Literature DB >> 21415774

Vitamin D: a d-lightful solution for health.

Michael F Holick1.   

Abstract

Throughout evolution, sunlight-produced vitamin D in the skin has been critically important for health. Vitamin D, known as the sunshine vitamin, is actually a hormone. Once it is produced in the skin or ingested from the diet, it is converted sequentially in the liver and kidneys to its biologically active form 1,25-dihydroxyvitamin D. This hormone interacts with its receptor in the small intestine to increase the efficiency of intestinal calcium and phosphate absorption for the maintenance of the skeleton throughout life. Vitamin D deficiency during the first few years of life results in a flattened pelvis, making it difficult for childbirth. Vitamin D deficiency causes osteopenia and osteoporosis, increasing risk of fracture. Essentially, every tissue and cell in the body has a vitamin D receptor. Therefore, vitamin D deficiency has been linked to increased risk for preeclampsia, requiring a cesarean section for birthing, multiple sclerosis, rheumatoid arthritis, types I and II diabetes, heart disease, dementia, deadly cancers, and infectious diseases. Therefore, sensible sun exposure along with vitamin D supplementation of at least 2000 IU/d for adults and 1000 IU/d for children is essential to maximize their health.

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Year:  2011        PMID: 21415774      PMCID: PMC3738435          DOI: 10.2310/JIM.0b013e318214ea2d

Source DB:  PubMed          Journal:  J Investig Med        ISSN: 1081-5589            Impact factor:   2.895


  50 in total

1.  Vitamin D intoxication associated with an over-the-counter supplement.

Authors:  P Koutkia; T C Chen; M F Holick
Journal:  N Engl J Med       Date:  2001-07-05       Impact factor: 91.245

Review 2.  Vitamin D deficiency.

Authors:  Michael F Holick
Journal:  N Engl J Med       Date:  2007-07-19       Impact factor: 91.245

3.  Calcium absorption varies within the reference range for serum 25-hydroxyvitamin D.

Authors:  Robert P Heaney; M Susan Dowell; Cecilia A Hale; Adrianne Bendich
Journal:  J Am Coll Nutr       Date:  2003-04       Impact factor: 3.169

4.  Intake of vitamin D and risk of type 1 diabetes: a birth-cohort study.

Authors:  E Hyppönen; E Läärä; A Reunanen; M R Järvelin; S M Virtanen
Journal:  Lancet       Date:  2001-11-03       Impact factor: 79.321

5.  Increased skin pigment reduces the capacity of skin to synthesise vitamin D3.

Authors:  T L Clemens; J S Adams; S L Henderson; M F Holick
Journal:  Lancet       Date:  1982-01-09       Impact factor: 79.321

6.  Prevalence of severe hypovitaminosis D in patients with persistent, nonspecific musculoskeletal pain.

Authors:  Gregory A Plotnikoff; Joanna M Quigley
Journal:  Mayo Clin Proc       Date:  2003-12       Impact factor: 7.616

Review 7.  Assessment of dietary vitamin D requirements during pregnancy and lactation.

Authors:  Bruce W Hollis; Carol L Wagner
Journal:  Am J Clin Nutr       Date:  2004-05       Impact factor: 7.045

8.  Vitamin D intake is inversely associated with rheumatoid arthritis: results from the Iowa Women's Health Study.

Authors:  Linda A Merlino; Jeffrey Curtis; Ted R Mikuls; James R Cerhan; Lindsey A Criswell; Kenneth G Saag
Journal:  Arthritis Rheum       Date:  2004-01

9.  Human serum 25-hydroxycholecalciferol response to extended oral dosing with cholecalciferol.

Authors:  Robert P Heaney; K Michael Davies; Tai C Chen; Michael F Holick; M Janet Barger-Lux
Journal:  Am J Clin Nutr       Date:  2003-01       Impact factor: 7.045

Review 10.  Ultraviolet radiation and autoimmune disease: insights from epidemiological research.

