PURPOSE: Preoperative elevation of serum C-reactive protein (CRP) is a prognostic indicator for some malignant tumors. We investigated the clinicopathologic importance of an elevated preoperative serum CRP value in gastric carcinoma patients. METHODS: We studied the relationship between the preoperative serum CRP value and clinicopathologic characteristics in 204 patients who underwent curative resection of gastric carcinoma. RESULTS: The patients with preoperative CRP elevation had significantly poorer survival than those without CRP elevation (P < 0.0001). According to multivariate analysis, the factors independently associated with an unfavorable prognosis were a high preoperative CRP value (P = 0.024), lymphatic invasion (P = 0.017) and advanced tumor stage (P = 0.016). CONCLUSION: Preoperative serum CRP elevation can be an independent prognostic indicator in patients with gastric carcinoma.
PURPOSE: Preoperative elevation of serum C-reactive protein (CRP) is a prognostic indicator for some malignant tumors. We investigated the clinicopathologic importance of an elevated preoperative serum CRP value in gastric carcinomapatients. METHODS: We studied the relationship between the preoperative serum CRP value and clinicopathologic characteristics in 204 patients who underwent curative resection of gastric carcinoma. RESULTS: The patients with preoperative CRP elevation had significantly poorer survival than those without CRP elevation (P < 0.0001). According to multivariate analysis, the factors independently associated with an unfavorable prognosis were a high preoperative CRP value (P = 0.024), lymphatic invasion (P = 0.017) and advanced tumor stage (P = 0.016). CONCLUSION: Preoperative serum CRP elevation can be an independent prognostic indicator in patients with gastric carcinoma.
Authors: Tomasz M Beer; Alshad S Lalani; Stella Lee; Motomi Mori; Kristine M Eilers; John G Curd; W David Henner; Christopher W Ryan; Peter Venner; J Dean Ruether; Kim N Chi Journal: Cancer Date: 2008-06 Impact factor: 6.860
Authors: Lukas A Hefler; Nicole Concin; Gerda Hofstetter; Christian Marth; Alexander Mustea; Jalid Sehouli; Robert Zeillinger; Heinz Leipold; Harald Lass; Christoph Grimm; Clemens B Tempfer; Alexander Reinthaller Journal: Clin Cancer Res Date: 2008-02-01 Impact factor: 12.531