PURPOSE: This study was undertaken to assess whether there is a correlation between the response of cervical tumours to nonsurgical therapy (chemo- and/or radiotherapy) and apparent diffusion coefficient (ADC) values. PATIENTS AND METHODS: Seventeen consecutive patients prospectively underwent pelvic magnetic resonance (MR) imaging including diffusion-weighted imaging (DWI) sequences before and after nonsurgical therapy for cervical cancer. A control group of 17 patients without cervical pathology was matched to the study group. Differences in baseline ADC maps between the two groups and within the study group before and after therapy were assessed by nonparametric tests. RESULTS: The diameter and volume of cervical cancers decreased after therapy in 14/17 lesions (responders) and increased in 3/17 lesions (nonresponders). The ADC values of responders increased significantly (p=0.0009). Percent changes in ADC values before and after therapy were higher in responders than nonresponders (p=0.04). There was no significant difference in ADC values between responders and nonresponders at the staging MR examination (p=0.09) and no significant correlation between pretreatment ADC values and percentage of tumour reduction. Tumours with higher percent ADC value increase showed higher tumour reduction volume, but this was not significant (p=0.12). CONCLUSIONS: ADC values of cervical cancer after therapy showed significant differences compared with pretherapy values, particularly for responders.
PURPOSE: This study was undertaken to assess whether there is a correlation between the response of cervical tumours to nonsurgical therapy (chemo- and/or radiotherapy) and apparent diffusion coefficient (ADC) values. PATIENTS AND METHODS: Seventeen consecutive patients prospectively underwent pelvic magnetic resonance (MR) imaging including diffusion-weighted imaging (DWI) sequences before and after nonsurgical therapy for cervical cancer. A control group of 17 patients without cervical pathology was matched to the study group. Differences in baseline ADC maps between the two groups and within the study group before and after therapy were assessed by nonparametric tests. RESULTS: The diameter and volume of cervical cancers decreased after therapy in 14/17 lesions (responders) and increased in 3/17 lesions (nonresponders). The ADC values of responders increased significantly (p=0.0009). Percent changes in ADC values before and after therapy were higher in responders than nonresponders (p=0.04). There was no significant difference in ADC values between responders and nonresponders at the staging MR examination (p=0.09) and no significant correlation between pretreatment ADC values and percentage of tumour reduction. Tumours with higher percent ADC value increase showed higher tumour reduction volume, but this was not significant (p=0.12). CONCLUSIONS: ADC values of cervical cancer after therapy showed significant differences compared with pretherapy values, particularly for responders.
Authors: Harriet C Thoeny; Frederik De Keyzer; Vincent Vandecaveye; Feng Chen; Xihe Sun; Hilde Bosmans; Robert Hermans; Eric K Verbeken; Chris Boesch; Guy Marchal; Willy Landuyt; Yicheng Ni Journal: Radiology Date: 2005-09-28 Impact factor: 11.105
Authors: R Manfredi; B Gui; A Giovanzana; S Marini; M Di Stefano; G Zannoni; G Scambia; L Bonomo Journal: Radiol Med Date: 2009-05-14 Impact factor: 3.469
Authors: Jeffrey R Olsen; Jacqueline Esthappan; Todd DeWees; Vamsi R Narra; Farrokh Dehdashti; Barry A Siegel; Julie K Schwarz; Perry W Grigsby Journal: J Magn Reson Imaging Date: 2012-09-28 Impact factor: 4.813
Authors: Pietro Valerio Foti; Renato Farina; Maria Coronella; Stefano Palmucci; Noemi Ognibene; Pietro Milone; Cristina Conti Bellocchi; Leonardo Samperi; Gaetano Inserra; Andrea Laghi; Giovanni Carlo Ettorre Journal: Radiol Med Date: 2015-02-04 Impact factor: 3.469