Literature DB >> 2143567

Inhibition of neuronal 5-HT uptake by ketamine, but not halothane, involves disruption of substrate recognition by the transporter.

D C Martin1, R P Introna, R S Aronstam.   

Abstract

The effects of halothane and ketamine on (1) serotonin (5-hydroxytryptamine; 5-HT) uptake and (2) paroxetine binding to the 5-HT transporter in neuronal membranes were determined in rat brain. Both anesthetics inhibited the uptake of [3H]5-HT by synaptosomes, but only ketamine affected binding of [3H]paroxetine to the 5-HT transporter. Saturation analysis indicated that ketamine inhibition of [3H]paroxetine binding was competitive (Ki = 18.8 microM). These results indicate that halothane and ketamine inhibit 5-HT transport by different mechanisms.

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Year:  1990        PMID： 2143567     DOI： 10.1016/0304-3940(90)90329-8

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  14 in total

1.  5-HT1A and 5-HT1B receptors differentially modulate rate and timing of auditory responses in the mouse inferior colliculus.

Authors:  Lissandra Castellan Baldan Ramsey; Shiva R Sinha; Laura M Hurley
Journal:  Eur J Neurosci       Date:  2010-07-14       Impact factor: 3.386

Review 2.  Ketamine and Ketamine Metabolite Pharmacology: Insights into Therapeutic Mechanisms.

Authors:  Panos Zanos; Ruin Moaddel; Patrick J Morris; Lace M Riggs; Jaclyn N Highland; Polymnia Georgiou; Edna F R Pereira; Edson X Albuquerque; Craig J Thomas; Carlos A Zarate; Todd D Gould
Journal:  Pharmacol Rev       Date:  2018-07       Impact factor: 25.468

3.  Preclinical toxicological study of prolonged exposure to ketamine as an antidepressant.

Authors:  Julia Zaccarelli-Magalhães; André Rinaldi Fukushima; Natalia Moreira; Marianna Manes; Gabriel Ramos de Abreu; Esther Lopes Ricci; Paula A Faria Waziry; Helenice de Souza Spinosa
Journal:  Pharmacol Rep       Date:  2019-12-20       Impact factor: 3.024

4.  Subanesthetic doses of ketamine transiently decrease serotonin transporter activity: a PET study in conscious monkeys.

Authors:  Shigeyuki Yamamoto; Hiroyuki Ohba; Shingo Nishiyama; Norihiro Harada; Takeharu Kakiuchi; Hideo Tsukada; Edward F Domino
Journal:  Neuropsychopharmacology       Date:  2013-07-24       Impact factor: 7.853

5.  Ketamine potentiates 5-HT3 receptor-mediated currents in rabbit nodose ganglion neurones.

Authors:  J A Peters; H M Malone; J J Lambert
Journal:  Br J Pharmacol       Date:  1991-07       Impact factor: 8.739

Review 6.  Overlap in the neural circuitry and molecular mechanisms underlying ketamine abuse and its use as an antidepressant.

Authors:  Saurabh S Kokane; Ross J Armant; Carlos A Bolaños-Guzmán; Linda I Perrotti
Journal:  Behav Brain Res       Date:  2020-02-13       Impact factor: 3.332

7.  Antidepressants modulate the in vitro inhibitory effects of propofol and ketamine on norepinephrine and serotonin transporter function.

Authors:  Yejun Zhao; Lena Sun
Journal:  J Clin Neurosci       Date:  2008-09-23       Impact factor: 1.961

8.  Influence of repeated levodopa administration on rabbit striatal serotonin metabolism, and comparison between striatal and CSF alterations.

Authors:  D A Loeffler; P A LeWitt; P L Juneau; D M Camp; A J DeMaggio; M K Havaich; P E Milbury; W R Matson
Journal:  Neurochem Res       Date:  1998-12       Impact factor: 3.996

9.  Independent effects of cholinergic and serotonergic lesions on acetylcholine and serotonin release in the neocortex of the rat.

Authors:  A J Dekker; L J Thal
Journal:  Neurochem Res       Date:  1993-03       Impact factor: 3.996

10.  Ketamine pharmacology: an update (pharmacodynamics and molecular aspects, recent findings).

Authors:  Georges Mion; Thierry Villevieille
Journal:  CNS Neurosci Ther       Date:  2013-04-10       Impact factor: 5.243
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