Literature DB >> 21415371

Switching cation-binding loops paves the way for redesigning allosteric activation.

Muriel C Maurer1.   

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Year:  2011        PMID： 21415371      PMCID： PMC3069213          DOI： 10.1073/pnas.1102132108

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


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  19 in total

1.  Molecular dissection of Na+ binding to thrombin.

Authors:  Agustin O Pineda; Christopher J Carrell; Leslie A Bush; Swati Prasad; Sonia Caccia; Zhi-Wei Chen; F Scott Mathews; Enrico Di Cera
Journal:  J Biol Chem       Date:  2004-05-19       Impact factor: 5.157

2.  Redesigning the monovalent cation specificity of an enzyme.

Authors:  Swati Prasad; Kelly J Wright; Dolly Banerjee Roy; Leslie A Bush; Angelene M Cantwell; Enrico Di Cera
Journal:  Proc Natl Acad Sci U S A       Date:  2003-11-11       Impact factor: 11.205

3.  Redesigning allosteric activation in an enzyme.

Authors:  Sadhna Rana; Nicola Pozzi; Leslie A Pelc; Enrico Di Cera
Journal:  Proc Natl Acad Sci U S A       Date:  2011-02-22       Impact factor: 11.205

4.  Functional mapping of the surface residues of human thrombin.

Authors:  M Tsiang; A K Jain; K E Dunn; M E Rojas; L L Leung; C S Gibbs
Journal:  J Biol Chem       Date:  1995-07-14       Impact factor: 5.157

5.  Evidence that human alpha-thrombin is a monovalent cation-activated enzyme.

Authors:  C L Orthner; D P Kosow
Journal:  Arch Biochem Biophys       Date:  1980-06       Impact factor: 4.013

6.  Rational design of a potent anticoagulant thrombin.

Authors:  A M Cantwell; E Di Cera
Journal:  J Biol Chem       Date:  2000-12-22       Impact factor: 5.157

7.  The thrombin mutant W215A/E217A shows safe and potent anticoagulant and antithrombotic effects in vivo.

Authors:  Andras Gruber; Angelene M Cantwell; Enrico Di Cera; Stephen R Hanson
Journal:  J Biol Chem       Date:  2002-06-17       Impact factor: 5.157

8.  The refined 1.9-A X-ray crystal structure of D-Phe-Pro-Arg chloromethylketone-inhibited human alpha-thrombin: structure analysis, overall structure, electrostatic properties, detailed active-site geometry, and structure-function relationships.

Authors:  W Bode; D Turk; A Karshikov
Journal:  Protein Sci       Date:  1992-04       Impact factor: 6.725

9.  The Na+ binding site of thrombin.

Authors:  E Di Cera; E R Guinto; A Vindigni; Q D Dang; Y M Ayala; M Wuyi; A Tulinsky
Journal:  J Biol Chem       Date:  1995-09-22       Impact factor: 5.157

10.  Thrombin is a Na(+)-activated enzyme.

Authors:  C M Wells; E Di Cera
Journal:  Biochemistry       Date:  1992-12-01       Impact factor: 3.162
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