| Literature DB >> 21420977 |
Abstract
The "Operon paper" by F. Jacob and J. Monod started 50 years of research into understanding how the expression of genes is regulated on a molecular level. Ten years ago, microRNAs (miRNAs) emerged as major regulators of eukaryotic gene expression. Here, I will review the basic principles of gene regulation by miRNAs and how these principles can be linked to insights from the Operon paper. A lot of what is understood about miRNAs required a combination of computational and experimental methods. I will discuss some examples that illustrate the power of this approach.Mesh：
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Year: 2011 PMID： 21420977 DOI： 10.1016/j.jmb.2011.03.021
Source DB: PubMed Journal: J Mol Biol ISSN： 0022-2836 Impact factor: 5.469