PURPOSE: UVB radiation from sunlight is known to be a risk factor for human cataract. The purpose in this study was to investigate the ability of a class I UV-blocking soft contact lens to protect against UVB-induced effects on the ocular tissues of the rabbit in vivo. METHODS: Eyes of rabbits were exposed to UVB light for 30 minutes (270-360 nm, peak at 310 nm, 1.7 mW/cm(2) on the cornea). Eyes were irradiated in the presence of either a UV-blocking senofilcon A contact lens, a minimally UV-blocking lotrafilcon A contact lens, or no contact lens at all. Effects on the cornea and lens were evaluated at various times after exposure. RESULTS: Eyes irradiated with no contact lens protection showed corneal epithelial cell loss plus lens epithelial cell swelling, vacuole formation, and DNA single-strand breaks, as well as lens anterior subcapsular opacification. The senofilcon A lens protected nearly completely against the UVB-induced effects, whereas the lotrafilcon A lens showed no protection. CONCLUSIONS: The results indicate that use of a senofilcon A contact lens is beneficial in protecting ocular tissues of the rabbit against the harmful effects of UVB light, including photokeratitis and cataract.
PURPOSE: UVB radiation from sunlight is known to be a risk factor for humancataract. The purpose in this study was to investigate the ability of a class I UV-blocking soft contact lens to protect against UVB-induced effects on the ocular tissues of the rabbit in vivo. METHODS: Eyes of rabbits were exposed to UVB light for 30 minutes (270-360 nm, peak at 310 nm, 1.7 mW/cm(2) on the cornea). Eyes were irradiated in the presence of either a UV-blocking senofilcon A contact lens, a minimally UV-blocking lotrafilcon A contact lens, or no contact lens at all. Effects on the cornea and lens were evaluated at various times after exposure. RESULTS: Eyes irradiated with no contact lens protection showed corneal epithelial cell loss plus lens epithelial cell swelling, vacuole formation, and DNA single-strand breaks, as well as lens anterior subcapsular opacification. The senofilcon A lens protected nearly completely against the UVB-induced effects, whereas the lotrafilcon A lens showed no protection. CONCLUSIONS: The results indicate that use of a senofilcon A contact lens is beneficial in protecting ocular tissues of the rabbit against the harmful effects of UVB light, including photokeratitis and cataract.
Authors: Momchil D Vodenicharov; Medini M Ghodgaonkar; Sabina S Halappanavar; Rashmi G Shah; Girish M Shah Journal: J Cell Sci Date: 2005-01-18 Impact factor: 5.285
Authors: Nathan Congdon; Johannes R Vingerling; Barbara E K Klein; Sheila West; David S Friedman; John Kempen; Benita O'Colmain; Suh-Yuh Wu; Hugh R Taylor Journal: Arch Ophthalmol Date: 2004-04
Authors: Mustafa Unal; Mehmet Güven; Bahadir Batar; Ahmet Ozaydin; Ahmet Sarici; Kazim Devranoğlu Journal: Exp Eye Res Date: 2007-06-14 Impact factor: 3.467
Authors: M Notara; S Behboudifard; M A Kluth; C Maßlo; C Ganss; M H Frank; B Schumacher; C Cursiefen Journal: Sci Rep Date: 2018-08-22 Impact factor: 4.379