Literature DB >> 21412358

Genetically modified pigs for medicine and agriculture.

Randall S Prather1, Miaoda Shen, Yifan Dai.   

Abstract

The ability to genetically modify pigs has enabled scientists to create pigs that are beneficial to humans in ways that were previously unimaginable. Improvements in the methods to make genetic modifications have opened up the possibilities of introducing transgenes, knock-outs and knock-ins with precision. The benefits to medicine include the production of pharmaceuticals, the provision of organs for xenotransplantation into humans, and the development of models of human diseases. The benefits to agriculture include resistance to disease, altering the carcass composition such that it is healthier to consume, improving the pig's resistance to heat stress, and protecting the environment. Additional types of genetic modifications will likely provide animals with characteristics that will benefit humans in currently unimagined ways.

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Year:  2008        PMID: 21412358     DOI: 10.7313/upo9781904761679.011

Source DB:  PubMed          Journal:  Biotechnol Genet Eng Rev        ISSN: 0264-8725


  29 in total

1.  Porcine skin-derived stem cells can serve as donor cells for nuclear transfer.

Authors:  Yanhong Hao; David Wax; Zhisheng Zhong; Clifton Murphy; Jason W Ross; August Rieke; Melissa Samuel; Lee Spate; Paul Dyce; Julang Li; Peter Sutovsky; Randall S Prather
Journal:  Cloning Stem Cells       Date:  2009-03

Review 2.  Genetic modifications of pigs for medicine and agriculture.

Authors:  Jeffrey J Whyte; Randall S Prather
Journal:  Mol Reprod Dev       Date:  2011-06-10       Impact factor: 2.609

3.  Fluorescence imaging preparation methods for tissue scaffolds implanted into a green fluorescent protein porcine model.

Authors:  Sarah E Smith; Richard A White; David A Grant; Sheila A Grant
Journal:  Transgenic Res       Date:  2015-06-25       Impact factor: 2.788

Review 4.  Genome editing and genetic engineering in livestock for advancing agricultural and biomedical applications.

Authors:  Bhanu P Telugu; Ki-Eun Park; Chi-Hun Park
Journal:  Mamm Genome       Date:  2017-07-15       Impact factor: 2.957

5.  Microfluidic single-cell analysis shows that porcine induced pluripotent stem cell-derived endothelial cells improve myocardial function by paracrine activation.

Authors:  Mingxia Gu; Patricia K Nguyen; Andrew S Lee; Dan Xu; Shijun Hu; Jordan R Plews; Leng Han; Bruno C Huber; Won Hee Lee; Yongquan Gong; Patricia E de Almeida; Jennifer Lyons; Fumi Ikeno; Cholawat Pacharinsak; Andrew J Connolly; Sanjiv S Gambhir; Robert C Robbins; Michael T Longaker; Joseph C Wu
Journal:  Circ Res       Date:  2012-07-19       Impact factor: 17.367

Review 6.  Meganucleases Revolutionize the Production of Genetically Engineered Pigs for the Study of Human Diseases.

Authors:  Bethany K Redel; Randall S Prather
Journal:  Toxicol Pathol       Date:  2015-10-28       Impact factor: 1.902

7.  Effects of donor fibroblast cell type and transferred cloned embryo number on the efficiency of pig cloning.

Authors:  Zicong Li; Junsong Shi; Dewu Liu; Rong Zhou; Haiyu Zeng; Xiu Zhou; Ranbiao Mai; Shaofen Zeng; Lvhua Luo; Wanxian Yu; Shouquan Zhang; Zhenfang Wu
Journal:  Cell Reprogram       Date:  2012-12-20       Impact factor: 1.987

8.  Development of a high-yield technique to isolate spermatogonial stem cells from porcine testes.

Authors:  Min Hee Park; Ji Eun Park; Min Seong Kim; Kwon Young Lee; Hye Jin Park; Jung Im Yun; Jung Hoon Choi; Eun song Lee; Seung Tae Lee
Journal:  J Assist Reprod Genet       Date:  2014-06-18       Impact factor: 3.412

9.  Bone marrow mesenchymal stem cells are an attractive donor cell type for production of cloned pigs as well as genetically modified cloned pigs by somatic cell nuclear transfer.

Authors:  Zicong Li; Xiaoyan He; Liwen Chen; Junsong Shi; Rong Zhou; Weihua Xu; Dewu Liu; Zhenfang Wu
Journal:  Cell Reprogram       Date:  2013-09-13       Impact factor: 1.987

10.  Generation of AQP2-Cre transgenic mini-pigs specifically expressing Cre recombinase in kidney collecting duct cells.

Authors:  Weiwei Luo; Zhanjun Li; Yongye Huang; Yang Han; Chaogang Yao; Xinping Duan; Hongsheng Ouyang; Li Li
Journal:  Transgenic Res       Date:  2013-12-05       Impact factor: 2.788

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