Literature DB >> 21406462

Children of depressed mothers 1 year after remission of maternal depression: findings from the STAR*D-Child study.

Priya Wickramaratne1, Marc J Gameroff, Daniel J Pilowsky, Carroll W Hughes, Judy Garber, Erin Malloy, Cheryl King, Gabrielle Cerda, A Bela Sood, Jonathan E Alpert, Madhukar H Trivedi, Maurizio Fava, A John Rush, Stephen Wisniewski, Myrna M Weissman.   

Abstract

OBJECTIVE: Maternal major depressive disorder is an established risk factor for child psychopathology. The authors previously reported that 1 year after initiation of treatment for maternal depression, children of mothers whose depression remitted had significantly improved functioning and psychiatric symptoms. This study extends these findings by examining changes in psychiatric symptoms, behavioral problems, and functioning among children of depressed mothers during the first year after the mothers' remission from depression.
METHOD: Children were assessed at baseline and at 3-month intervals with the Schedule for Affective Disorders and Schizophrenia for School-Age Children-Present and Lifetime Version, the Child Behavior Checklist, and the Children's Global Assessment Scale for 1 year after their mothers' remission or for 2 years if the mothers did not remit. The authors compared children of early remitters (0-3 months; N=36), late remitters (3-12 months; N=28), and nonremitters (N=16).
RESULTS: During the postremission year, children of early-remitting mothers showed significant improvement on all outcomes. Externalizing behavioral problems decreased in children of early- and late-remitting mothers but increased in children of nonremitting mothers. Psychiatric symptoms decreased significantly only in children of mothers who remitted, and functioning improved only in children of early-remitting mothers.
CONCLUSIONS: Remission of mothers' depression, regardless of its timing, appears to be related to decreases in problem behaviors and symptoms in their children over the year after remission. The favorable effect of mothers' remission on children's functioning was observed only in children of early-remitting mothers.

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Year:  2011        PMID: 21406462      PMCID: PMC3423977          DOI: 10.1176/appi.ajp.2010.10010032

Source DB:  PubMed          Journal:  Am J Psychiatry        ISSN: 0002-953X            Impact factor:   18.112


  40 in total

1.  Psychopathology in children of parents with recurrent depression.

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2.  Longitudinal study of diagnoses in children of women with unipolar and bipolar affective disorder.

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Journal:  Arch Gen Psychiatry       Date:  1990-12

Review 3.  Children of depressed parents: an integrative review.

Authors:  G Downey; J C Coyne
Journal:  Psychol Bull       Date:  1990-07       Impact factor: 17.737

4.  Hamilton Depression Rating Scale. Extracted from Regular and Change Versions of the Schedule for Affective Disorders and Schizophrenia.

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Journal:  Arch Gen Psychiatry       Date:  1981-01

5.  First episode of depression in children at low and high familial risk for depression.

Authors:  Douglas E Williamson; Boris Birmaher; David A Axelson; Neal D Ryan; Ronald E Dahl
Journal:  J Am Acad Child Adolesc Psychiatry       Date:  2004-03       Impact factor: 8.829

6.  Treatment of depressed mothers of depressed children: pilot study of feasibility.

Authors:  Helen Verdeli; Tova Ferro; Priya Wickramaratne; Steven Greenwald; Carlos Blanco; Myrna M Weissman
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Journal:  Arch Gen Psychiatry       Date:  1983-11

8.  Children of depressed parents. Increased psychopathology and early onset of major depression.

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9.  Sequenced treatment alternatives to relieve depression (STAR*D): rationale and design.

Authors:  A John Rush; Maurizio Fava; Stephen R Wisniewski; Philip W Lavori; Madhukar H Trivedi; Harold A Sackeim; Michael E Thase; Andrew A Nierenberg; Frederic M Quitkin; T Michael Kashner; David J Kupfer; Jerrold F Rosenbaum; Jonathan Alpert; Jonathan W Stewart; Patrick J McGrath; Melanie M Biggs; Kathy Shores-Wilson; Barry D Lebowitz; Louise Ritz; George Niederehe
Journal:  Control Clin Trials       Date:  2004-02

10.  Translating intergenerational research on depression into clinical practice.

Authors:  Myrna M Weissman; Mark Olfson
Journal:  JAMA       Date:  2009-12-23       Impact factor: 56.272

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2.  Developmental cascade effects of interpersonal psychotherapy for depressed mothers: Longitudinal associations with toddler attachment, temperament, and maternal parenting efficacy.

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4.  Pediatric-based intervention to motivate mothers to seek follow-up for depression screens: The Motivating Our Mothers (MOM) trial.

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5.  The effects on children of depressed mothers' remission and relapse over 9 months.

Authors:  M M Weissman; P Wickramaratne; D J Pilowsky; E Poh; M Hernandez; L A Batten; M F Flament; J W Stewart; P Blier
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7.  Web Intervention for Adolescents Affected by Disaster: Population-Based Randomized Controlled Trial.

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Review 8.  Beyond screening: a review of pediatric primary care models to address maternal depression.

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9.  An experimental test of the fetal programming hypothesis: Can we reduce child ontogenetic vulnerability to psychopathology by decreasing maternal depression?

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Review 10.  Treatment of anxiety and depression in the preschool period.

Authors:  Joan L Luby
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