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Literature DB >> 21424019

A smart magnetic resonance imaging contrast agent responsive to adenosine based on a DNA aptamer-conjugated gadolinium complex.

Abstract

We report a general strategy for developing a smart MRI contrast agent for the sensing of small molecules such as adenosine based on a DNA aptamer that is conjugated to a Gd compound and a protein streptavidin. The binding of adenosine to its aptamer results in the dissociation of the Gd compound from the large protein, leading to decreases in the rotational correlation time and thus change of MRI contrast. © The Royal Society of Chemistry 2011

Entities: Chemical Species

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Year: 2011 PMID： 21424019 PMCID： PMC3298773 DOI： 10.1039/c1cc10161g

Source DB: PubMed Journal: Chem Commun (Camb) ISSN： 1359-7345 Impact factor: 6.222

45 in total

1. A paramagnetic MRI-CEST agent responsive to lactate concentration.

Authors: Silvio Aime; Daniela Delli Castelli; Franco Fedeli; Enzo Terreno
Journal: J Am Chem Soc Date: 2002-08-14 Impact factor: 15.419

Review 2. New magnetic resonance contrast agents as biochemical reporters.

Authors: Thomas J Meade; Alisha K Taylor; Steven R Bull
Journal: Curr Opin Neurobiol Date: 2003-10 Impact factor: 6.627

3. Electrochemical interrogation of conformational changes as a reagentless method for the sequence-specific detection of DNA.

Authors: Chunhai Fan; Kevin W Plaxco; Alan J Heeger
Journal: Proc Natl Acad Sci U S A Date: 2003-07-16 Impact factor: 11.205

A smart magnetic resonance imaging contrast agent responsive to adenosine based on a DNA aptamer-conjugated gadolinium complex.

1. A paramagnetic MRI-CEST agent responsive to lactate concentration.

Review 2. New magnetic resonance contrast agents as biochemical reporters.

3. Electrochemical interrogation of conformational changes as a reagentless method for the sequence-specific detection of DNA.

4. Structure-switching signaling aptamers.

5. Label-free electronic detection of thrombin in blood serum by using an aptamer-based sensor.

6. In vitro selection of structure-switching signaling aptamers.

7. Preparation of aptamer-linked gold nanoparticle purple aggregates for colorimetric sensing of analytes.

8. Paramagnetic relaxation-based 19f MRI probe to detect protease activity.

9. A DNA enzyme that cleaves RNA.

10. Copper-responsive magnetic resonance imaging contrast agents.

Review 1. Molecular imaging with nucleic acid aptamers.

2. A smart T(1)-weighted MRI contrast agent for uranyl cations based on a DNAzyme-gadolinium conjugate.

3. New insights into a classic aptamer: binding sites, cooperativity and more sensitive adenosine detection.

4. A (Fluoroalkyl)Guanidine Modulates the Relaxivity of a Phosphonate-Containing T₁-Shortening Contrast Agent.

5. Direct detection of adenosine in undiluted serum using a luminescent aptamer sensor attached to a terbium complex.

Review 6. Applications of aptamers in targeted imaging: state of the art.

7. Imparting the unique properties of DNA into complex material architectures and functions.

Review 8. A review of responsive MRI contrast agents: 2005-2014.

Review 9. Environmentally responsive MRI contrast agents.

10. Target binding improves relaxivity in aptamer-gadolinium conjugates.