Literature DB >> 21415019

Norovirus GII-4 causes a more severe gastroenteritis than other noroviruses in young children.

Leena Huhti1, Evelin D Szakal, Leena Puustinen, Marjo Salminen, Heini Huhtala, Oona Valve, Vesna Blazevic, Timo Vesikari.   

Abstract

Norovirus (NoV) GII-4 has emerged as the predominant NoV genotype in outbreaks of gastroenteritis worldwide. We determined clinical features of NoV GII-4 associated acute gastroenteritis (AGE) in comparison with AGE associated with other NoV types in infants during seasons 2001 and 2002. During the prospective follow-up period, 128 primary infections of AGE due to NoV were identified in 405 infants; of these, GII-4 was found in 40 cases (31%). NoV GII-4 was associated with longer duration of diarrhea and vomiting than other NoV genotypes, suggesting greater virulence of NoV GII-4.

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Year:  2011        PMID： 21415019      PMCID： PMC3080904          DOI： 10.1093/infdis/jir039

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  14 in total

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