BACKGROUND: Research using experimental autoimmune encephalitis (EAE) models accounts for almost 20% of the papers. published in multiple sclerosis (MS). METHODS: We performed a literature review of papers indexed with ISI Web of Science on EAE and MS over the last 30 years and a detailed analysis of studies of molecular pathways in EAE published in 2008 and 2009. RESULTS: The impact of EAE studies declines more rapidly than other studies published on MS (EAE cited corrected half-life = 4·00 years vs. MS cited corrected half-life = 9·66 years, P < 0·0001). The pathology of EAE differs quite markedly from that observed in the human disease. EAE has implicated many different genes as important to pathogenesis but only a minority of these are supported by human studies. CONCLUSIONS: Future research should critically appraise precisely what is being modelled by EAE before drawing conclusions about human disease.
BACKGROUND: Research using experimental autoimmune encephalitis (EAE) models accounts for almost 20% of the papers. published in multiple sclerosis (MS). METHODS: We performed a literature review of papers indexed with ISI Web of Science on EAE and MS over the last 30 years and a detailed analysis of studies of molecular pathways in EAE published in 2008 and 2009. RESULTS: The impact of EAE studies declines more rapidly than other studies published on MS (EAE cited corrected half-life = 4·00 years vs. MS cited corrected half-life = 9·66 years, P < 0·0001). The pathology of EAE differs quite markedly from that observed in the human disease. EAE has implicated many different genes as important to pathogenesis but only a minority of these are supported by human studies. CONCLUSIONS: Future research should critically appraise precisely what is being modelled by EAE before drawing conclusions about human disease.
Authors: David A Reardon; Gordon Freeman; Catherine Wu; E Antonio Chiocca; Kai W Wucherpfennig; Patrick Y Wen; Edward F Fritsch; William T Curry; John H Sampson; Glenn Dranoff Journal: Neuro Oncol Date: 2014-09-04 Impact factor: 12.300
Authors: Marcin F Osuchowski; Daniel G Remick; James A Lederer; Charles H Lang; Ansgar O Aasen; Mayuki Aibiki; Luciano C Azevedo; Soheyl Bahrami; Mihaly Boros; Robert Cooney; Salvatore Cuzzocrea; Yong Jiang; Wolfgang G Junger; Hiroyuki Hirasawa; Richard S Hotchkiss; Xiang-An Li; Peter Radermacher; Heinz Redl; Reinaldo Salomao; Amin Soebandrio; Christoph Thiemermann; Jean-Louis Vincent; Peter Ward; Yong-Ming Yao; Huang-Ping Yu; Basilia Zingarelli; Irshad H Chaudry Journal: Shock Date: 2014-06 Impact factor: 3.533
Authors: Suzanne Doolen; Tommaso Iannitti; Renee R Donahue; Benjamin C Shaw; Carolyn M Grachen; Bradley K Taylor Journal: Pain Date: 2018-02 Impact factor: 7.926