UNLABELLED: The purpose of this study was to identify the incidence and clinical significance of incidental pituitary uptake on whole-body (18)F-FDG PET/CT. METHODS: We evaluated 13,145 consecutive subjects who underwent (18)F-FDG PET/CT. The final diagnosis of pathologic or physiologic uptake was based on brain MRI and follow-up PET scanning. Receiver-operating-characteristic curve analysis was performed to determine an optimal cutoff for detecting pathologic uptake. RESULTS: We found that 107 (0.8%) subjects showed incidental pituitary uptake. In 29 of 71 subjects with the final diagnosis, the pituitary uptake was pathologic: macroadenomas (n = 21), microadenomas (n = 5), and malignancy (n = 3). When a maximum standardized uptake value of 4.1 was used as an optimal criterion for detecting pathologic uptake, the diagnostic sensitivity, specificity, and accuracy were 96.6%, 88.1%, and 91.5%, respectively. CONCLUSION: Although incidental pituitary uptake is an unusual finding, the degree of (18)F-FDG accumulation is helpful in identifying pathologic pituitary lesions that warrant further diagnostic evaluation.
UNLABELLED: The purpose of this study was to identify the incidence and clinical significance of incidental pituitary uptake on whole-body (18)F-FDG PET/CT. METHODS: We evaluated 13,145 consecutive subjects who underwent (18)F-FDG PET/CT. The final diagnosis of pathologic or physiologic uptake was based on brain MRI and follow-up PET scanning. Receiver-operating-characteristic curve analysis was performed to determine an optimal cutoff for detecting pathologic uptake. RESULTS: We found that 107 (0.8%) subjects showed incidental pituitary uptake. In 29 of 71 subjects with the final diagnosis, the pituitary uptake was pathologic: macroadenomas (n = 21), microadenomas (n = 5), and malignancy (n = 3). When a maximum standardized uptake value of 4.1 was used as an optimal criterion for detecting pathologic uptake, the diagnostic sensitivity, specificity, and accuracy were 96.6%, 88.1%, and 91.5%, respectively. CONCLUSION: Although incidental pituitary uptake is an unusual finding, the degree of (18)F-FDG accumulation is helpful in identifying pathologic pituitary lesions that warrant further diagnostic evaluation.
Authors: Marc C Mabray; Spencer C Behr; David M Naeger; Robert R Flavell; Christine M Glastonbury Journal: Clin Imaging Date: 2015-07-16 Impact factor: 1.605
Authors: Ji Young Lee; Joon Young Choi; Yoon-Ho Choi; Seung Hyup Hyun; Seung Hwan Moon; Su Jin Jang; Yearn Seong Choe; Kyung-Han Lee; Byung-Tae Kim Journal: Korean J Radiol Date: 2013-05-02 Impact factor: 3.500