Vallapureddy; Åsa Nääv; Lena Erlandsson; John C Lieske; Joseph P Grande; Karl A Nath; Stefan R Hansson; Vesna D Garovic Journal: J Am Soc Nephrol Date: 2017-07-20 Impact factor: 10.121
Authors: Yamile Lopez-Hernandez; Jorge Alejandro Saldivar-Nava; Idalia Garza-Veloz; Ivan Delgado-Enciso; Laura Elia Martinez-de-Villarreal; Patricia Yahuaca-Mendoza; Iram Pablo Rodriguez-Sanchez; Laura Lopez-Gilibets; Jorge Issac Galvan-Tejada; Carlos Eric Galvan-Tejada; Jose Maria Celaya-Padilla; Margarita L Martinez-Fierro Journal: Int Urol Nephrol Date: 2016-08-29 Impact factor: 2.370
Authors: Lena Wester-Rosenlöf; Vera Casslén; Josefin Axelsson; Anneli Edström-Hägerwall; Magnus Gram; Madlene Holmqvist; Martin E Johansson; Iréne Larsson; David Ley; Karel Marsal; Matthias Mörgelin; Bengt Rippe; Sigurbjörg Rutardottir; Behnaz Shohani; Bo Akerström; Stefan R Hansson Journal: PLoS One Date: 2014-01-28 Impact factor: 3.240
Authors: Magnus Gram; Ulrik Dolberg Anderson; Maria E Johansson; Anneli Edström-Hägerwall; Irene Larsson; Maya Jälmby; Stefan R Hansson; Bo Åkerström Journal: PLoS One Date: 2015-09-14 Impact factor: 3.240
Authors: Pensée Wu; Caroline van den Berg; Zarko Alfirevic; Shaughn O'Brien; Maria Röthlisberger; Philip Newton Baker; Louise C Kenny; Karolina Kublickiene; Johannes J Duvekot Journal: Int J Mol Sci Date: 2015-09-23 Impact factor: 5.923