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Literature DB >> 21402471

Sequential and opposing alterations of 5-HT(1A) receptor function during withdrawal from chronic morphine.

Pierre-Eric Lutz¹, Amynah A Pradhan, Celia Goeldner, Brigitte L Kieffer.

Abstract

Addiction is a brain chronic relapsing disorder associated with emotional distress. The serotonergic system and especially the 5-HT(1A) receptor crucially regulate emotional behaviors both in humans and rodents. Using [(35)S]GTPγS autoradiography in mice, we show that 5-HT(1A) receptor function is enhanced by chronic morphine treatment in the medial prefrontal cortex, and decreased in dorsal raphe nucleus one week later, two regions involved in emotional processing. These molecular adaptations could contribute to the development of emotional disorders experienced by former opiate addicts.

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Year: 2011 PMID： 21402471 PMCID： PMC3149735 DOI： 10.1016/j.euroneuro.2011.02.002

Source DB: PubMed Journal: Eur Neuropsychopharmacol ISSN： 0924-977X Impact factor: 4.600

26 in total

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Journal: Trends Neurosci Date: 2000-10 Impact factor: 13.837

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Authors: A Meneses; J A Terrón
Journal: Behav Brain Res Date: 2001-06 Impact factor: 3.332

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Authors: T Jolas; E J Nestler; G K Aghajanian
Journal: Neuroscience Date: 2000 Impact factor: 3.590

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Journal: Neuroreport Date: 1999-11-08 Impact factor: 1.837

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Journal: Naunyn Schmiedebergs Arch Pharmacol Date: 2002-02-01 Impact factor: 3.000

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Authors: G C Harris; G Aston-Jones
Journal: Neuropsychopharmacology Date: 2001-01 Impact factor: 7.853

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Authors: Alex M Gray
Journal: Eur Neuropsychopharmacol Date: 2002-06 Impact factor: 4.600

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Authors: P Celada; M V Puig; J M Casanovas; G Guillazo; F Artigas
Journal: J Neurosci Date: 2001-12-15 Impact factor: 6.167

10. Impaired emotional-like behavior and serotonergic function during protracted abstinence from chronic morphine.

Authors: Celia Goeldner; Pierre-Eric Lutz; Emmanuel Darcq; Thomas Halter; Daniel Clesse; Abdel-Mouttalib Ouagazzal; Brigitte L Kieffer
Journal: Biol Psychiatry Date: 2010-10-14 Impact factor: 13.382

10 in total

1. A history of chronic morphine exposure during adolescence increases despair-like behaviour and strain-dependently promotes sociability in abstinent adult mice.

Authors: P E Lutz; D Reiss; A M Ouagazzal; B L Kieffer
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Review 2. Revolution in GPCR signalling: opioid receptor heteromers as novel therapeutic targets: IUPHAR review 10.

Authors: Wakako Fujita; Ivone Gomes; Lakshmi A Devi
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3. Dissociation of heroin-induced emotional dysfunction from psychomotor activation and physical dependence among inbred mouse strains.

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Journal: Psychopharmacology (Berl) Date: 2014-12-09 Impact factor: 4.530

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Authors: Pierre-Eric Lutz; Brigitte L Kieffer
Journal: Curr Opin Neurobiol Date: 2013-02-28 Impact factor: 6.627

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Authors: Pierre-Eric Lutz; Brigitte L Kieffer
Journal: Trends Neurosci Date: 2012-12-06 Impact factor: 13.837

6. Distinct mu, delta, and kappa opioid receptor mechanisms underlie low sociability and depressive-like behaviors during heroin abstinence.

Authors: Pierre-Eric Lutz; Gulebru Ayranci; Paul Chu-Sin-Chung; Audrey Matifas; Pascale Koebel; Dominique Filliol; Katia Befort; Abdel-Mouttalib Ouagazzal; Brigitte L Kieffer
Journal: Neuropsychopharmacology Date: 2014-05-30 Impact factor: 7.853

7. Kappa opioid receptor antagonism and chronic antidepressant treatment have beneficial activities on social interactions and grooming deficits during heroin abstinence.

Authors: L Lalanne; G Ayranci; D Filliol; C Gavériaux-Ruff; K Befort; B L Kieffer; P-E Lutz
Journal: Addict Biol Date: 2016-03-22 Impact factor: 4.280