Literature DB >> 21415361

Prostate cancer susceptibility polymorphism rs2660753 is not associated with invasive ovarian cancer.

Ernest K Amankwah1, Linda E Kelemen, Qinggang Wang, Honglin Song, Georgia Chenevix-Trench, Jonathan Beesley, Penelope M Webb, Celeste L Pearce, Anna H Wu, Malcolm C Pike, Daniel O Stram, Jenny Chang-Claude, Shan Wang-Gohrke, Roberta B Ness, Ellen L Goode, Julie M Cunningham, Brooke L Fridley, Robert A Vierkant, Shelley S Tworoger, Alice S Whittemore, Valerie McGuire, Weiva Sieh, Simon A Gayther, Aleksandra Gentry-Maharaj, Usha Menon, Susan J Ramus, Mary Anne Rossing, Jennifer A Doherty, Marc T Goodman, Michael E Carney, Galina Lurie, Lynne R Wilkens, Susanne Krüger Kjær, Estrid Høgdall, Daniel W Cramer, Kathryn L Terry, Montserrat Garcia-Closas, Hannah Yang, Jolanta Lissowska, Hoda Anton-Culver, Argyrios Ziogas, Joellen M Schildkraut, Andrew Berchuck, Paul D P Pharoah.   

Abstract

BACKGROUND: We previously reported an association between rs2660753, a prostate cancer susceptibility polymorphism, and invasive epithelial ovarian cancer (EOC; OR = 1.2, 95% CI=1.0-1.4, P(trend) = 0.01) that showed a stronger association with the serous histological subtype (OR = 1.3, 95% CI = 1.1-1.5, P(trend) = 0.003).
METHODS: We sought to replicate this association in 12 other studies comprising 4,482 cases and 6,894 controls of white non-Hispanic ancestry in the Ovarian Cancer Association Consortium.
RESULTS: No evidence for an association with all cancers or serous cancers was observed in a combined analysis of data from the replication studies (all: OR = 1.0, 95% CI = 0.9-1.1, P(trend) = 0.61; serous: OR = 1.0, 95% CI = 0.9-1.1, P(trend) = 0.85) or from the combined analysis of discovery and replication studies (all: OR = 1.0, 95% CI = 1.0-1.1, P(trend) = 0.28; serous: OR = 1.1, 95% CI = 1.0-1.2, P(trend) = 0.11). There was no evidence for statistical heterogeneity in ORs across the studies.
CONCLUSIONS: Although rs2660753 is a strong prostate cancer susceptibility polymorphism, the association with another hormonally related cancer, invasive EOC, is not supported by this replication study. IMPACT: Our findings, based on a larger sample size, emphasize the importance of replicating potentially promising genetic risk associations. ©2011 AACR.

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Year:  2011        PMID： 21415361      PMCID： PMC3176661          DOI： 10.1158/1055-9965.EPI-11-0053

Source DB:  PubMed          Journal:  Cancer Epidemiol Biomarkers Prev        ISSN： 1055-9965            Impact factor:   4.254


  8 in total

1.  Risk models for familial ovarian and breast cancer.

Authors:  A C Antoniou; S A Gayther; J F Stratton; B A Ponder; D F Easton
Journal:  Genet Epidemiol       Date:  2000-02       Impact factor: 2.135

Review 2.  Role of genetic polymorphisms and ovarian cancer susceptibility.

Authors:  Peter A Fasching; Simon Gayther; Leigh Pearce; Joellen M Schildkraut; Ellen Goode; Falk Thiel; Georgia Chenevix-Trench; Jenny Chang-Claude; Shan Wang-Gohrke; Susan Ramus; Paul Pharoah; Andrew Berchuck
Journal:  Mol Oncol       Date:  2009-02-04       Impact factor: 6.603

3.  Multiple novel prostate cancer predisposition loci confirmed by an international study: the PRACTICAL Consortium.

Authors:  Zsofia Kote-Jarai; Douglas F Easton; Janet L Stanford; Elaine A Ostrander; Johanna Schleutker; Sue A Ingles; Daniel Schaid; Stephen Thibodeau; Thilo Dörk; David Neal; Jenny Donovan; Freddie Hamdy; Angela Cox; Christiane Maier; Walter Vogel; Michelle Guy; Kenneth Muir; Artitaya Lophatananon; Mary-Anne Kedda; Amanda Spurdle; Suzanne Steginga; Esther M John; Graham Giles; John Hopper; Pierre O Chappuis; Pierre Hutter; William D Foulkes; Nancy Hamel; Claudia A Salinas; Joseph S Koopmeiners; Danielle M Karyadi; Bo Johanneson; Tiina Wahlfors; Teuvo L Tammela; Mariana C Stern; Roman Corral; Shannon K McDonnell; Peter Schürmann; Andreas Meyer; Rainer Kuefer; Daniel A Leongamornlert; Malgorzata Tymrakiewicz; Jo-Fen Liu; Tracy O'Mara; R A Frank Gardiner; Joanne Aitken; Amit D Joshi; Gianluca Severi; Dallas R English; Melissa Southey; Stephen M Edwards; Ali Amin Al Olama; Rosalind A Eeles
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2008-08       Impact factor: 4.254

4.  Characterization of the 3p12.3-pcen region associated with tumor suppression in a novel ovarian cancer cell line model genetically modified by chromosome 3 fragment transfer.

