| Literature DB >> 11006462 |
J A Stamford1, C Davidson, D P McLaughlin, S E Hopwood.
Abstract
The serotonergic cells of the dorsal raphé nucleus innervate much of the forebrain and are thought to be involved in the mechanism of action of antidepressants. Dysfunction of these cells might be involved in the neural mechanisms underlying depression and suicide. The traffic in pathways emanating from the dorsal raphé nucleus is controlled by 5-HT(1) autoreceptors. Until recently it was thought that the autoreceptors in the dorsal raphé nucleus were solely of the 5-HT(1A) subtype. In this article, we discuss evidence that the situation is more complex and that multiple 5-HT(1) subtypes govern different aspects of 5-HT function in the dorsal raphé nucleus presenting new therapeutic opportunities.Entities:
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Year: 2000 PMID： 11006462 DOI： 10.1016/s0166-2236(00)01631-3
Source DB: PubMed Journal: Trends Neurosci ISSN： 0166-2236 Impact factor: 13.837