Literature DB >> 21424342

Influence of sCD40L on gastric cancer cell lines.

Rui Li1, Wei-Chang Chen, Xue-Qin Pang, Wen-Yan Tian, Xue-Guang Zhang.   

Abstract

The CD40 signaling pathway plays a key role in tumor cell proliferation, differentiation, and apoptosis. Gastric cancer usually possesses a higher level of CD40 expression than normal tissue. We evaluated inhibition of soluble CD40 ligand (sCD40L) in apoptosis induction of gastric cancer cells. Gastric cancer cells (AGS and BGC-823) were incubated with sCD40L. Cell viability and cell cycle were determined by methyl-tetrazolium (MTT) assay and flow cytometry, respectively. The results showed that sCD40L hindered cell growth, arrested cells at G0/G1 phase and induced apoptosis. In conclusion, sCD40L suppress growth of gastric cancer cells through apoptosis induction and cell cycle quiescence. This work will provided a new approach to gene therapy of gastric cancer.

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Year:  2011        PMID： 21424342     DOI： 10.1007/s11033-011-0702-9

Source DB:  PubMed          Journal:  Mol Biol Rep        ISSN： 0301-4851            Impact factor:   2.316


  28 in total

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Journal:  Int J Cancer       Date:  2002-11-01       Impact factor: 7.396

2.  An investigation on the polymorphisms of two DNA repair genes and susceptibility to ESCC and GCA of high-incidence region in northern China.

Authors:  Na Wang; Xiu-Juan Dong; Rong-Miao Zhou; Wei Guo; Xiao-Juan Zhang; Yan Li
Journal:  Mol Biol Rep       Date:  2007-11-29       Impact factor: 2.316

3.  Membranes from both Th1 and Th2 T cell clones stimulate B cell proliferation and prepare B cells for lymphokine-induced differentiation to secrete Ig.

Authors:  P D Hodgkin; L C Yamashita; B Seymour; R L Coffman; M R Kehry
Journal:  J Immunol       Date:  1991-12-01       Impact factor: 5.422

4.  CD40 signaling activated by agonistic anti-CD40 monoclonal antibody 5C11 has different effects on biological behavior of gastric carcinoma cells.

Authors:  Rui Li; Wei-chang Chen; Wei-peng Wang; Wen-yan Tian; Xue-guang Zhang
Journal:  Immunol Lett       Date:  2010-02-25       Impact factor: 3.685

5.  Phenotypic and functional characterization of clinical grade dendritic cells generated from patients with advanced breast cancer for therapeutic vaccination.

Authors:  A E Pedersen; M Thorn; M Gad; M R Walter; H E Johnsen; E Gaarsdal; K Nikolajsen; S Buus; M H Claesson; I M Svane
Journal:  Scand J Immunol       Date:  2005-02       Impact factor: 3.487

6.  Role for CD40-CD40 ligand interactions in the immune response to solid tumours.

Authors:  A B Alexandroff; A M Jackson; T Paterson; J L Haley; J A Ross; D L Longo; W J Murphy; K James; D D Taub
Journal:  Mol Immunol       Date:  2000-06       Impact factor: 4.407

7.  CD40 is functionally expressed on human breast carcinomas: variable inducibility by cytokines and enhancement of Fas-mediated apoptosis.

Authors:  D G Wingett; R E Vestal; K Forcier; N Hadjokas; C P Nielson
Journal:  Breast Cancer Res Treat       Date:  1998-07       Impact factor: 4.872

8.  Overexpression of PIP5KL1 suppresses cell proliferation and migration in human gastric cancer cells.

Authors:  Lan Shi; Mei Zhao; Qing Luo; Yi-Ming Ma; Jia-Ling Zhong; Xing-Hua Yuan; Chang-Zhi Huang
Journal:  Mol Biol Rep       Date:  2009-08-13       Impact factor: 2.316

9.  Association of cytotoxic T lymphocyte-associated antigen-4 gene haplotype with the susceptibility to gastric cancer.

Authors:  Ruiping Hou; Bangwei Cao; Zhongdong Chen; Yong Li; Tao Ning; Chunhui Li; Changqing Xu; Ziping Chen
Journal:  Mol Biol Rep       Date:  2009-08-18       Impact factor: 2.316

10.  Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation.

Authors:  M Cella; D Scheidegger; K Palmer-Lehmann; P Lane; A Lanzavecchia; G Alber
Journal:  J Exp Med       Date:  1996-08-01       Impact factor: 14.307
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  1 in total

1.  Gastric cancer cell lines AGS before and after CD40 signal activating.

Authors:  Rui Li; Xue-Qin Pang; Wei-Chang Chen; Ling Li; Wen-Yan Tian; Xue-Guang Zhang
Journal:  Mol Biol Rep       Date:  2012-02-21       Impact factor: 2.316
  1 in total

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