Authors:  Anne-Louise Ponsonby; Anthony McMichael; Ingrid van der Mei
Journal:  Toxicology       Date:  2002-12-27       Impact factor: 4.221

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  59 in total

Review 1.  Role of circulating factors in cardiac aging.

Authors:  Antonio Cannatà; Gabriella Marcon; Giovanni Cimmino; Luca Camparini; Giulio Ciucci; Gianfranco Sinagra; Francesco S Loffredo
Journal:  J Thorac Dis       Date:  2017-03       Impact factor: 2.895

2.  Vitamin D supplementation associated with physical exercise promotes a tolerogenic immune environment without effect on mammary tumour growth in C57BL/6 mice.

Authors:  Sahar Aldekwer; Adrien Desiderio; Marie-Chantal Farges; Stéphanie Rougé; Augustin Le Naour; Delphine Le Guennec; Nicolas Goncalves-Mendès; Laurence Mille-Hamard; Iman Momken; Adrien Rossary; Mona Diab-Assaf; Marie-Paule Vasson; Jérémie Talvas
Journal:  Eur J Nutr       Date:  2020-11-10       Impact factor: 5.614

3.  Chronic stress causes neuroendocrine-immune disturbances without affecting renal vitamin D metabolism in rats.

Authors:  P Jiang; L Zhang; W Zhu; H Li; R Dang; M Tang
Journal:  J Endocrinol Invest       Date:  2014-10-16       Impact factor: 4.256

4.  Prenatal exposure to vitamin-D from fortified margarine and milk and body size at age 7 years.

Authors:  C B Jensen; M Gamborg; T L Berentzen; T I A Sørensen; B L Heitmann
Journal:  Eur J Clin Nutr       Date:  2015-04-08       Impact factor: 4.016

5.  Vitamin D derivatives enhance cytotoxic effects of H2O2 or cisplatin on human keratinocytes.

Authors:  Anna Piotrowska; Justyna Wierzbicka; Tomasz Ślebioda; Michał Woźniak; Robert C Tuckey; Andrzej T Slominski; Michał A Żmijewski
Journal:  Steroids       Date:  2016-04-13       Impact factor: 2.668

6.  Vitamin D and calcium intake and risk of early menopause.

Authors:  Alexandra C Purdue-Smithe; Brian W Whitcomb; Kathleen L Szegda; Maegan E Boutot; JoAnn E Manson; Susan E Hankinson; Bernard A Rosner; Lisa M Troy; Karin B Michels; Elizabeth R Bertone-Johnson
Journal:  Am J Clin Nutr       Date:  2017-05-10       Impact factor: 7.045

7.  The role of vitamin D in the metabolic homeostasis of diabetic bone.

Authors:  Kathryn M Thrailkill; John L Fowlkes
Journal:  Clin Rev Bone Miner Metab       Date:  2013-03-01

Review 8.  Vitamin D deficiency in early life and the potential programming of cardiovascular disease in adulthood.

Authors:  Oksan Gezmish; Mary Jane Black
Journal:  J Cardiovasc Transl Res       Date:  2013-05-30       Impact factor: 4.132

Review 9.  Vitamin D during pregnancy and maternal, neonatal and infant health outcomes: a systematic review and meta-analysis.

Authors:  Andrew Thorne-Lyman; Wafaie W Fawzi
Journal:  Paediatr Perinat Epidemiol       Date:  2012-07       Impact factor: 3.980

Review 10.  Vitamin D in patients with chronic kidney disease: a position statement of the Working Group "Trace Elements and Mineral Metabolism" of the Italian Society of Nephrology.

Authors:  Luigi Francesco Morrone; Pergiorgio Bolasco; Corrado Camerini; Giuseppe Cianciolo; Adamasco Cupisti; Andrea Galassi; Sandro Mazzaferro; Domenico Russo; Luigi Russo; Mario Cozzolino
Journal:  J Nephrol       Date:  2016-04-09       Impact factor: 3.902

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