Literature DB >> 17671451

Functional atlas of the integrin adhesome.

Ronen Zaidel-Bar1, Shalev Itzkovitz, Avi Ma'ayan, Ravi Iyengar, Benjamin Geiger.   

Abstract

A detailed depiction of the 'integrin adhesome', consisting of a complex network of 156 components linked together and modified by 690 interactions is presented. Different views of the network reveal several functional 'subnets' that are involved in switching on or off many of the molecular interactions within the network, consequently affecting cell adhesion, migration and cytoskeletal organization. Examination of the adhesome network motifs reveals a relatively small number of key motifs, dominated by three-component complexes in which a scaffolding molecule recruits both a signalling molecule and its downstream target. We discuss the role of the different network modules in regulating the structural and signalling functions of cell-matrix adhesions.

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Year:  2007        PMID： 17671451      PMCID： PMC2735470          DOI： 10.1038/ncb0807-858

Source DB:  PubMed          Journal:  Nat Cell Biol        ISSN： 1465-7392            Impact factor:   28.824


  37 in total

1.  Network motifs: simple building blocks of complex networks.

Authors:  R Milo; S Shen-Orr; S Itzkovitz; N Kashtan; D Chklovskii; U Alon
Journal:  Science       Date:  2002-10-25       Impact factor: 47.728

2.  BIND: the Biomolecular Interaction Network Database.

Authors:  Gary D Bader; Doron Betel; Christopher W V Hogue
Journal:  Nucleic Acids Res       Date:  2003-01-01       Impact factor: 16.971

Review 3.  Paxillin: adapting to change.

Authors:  Michael C Brown; Christopher E Turner
Journal:  Physiol Rev       Date:  2004-10       Impact factor: 37.312

4.  ProViz: protein interaction visualization and exploration.

Authors:  Florian Iragne; Macha Nikolski; Bertrand Mathieu; David Auber; David Sherman
Journal:  Bioinformatics       Date:  2004-09-03       Impact factor: 6.937

5.  Towards a proteome-scale map of the human protein-protein interaction network.

Authors:  Jean-François Rual; Kavitha Venkatesan; Tong Hao; Tomoko Hirozane-Kishikawa; Amélie Dricot; Ning Li; Gabriel F Berriz; Francis D Gibbons; Matija Dreze; Nono Ayivi-Guedehoussou; Niels Klitgord; Christophe Simon; Mike Boxem; Stuart Milstein; Jennifer Rosenberg; Debra S Goldberg; Lan V Zhang; Sharyl L Wong; Giovanni Franklin; Siming Li; Joanna S Albala; Janghoo Lim; Carlene Fraughton; Estelle Llamosas; Sebiha Cevik; Camille Bex; Philippe Lamesch; Robert S Sikorski; Jean Vandenhaute; Huda Y Zoghbi; Alex Smolyar; Stephanie Bosak; Reynaldo Sequerra; Lynn Doucette-Stamm; Michael E Cusick; David E Hill; Frederick P Roth; Marc Vidal
Journal:  Nature       Date:  2005-09-28       Impact factor: 49.962

6.  Molecular characterization and comparison of the components and multiprotein complexes in the postsynaptic proteome.

Authors:  Mark O Collins; Holger Husi; Lu Yu; Julia M Brandon; Chris N G Anderson; Walter P Blackstock; Jyoti S Choudhary; Seth G N Grant
Journal:  J Neurochem       Date:  2006-04       Impact factor: 5.372

7.  Lateral spacing of integrin ligands influences cell spreading and focal adhesion assembly.

Authors:  Elisabetta A Cavalcanti-Adam; Alexandre Micoulet; Jacques Blümmel; Jörg Auernheimer; Horst Kessler; Joachim P Spatz
Journal:  Eur J Cell Biol       Date:  2005-10-10       Impact factor: 4.492

8.  Taking cell-matrix adhesions to the third dimension.

Authors:  E Cukierman; R Pankov; D R Stevens; K M Yamada
Journal:  Science       Date:  2001-11-23       Impact factor: 47.728

Review 9.  The molecular basis and specificity of integrin-ligand interactions.

Authors:  M J Humphries
Journal:  J Cell Sci       Date:  1990-12       Impact factor: 5.285

10.  Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice.

Authors:  P Soriano; C Montgomery; R Geske; A Bradley
Journal:  Cell       Date:  1991-02-22       Impact factor: 41.582
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  467 in total

1.  Human protein reference database and human proteinpedia as discovery resources for molecular biotechnology.

Authors:  Renu Goel; Babylakshmi Muthusamy; Akhilesh Pandey; T S Keshava Prasad
Journal:  Mol Biotechnol       Date:  2011-05       Impact factor: 2.695

2.  Subcellular localization of talin is regulated by inter-domain interactions.

Authors:  Asoka Banno; Benjamin T Goult; HoSup Lee; Neil Bate; David R Critchley; Mark H Ginsberg
Journal:  J Biol Chem       Date:  2012-02-18       Impact factor: 5.157

3.  S100A4 downregulates filopodia formation through increased dynamic instability.

Authors:  Connie Goh Then Sin; Nils Hersch; Philip S Rudland; Roger Barraclough; Bernd Hoffmann; Stephane R Gross
Journal:  Cell Adh Migr       Date:  2011 Sep-Oct       Impact factor: 3.405

4.  Dissecting the molecular architecture of integrin adhesion sites by cryo-electron tomography.

Authors:  Israel Patla; Tova Volberg; Nadav Elad; Vera Hirschfeld-Warneken; Carsten Grashoff; Reinhard Fässler; Joachim P Spatz; Benjamin Geiger; Ohad Medalia
Journal:  Nat Cell Biol       Date:  2010-08-08       Impact factor: 28.824

Review 5.  The switchable integrin adhesome.

Authors:  Ronen Zaidel-Bar; Benjamin Geiger
Journal:  J Cell Sci       Date:  2010-05-01       Impact factor: 5.285

6.  Neurons sense nanoscale roughness with nanometer sensitivity.

Authors:  V Brunetti; G Maiorano; L Rizzello; B Sorce; S Sabella; R Cingolani; P P Pompa
Journal:  Proc Natl Acad Sci U S A       Date:  2010-03-22       Impact factor: 11.205

7.  Intercellular mechanotransduction during multicellular morphodynamics.

Authors:  Jin-Hong Kim; Lawrence J Dooling; Anand R Asthagiri
Journal:  J R Soc Interface       Date:  2010-03-31       Impact factor: 4.118

8.  Spatial association of the Cav1.2 calcium channel with α5β1-integrin.

Authors:  Jun-Tzu Chao; Peichun Gui; Gerald W Zamponi; George E Davis; Michael J Davis
Journal:  Am J Physiol Cell Physiol       Date:  2010-12-22       Impact factor: 4.249

9.  The SHCA adapter protein cooperates with lipoma-preferred partner in the regulation of adhesion dynamics and invadopodia formation.

Authors:  Alex Kiepas; Elena Voorand; Julien Senecal; Ryuhjin Ahn; Matthew G Annis; Kévin Jacquet; George Tali; Nicolas Bisson; Josie Ursini-Siegel; Peter M Siegel; Claire M Brown
Journal:  J Biol Chem       Date:  2020-04-16       Impact factor: 5.157

10.  Ultraviolet B Inhibits Skin Wound Healing by Affecting Focal Adhesion Dynamics.

Authors:  Han Liu; Jiping Yue; Qiang Lei; Xuewen Gou; Shao-Yu Chen; Yu-Ying He; Xiaoyang Wu
Journal:  Photochem Photobiol       Date:  2015-05-16       Impact factor: 3.421
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