| Literature DB >> 21428274 |
Wai-Sum Yap1, Chew-Yan Gan, Yun-Yee Low, Yeun-Mun Choo, Tadahiro Etoh, Masahiko Hayashi, Kanki Komiyama, Toh-Seok Kam.
Abstract
Three new indole alkaloids (1-3), named grandilodines A-C, and five known ones were obtained from the Malayan Kopsia grandifolia. The structures were established using NMR and MS analyses and, in the case of 1 and 2, were confirmed by X-ray diffraction analyses. Alkaloids 1, 3, and lapidilectine B (8) were found to reverse multidrug resistance in vincristine-resistant KB cells.Entities:
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Year: 2011 PMID： 21428274 DOI： 10.1021/np200008g
Source DB: PubMed Journal: J Nat Prod ISSN： 0163-3864 Impact factor: 4.050