Literature DB >> 21426051

Pharmacokinetic-pharmacodynamic reasoning in drug discovery and early development.

Piet H Van Der Graaf, Johan Gabrielsson.   

Abstract

Mesh：

Year:  2009        PMID： 21426051     DOI： 10.4155/fmc.09.124

Source DB:  PubMed          Journal:  Future Med Chem        ISSN： 1756-8919            Impact factor:   3.808


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  11 in total

1.  Systems pharmacology: bridging systems biology and pharmacokinetics-pharmacodynamics (PKPD) in drug discovery and development.

Authors:  Piet H van der Graaf; Neil Benson
Journal:  Pharm Res       Date:  2011-05-11       Impact factor: 4.200

2.  Quantitative pharmacological analysis of antagonist binding kinetics at CRF1 receptors in vitro and in vivo.

Authors:  Simeon J Ramsey; Neil J Attkins; Rebecca Fish; Piet H van der Graaf
Journal:  Br J Pharmacol       Date:  2011-10       Impact factor: 8.739

Review 3.  Molecular mechanism matters: Benefits of mechanistic computational models for drug development.

Authors:  Lindsay E Clegg; Feilim Mac Gabhann
Journal:  Pharmacol Res       Date:  2015-06-18       Impact factor: 7.658

4.  In vivo and ex vivo inhibition of spinal nerve ligation-induced ectopic activity by sodium channel blockers correlate to in vitro inhibition of NaV1.7 and clinical efficacy: a pharmacokinetic-pharmacodynamic translational approach.

Authors:  Ivana Kalezic; Lei Luo; Per-Eric Lund; Anders B Eriksson; Tjerk Bueters; Sandra A G Visser
Journal:  Pharm Res       Date:  2013-02-01       Impact factor: 4.200

Review 5.  Modeling, simulation, and translation framework for the preclinical development of monoclonal antibodies.

Authors:  Kenneth T Luu; Eugenia Kraynov; Bing Kuang; Paolo Vicini; Wei-Zhu Zhong
Journal:  AAPS J       Date:  2013-02-14       Impact factor: 4.009

6.  Drug Delivery: Enabling Technology for Drug Discovery and Development. iPRECIO Micro Infusion Pump: Programmable, Refillable, and Implantable.

Authors:  Tsung Tan; Stephanie W Watts; Robert Patrick Davis
Journal:  Front Pharmacol       Date:  2011-07-29       Impact factor: 5.810

7.  A Survey of Software Tool Utilization and Capabilities for Quantitative Systems Pharmacology: What We Have and What We Need.

Authors:  Sergey Ermakov; Brian J Schmidt; Cynthia J Musante; Craig J Thalhauser
Journal:  CPT Pharmacometrics Syst Pharmacol       Date:  2019-01-30

Review 8.  Recent applications of quantitative systems pharmacology and machine learning models across diseases.

Authors:  Sara Sadat Aghamiri; Rada Amin; Tomáš Helikar
Journal:  J Pharmacokinet Pharmacodyn       Date:  2021-10-20       Impact factor: 2.410

Review 9.  Integrating Multiscale Modeling with Drug Effects for Cancer Treatment.

Authors:  Xiangfang L Li; Wasiu O Oduola; Lijun Qian; Edward R Dougherty
Journal:  Cancer Inform       Date:  2016-01-13

Review 10.  Modeling Pharmacokinetics and Pharmacodynamics of Therapeutic Antibodies: Progress, Challenges, and Future Directions.

Authors:  Yu Tang; Yanguang Cao
Journal:  Pharmaceutics       Date:  2021-03-21       Impact factor: 6.321
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