Literature DB >> 21425841

Impact of local versus global ligand density on cellular adhesion.

Janosch A Deeg1, Ilia Louban, Daniel Aydin, Christine Selhuber-Unkel, Horst Kessler, Joachim P Spatz.   

Abstract

α(v)β(3) integrin-mediated cell adhesion is crucially influenced by how far ligands are spaced apart. To evaluate the impact of local ligand density versus global ligand density of a given surface, we used synthetic micronanostructured cell environments with user-defined ligand spacing and patterns to investigate cellular adhesion. The development of stable focal adhesions, their number, and size as well as the cellular adhesion strength proved to be influenced by local more than global ligand density.

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Year:  2011        PMID： 21425841      PMCID： PMC3806292          DOI： 10.1021/nl104079r

Source DB:  PubMed          Journal:  Nano Lett        ISSN： 1530-6984            Impact factor:   11.189


  35 in total

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6.  Micro-nanostructured protein arrays: a tool for geometrically controlled ligand presentation.

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  26 in total

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Review 7.  Elucidating the molecular mechanisms underlying cellular response to biophysical cues using synthetic biology approaches.

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8.  Fundamental Characteristics of Neuron Adhesion Revealed by Forced Peeling and Time-Dependent Healing.

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9.  Dendrimer-based Uneven Nanopatterns to Locally Control Surface Adhesiveness: A Method to Direct Chondrogenic Differentiation.

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10.  Area and Geometry Dependence of Cell Migration in Asymmetric Two-State Micropatterns.

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