Authors:  Neal A L Cody; Zhen Shen; Jean-Sebastien Ripeau; Diane M Provencher; Anne-Marie Mes-Masson; Mario Chevrette; Patricia N Tonin
Journal:  Mol Carcinog       Date:  2009-12       Impact factor: 4.784

5.  Consortium analysis of 7 candidate SNPs for ovarian cancer.

Authors:  Susan J Ramus; Robert A Vierkant; Sharon E Johnatty; Malcolm C Pike; David J Van Den Berg; Anna H Wu; Celeste Leigh Pearce; Usha Menon; Aleksandra Gentry-Maharaj; Simon A Gayther; Richard A DiCioccio; Valerie McGuire; Alice S Whittemore; Honglin Song; Douglas F Easton; Paul D P Pharoah; Montserrat Garcia-Closas; Stephen Chanock; Jolanta Lissowska; Louise Brinton; Kathryn L Terry; Daniel W Cramer; Shelley S Tworoger; Susan E Hankinson; Andrew Berchuck; Patricia G Moorman; Joellen M Schildkraut; Julie M Cunningham; Mark Liebow; Susanne Krüger Kjaer; Estrid Hogdall; Claus Hogdall; Jan Blaakaer; Roberta B Ness; Kirsten B Moysich; Robert P Edwards; Michael E Carney; Galina Lurie; Marc T Goodman; Shan Wang-Gohrke; Silke Kropp; Jenny Chang-Claude; Penelope M Webb; Xiaoqing Chen; Jonathan Beesley; Georgia Chenevix-Trench; Ellen L Goode
Journal:  Int J Cancer       Date:  2008-07-15       Impact factor: 7.396

6.  Generalizability of associations from prostate cancer genome-wide association studies in multiple populations.

Authors:  Kevin M Waters; Loic Le Marchand; Laurence N Kolonel; Kristine R Monroe; Daniel O Stram; Brian E Henderson; Christopher A Haiman
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2009-03-24       Impact factor: 4.254

7.  Multiple newly identified loci associated with prostate cancer susceptibility.

Authors:  Rosalind A Eeles; Zsofia Kote-Jarai; Graham G Giles; Ali Amin Al Olama; Michelle Guy; Sarah K Jugurnauth; Shani Mulholland; Daniel A Leongamornlert; Stephen M Edwards; Jonathan Morrison; Helen I Field; Melissa C Southey; Gianluca Severi; Jenny L Donovan; Freddie C Hamdy; David P Dearnaley; Kenneth R Muir; Charmaine Smith; Melisa Bagnato; Audrey T Ardern-Jones; Amanda L Hall; Lynne T O'Brien; Beatrice N Gehr-Swain; Rosemary A Wilkinson; Angie Cox; Sarah Lewis; Paul M Brown; Sameer G Jhavar; Malgorzata Tymrakiewicz; Artitaya Lophatananon; Sarah L Bryant; Alan Horwich; Robert A Huddart; Vincent S Khoo; Christopher C Parker; Christopher J Woodhouse; Alan Thompson; Tim Christmas; Chris Ogden; Cyril Fisher; Charles Jamieson; Colin S Cooper; Dallas R English; John L Hopper; David E Neal; Douglas F Easton
Journal:  Nat Genet       Date:  2008-02-10       Impact factor: 38.330

8.  Association study of prostate cancer susceptibility variants with risks of invasive ovarian, breast, and colorectal cancer.

Authors:  Honglin Song; Thibaud Koessler; Shahana Ahmed; Susan J Ramus; Susanne Krüger Kjaer; Richard A Dicioccio; Eva Wozniak; Estrid Hogdall; Alice S Whittemore; Valerie McGuire; Bruce A J Ponder; Clare Turnbull; Sarah Hines; Nazneen Rahman; Rosalind A Eeles; Douglas F Easton; Simon A Gayther; Alison M Dunning; Paul D P Pharoah
Journal:  Cancer Res       Date:  2008-11-01       Impact factor: 12.701
  8 in total

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