OBJECTIVE: To compare the rates of Chlamydia trachomatis detection using urine and cervical secretions from pregnant women at our institution. METHODS: A large cross-sectional sample of pregnant women (N=2,018) at 35-37 weeks of gestation were tested for C trachomatis with both endocervical and urine sampling using the Aptima Combo 2 Assay. RESULTS: A prevalence of 4.3% and 4.1% were found for Chlamydia endocervical and urine samples, respectively. There was no difference between the two tests by McNemar's test (-0.02%, 0.32%; P=.083). There was excellent correlation between the tests found by the κ statistic (0.982 [0.961-1.000]). CONCLUSION: Urine sampling for C trachomatis is equivalent to endocervical sampling in pregnancy using the Aptima 2 Combo Assay. LEVEL OF EVIDENCE: II.
OBJECTIVE: To compare the rates of Chlamydia trachomatis detection using urine and cervical secretions from pregnant women at our institution. METHODS: A large cross-sectional sample of pregnant women (N=2,018) at 35-37 weeks of gestation were tested for C trachomatis with both endocervical and urine sampling using the Aptima Combo 2 Assay. RESULTS: A prevalence of 4.3% and 4.1% were found for Chlamydia endocervical and urine samples, respectively. There was no difference between the two tests by McNemar's test (-0.02%, 0.32%; P=.083). There was excellent correlation between the tests found by the κ statistic (0.982 [0.961-1.000]). CONCLUSION: Urine sampling for C trachomatis is equivalent to endocervical sampling in pregnancy using the Aptima 2 Combo Assay. LEVEL OF EVIDENCE: II.
Authors: Carole Lunny; Darlene Taylor; Linda Hoang; Tom Wong; Mark Gilbert; Richard Lester; Mel Krajden; Gina Ogilvie Journal: PLoS One Date: 2015-07-13 Impact factor: 3.240